Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sara L. Adamski-Werner"'
Autor:
Nicole B. Servant, Mark E. Williams, Paul F. Brust, Huixian Tang, Melissa S. Wong, Qing Chen, Marketa Lebl-Rinnova, Sara L. Adamski-Werner, Catherine Tachdjian, Guy Servant
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The sweet taste receptor is rather unique, recognizing a diverse repertoire of natural or synthetic ligands, with a surprisingly large structural diversity, and with potencies stretching over more than six orders of magnitude. Yet, it is not clear if
Externí odkaz:
https://doaj.org/article/9d914c5347d74a30adf157b87bbb8adf
Gaucher Disease-Associated Glucocerebrosidases Show Mutation-Dependent Chemical Chaperoning Profiles
Autor:
Jeffery W. Kelly, Klaus-Peter Zimmer, Chi-Huey Wong, Anu R. Sawkar, Wei-Chieh Cheng, Sara L. Adamski-Werner, Ernest Beutler
Publikováno v:
Chemistry & Biology. 12:1235-1244
SummaryGaucher disease is a lysosomal storage disorder caused by deficient glucocerebrosidase activity. We have previously shown that the cellular activity of the most common Gaucher disease-associated glucocerebrosidase variant, N370S, is increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9928f17ab53aeac36b2afed064d532c2
https://doi.org/10.1016/j.chembiol.2005.09.007
https://doi.org/10.1016/j.chembiol.2005.09.007
Publikováno v:
Carbohydrate Research. 339:1255-1262
The first gram-scale syntheses of two hyaluronan disaccharides are described. Construction of the (1 → 4)-linked disaccharide 12 was achieved in 12% overall yield using 2,3-bis-dimethyl acetal protection in combination with chlorosilane-induced car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c915e092800e8623234b17d0c5d0ac8
https://doi.org/10.1016/j.carres.2004.03.005
https://doi.org/10.1016/j.carres.2004.03.005
Publikováno v:
Biochemical and biophysical research communications. 348(3)
The amyloidoses are the extracellular subset of a group of diseases in which in vivo protein misfolding leads to a pathologic gain of function, i.e., aggregation leading to protein deposition, with subsequent tissue damage. Wild-type and mutant trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052c63d0b13dfdc9b04c31aac66f83c4
https://pubmed.ncbi.nlm.nih.gov/16904635
https://pubmed.ncbi.nlm.nih.gov/16904635
Autor:
Yoshiki Sekijima, Steven M. Johnson, R. Luke Wiseman, Nora S. Green, Jeffery W. Kelly, Sara L. Adamski-Werner
Publikováno v:
ChemInform. 37
Small molecule-mediated protein stabilization inside or outside of the cell is a promising strategy to treat protein misfolding/misassembly diseases. Herein we focus on the transthyretin (TTR) amyloidoses and demonstrate that preferential ligand bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5a248f63c2370ea0e128d508822503
https://doi.org/10.1002/chin.200614266
https://doi.org/10.1002/chin.200614266
Autor:
Hans E. Purkey, Kyle P. Chiang, Maria T. A. Dendle, Evan T. Powers, Sara L. Adamski-Werner, Hossein Razavi, Jeffery W. Kelly
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(4)
Ten oxazoles bearing a C(4) carboxyl group were synthesized and evaluated as transthyretin (TTR) amyloid fibril inhibitors. Substituting aryls at the C(2) position of the oxazole ring reveals that a 3,5-dichlorophenyl substituent significantly reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97fbe1e126dc6f114234d6a0b30dea62
https://pubmed.ncbi.nlm.nih.gov/15686915
https://pubmed.ncbi.nlm.nih.gov/15686915
Publikováno v:
Journal of medicinal chemistry. 47(2)
Analogues of diflunisal, an FDA-approved nonsteroidal antiinflammatory drug (NSAID), were synthesized and evaluated as inhibitors of transthyretin (TTR) aggregation, including amyloid fibril formation. High inhibitory activity was observed for 26 of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94c505beba4f661f3926c5dfe822283
https://pubmed.ncbi.nlm.nih.gov/14711308
https://pubmed.ncbi.nlm.nih.gov/14711308
Autor:
Gaelle Poulenat, Jennifer B. Bernard, Sara L. Adamski-Werner, Bryan K. S. Yeung, Peter A. Petillo
Publikováno v:
ChemInform. 32
The conversion of methyl carbamate to the corresponding free amine is described for a series of 2-amino-2-deoxy-d-glucosamine derivatives. Cleavage of methoxycarbonyl moiety with MeSiCl3 and triethylamine in dry THF at 60 °C and subsequent aqueous h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ece8dee9bbd7300ed7f768985288e97
https://doi.org/10.1002/chin.200106165
https://doi.org/10.1002/chin.200106165
Autor:
Jennifer B. Bernard, Peter A. Petillo, Gaelle Poulenat, Bryan K. S. Yeung, Sara L. Adamski-Werner
Publikováno v:
Organic letters. 2(20)
The conversion of methyl carbamate to the corresponding free amine is described for a series of 2-amino-2-deoxy-D-glucosamine derivatives. Cleavage of methoxycarbonyl moiety with MeSiCl(3) and triethylamine in dry THF at 60 degrees C and subsequent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b872607a81e21797e36cef5b122a14d4
https://pubmed.ncbi.nlm.nih.gov/11009364
https://pubmed.ncbi.nlm.nih.gov/11009364