Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits.

Autor: Craig A Glastonbury, Sara L Pulit, Julius Honecker, Jenny C Censin, Samantha Laber, Hanieh Yaghootkar, Nilufer Rahmioglu, Emilie Pastel, Katerina Kos, Andrew Pitt, Michelle Hudson, Christoffer Nellåker, Nicola L Beer, Hans Hauner, Christian M Becker, Krina T Zondervan, Timothy M Frayling, Melina Claussnitzer, Cecilia M Lindgren

Publikováno v: PLoS Computational Biology, Vol 16, Iss 8, p e1008044 (2020)

Genetic studies have recently highlighted the importance of fat distribution, as well as overall adiposity, in the pathogenesis of obesity-associated diseases. Using a large study (n = 1,288) from 4 independent cohorts, we aimed to investigate the re

Externí odkaz: https://doaj.org/article/ece9574c1c2a4be88137af51b58a2170

Evidence of survival bias in the association between APOE-Є4 and age at ischemic stroke onset

Autor: Joanna von Berg, Patrick F. McArdle, Paavo Häppölä, Jeffrey Haessler, Charles Kooperberg, Robin Lemmens, Alessandro Pezzini, Vincent Thijs, Sara L. Pulit, Steven J. Kittner, Braxton D. Mitchell, Jeroen de Ridder, Sander W. van der Laan

Publikováno v: Frontiers in Genetics, Vol 15 (2024)

IntroductionLarge genome-wide association studies (GWASs) using case–control study designs have now identified tens of loci associated with ischemic stroke (IS). As a complement to these studies, we performed GWAS in a case-only design to identify

Externí odkaz: https://doaj.org/article/5fe79556aa9743429be4d3f8a5445d26

Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency.

Autor: Adam Kiezun, Sara L Pulit, Laurent C Francioli, Freerk van Dijk, Morris Swertz, Dorret I Boomsma, Cornelia M van Duijn, P Eline Slagboom, G J B van Ommen, Cisca Wijmenga, Genome of the Netherlands Consortium, Paul I W de Bakker, Shamil R Sunyaev

Publikováno v: PLoS Genetics, Vol 9, Iss 2, p e1003301 (2013)

Large-scale population sequencing studies provide a complete picture of human genetic variation within the studied populations. A key challenge is to identify, among the myriad alleles, those variants that have an effect on molecular function, phenot

Externí odkaz: https://doaj.org/article/8d99e27d7b2b479aa5787a4f6862e289

MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix compositionResearch in context

Autor: Catriona Hilton, Matt J. Neville, Laura B.L. Wittemans, Marijana Todorcevic, Katherine E. Pinnick, Sara L. Pulit, Jian'an Luan, Agné Kulyté, Ingrid Dahlman, Nicholas J. Wareham, Luca A. Lotta, Peter Arner, Cecilia M. Lindgren, Claudia Langenberg, Fredrik Karpe

Publikováno v: EBioMedicine, Vol 44, Iss , Pp 467-475 (2019)

Background: Abdominal fat mass is associated with metabolic risk whilst gluteal femoral fat is paradoxically protective. MicroRNAs are known to be necessary for adipose tissue formation and function but their role in regulating human fat distribution

Externí odkaz: https://doaj.org/article/132352bcea1b412e8fe99d6280bbbd8f

Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations

Autor: Gerard Temprano‐Sagrera, Colleen M. Sitlani, William P. Bone, Miguel Martin‐Bornez, Benjamin F. Voight, Alanna C. Morrison, Scott M. Damrauer, Paul S. de Vries, Nicholas L. Smith, Maria Sabater‐Lleal, Abbas Dehghan, Adam S Heath, Alanna C Morrison, Alex P Reiner, Andrew Johnson, Anne Richmond, Annette Peters, Astrid van Hylckama Vlieg, Barbara McKnight, Bruce M Psaty, Caroline Hayward, Cavin Ward‐Caviness, Christopher O’Donnell, Daniel Chasman, David P Strachan, David A Tregouet, Dennis Mook‐Kanamori, Dipender Gill, Florian Thibord, Folkert W Asselbergs, Frank W.G. Leebeek, Frits R Rosendaal, Gail Davies, Georg Homuth, Gerard Temprano, Harry Campbell, Herman A Taylor, Jan Bressler, Jennifer E Huffman, Jerome I Rotter, Jie Yao, James F Wilson, Joshua C Bis, Julie M Hahn, Karl C Desch, Kerri L Wiggins, Laura M Raffield, Lawrence F Bielak, Lisa R Yanek, Marcus E Kleber, Martina Mueller, Maryam Kavousi, Massimo Mangino, Melissa Liu, Michael R Brown, Matthew P Conomos, Min‐A Jhun, Ming‐Huei Chen, Moniek P.M. de Maat, Nathan Pankratz, Nicholas L Smith, Patricia A Peyser, Paul Elliot, Paul S de Vries, Peng Wei, Philipp S Wild, Pierre E Morange, Pim van der Harst, Qiong Yang, Ngoc‐Quynh Le, Riccardo Marioni, Ruifang Li, Scott M Damrauer, Simon R Cox, Stella Trompet, Stephan B Felix, Uwe Völker, Weihong Tang, Wolfgang Koenig, J. Wouter Jukema, Xiuqing Guo, Sara Lindstrom, Lu Wang, Erin N Smith, William Gordon, Mariza de Andrade, Jennifer A Brody, Jack W Pattee, Jeffrey Haessler, Ben M Brumpton, Daniel I Chasman, Pierre Suchon, Constance Turman, Marine Germain, James MacDonald, Sigrid K Braekkan, Sebastian M Armasu, Rabecca D Jackson, Jonas B Nielsen, Franco Giulianini, Marja K Puurunen, Manal Ibrahim, Susan R Heckbert, Theo K Bammler, Kelly A Frazer, Bryan M McCauley, Kent Taylor, James S Pankow, Alexander P Reiner, Maiken E Gabrielsen, Jean‐François Deleuze, Chris J O’Donnell, Jihye Kim, Peter Kraft, John‐Bjarne Hansen, John A Heit, Charles Kooperberg, Kristian Hveem, Paul M Ridker, Pierre‐Emmanuel Morange, Andrew D Johnson, Christopher Kabrhel, David‐Alexandre Trégouët, Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten‐Jacobs, Anne‐Katrin Giese, Sander W van der Laan, Solveig Gretarsdottir, Christopher D Anderson, Michael Chong, Hieab HH Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M Bartz, Oscar R Benavente, Steve Bevan, Giorgio B Boncoraglio, Robert D Brown, Adam S Butterworth, Caty Carrera, Cara L Carty, Wei‐Min Chen, John W Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul IW de Bakker, Anita L DeStefano, Marcel den Hoed, Qing Duan, Stefan T Engelter, Guido J Falcone, Rebecca F Gottesman, Raji P Grewal, Vilmundur Gudnason, Stefan Gustafsson, Tamara B Harris, Ahamad Hassan, Aki S Havulinna, Elizabeth G Holliday, George Howard, Fang‐Chi Hsu, Hyacinth I Hyacinth, M Arfan Ikram, Erik Ingelsson, Marguerite R Irvin, Xueqiu Jian, Jordi Jiménez‐Conde, Julie A Johnson, J Wouter Jukema, Masahiro Kanai, Keith L Keene, Brett M Kissela, Dawn O Kleindorfer, Michiaki Kubo, Leslie A Lange, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Jin‐Moo Lee, Robin Lemmens, Didier Leys, Cathryn M Lewis, Wei‐Yu Lin, Arne G Lindgren, Erik Lorentzen, Patrik K Magnusson, Jane Maguire, Ani Manichaikul, Patrick F McArdle, James F Meschia, Braxton D Mitchell, Thomas H Mosley, Michael A Nalls, Toshiharu Ninomiya, Martin J O’Donnell, Sara L Pulit, Kristiina Rannikmäe, Kathryn M Rexrode, Kenneth Rice, Stephen S Rich, Natalia S Rost, Peter M Rothwell, Tatjana Rundek, Ralph L Sacco, Saori Sakaue, Michele M Sale, Veikko Salomaa, Bishwa R Sapkota, Reinhold Schmidt, Carsten O Schmidt, Ulf Schminke, Pankaj Sharma, Agnieszka Slowik, Cathie LM Sudlow, Christian Tanislav, Turgut Tatlisumak, Kent D Taylor, Vincent NS Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Christophe Tzourio, Cornelia M van Duijn, Matthew Walters, Nicholas J Wareham, Sylvia Wassertheil‐Smoller, James G Wilson, Salim Yusuf, Najaf Amin, Hugo S Aparicio, Donna K Arnett, John Attia, Alexa S Beiser, Claudine Berr, Julie E Buring, Mariana Bustamante, Valeria Caso, Yu‐Ching Cheng, Seung Hoan Choi, Ayesha Chowhan, Natalia Cullell, Jean‐François Dartigues, Hossein Delavaran, Pilar Delgado, Marcus Dörr, Gunnar Engström, Ian Ford, Wander S Gurpreet, Anders Hamsten, Laura Heitsch, Atsushi Hozawa, Laura Ibanez, Andreea Ilinca, Martin Ingelsson, Motoki Iwasaki, Rebecca D Jackson, Katarina Jood, Pekka Jousilahti, Sara Kaffashian, Lalit Kalra, Masahiro Kamouchi, Takanari Kitazono, Olafur Kjartansson, Manja Kloss, Peter J Koudstaal, Jerzy Krupinski, Daniel L Labovitz, Cathy C Laurie, Christopher R Levi, Linxin Li, Lars Lind, Cecilia M Lindgren, Vasileios Lioutas, Yong Mei Liu, Oscar L Lopez, Hirata Makoto, Nicolas Martinez‐Majander, Koichi Matsuda, Naoko Minegishi, Joan Montaner, Andrew P Morris, Elena Muiño, Martina Müller‐Nurasyid, Bo Norrving, Soichi Ogishima, Eugenio A Parati, Leema Reddy Peddareddygari, Nancy L Pedersen, Joanna Pera, Markus Perola, Alessandro Pezzini, Silvana Pileggi, Raquel Rabionet, Iolanda Riba‐Llena, Marta Ribasés, Jose R Romero, Jaume Roquer, Anthony G Rudd, Antti‐Pekka Sarin, Ralhan Sarju, Chloe Sarnowski, Makoto Sasaki, Claudia L Satizabal, Mamoru Satoh, Naveed Sattar, Norie Sawada, Gerli Sibolt, Ásgeir Sigurdsson, Albert Smith, Kenji Sobue, Carolina Soriano‐Tárraga, Tara Stanne, O Colin Stine, David J Stott, Konstantin Strauch, Takako Takai, Hideo Tanaka, Kozo Tanno, Alexander Teumer, Liisa Tomppo, Nuria P Torres‐Aguila, Emmanuel Touze, Shoichiro Tsugane, Andre G Uitterlinden, Einar M Valdimarsson, Sven J van der Lee, Henry Völzke, Kenji Wakai, David Weir, Stephen R Williams, Charles DA Wolfe, Quenna Wong, Huichun Xu, Taiki Yamaji, Dharambir K Sanghera, Olle Melander, Christina Jern, Daniel Strbian, Israel Fernandez‐Cadenas, W T Longstreth, Arndt Rolfs, Jun Hata, Daniel Woo, Jonathan Rosand, Guillaume Pare, Jemma C Hopewell, Danish Saleheen, Kari Stefansson, Bradford B Worrall, Steven J Kittner, Sudha Seshadri, Myriam Fornage, Hugh S Markus, Joanna MM Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans

Publikováno v: Temprano-Sagrera, G, Sitlani, C M, Bone, W P, Martin-Bornez, M, Voight, B F, Morrison, A C, Damrauer, S M, de Vries, P S, Smith, N L, Sabater-Lleal, M, Dehghan, A, Heath, A S, Morrison, A C, Reiner, A P, Johnson, A, Richmond, A, Peters, A, van Hylckama Vlieg, A, McKnight, B, Psaty, B M, Hayward, C, Ward-Caviness, C, O’Donnell, C, Chasman, D I, Strachan, D P, Trégouët, D A, Mook-Kanamori, D, Gill, D, Thibord, F, Asselbergs, F W, Leebeek, F W G, Rosendaal, F R, Davies, G, Homuth, G, Temprano, G, Campbell, H, Taylor, H A, Bressler, J, Huffman, J E, Rotter, J I, Yao, J, Wilson, J F, Bis, J C, Hahn, J M, Desch, K C, Wiggins, K L, Raffield, L M, Bielak, L F, Yanek, L R, Kleber, M E, Sabater-Lleal, M, Mueller, M, Kavousi, M, Mangino, M, Liu, M, Brown, M R, Conomos, M P, Jhun, M A, Chen, M H, de Maat, M P M, Pankratz, N, Smith, N L, Peyser, P A, Elliot, P, de Vries, P S, Wei, P, Wild, P S, Morange, P E, van der Harst, P, Yang, Q, Le, N Q, Marioni, R, Li, R, Damrauer, S M, Cox, S R, Trompet, S, Felix, S B, Völker, U, Tang, W, Koenig, W, Jukema, J W, Guo, X, Lindstrom, S, Wang, L, Smith, E N, Gordon, W, van Hylckama Vlieg, A, de Andrade, M, Brody, J A, Pattee, J W, Haessler, J, Brumpton, B M, Chasman, D I, Suchon, P, Chen, M H, Turman, C, Germain, M, Wiggins, K L, MacDonald, J, Braekkan, S K, Armasu, S M, Pankratz, N, Jackson, R D, Nielsen, J B, Giulianini, F, Puurunen, M K, Ibrahim, M, Heckbert, S R, Bammler, T K, Frazer, K A, McCauley, B M, Taylor, K D, Pankow, J S, Reiner, A P, Gabrielsen, M E, Deleuze, J F, O’Donnell, C J, Kim, J, McKnight, B, Kraft, P, Hansen, J B, Rosendaal, F R, Heit, J A, Psaty, B M, Tang, W, Kooperberg, C, Hveem, K, Ridker, P M, Morange, P E, Johnson, A, Kabrhel, C, Trégouët, D A, Smith, N L, Malik, R, Chauhan, G, Traylor, M, Sargurupremraj, M, Okada, Y, Mishra, A, Rutten-Jacobs, L, Giese, A K, van der Laan, S W, Gretarsdottir, S, Anderson, C D, Chong, M, Adams, H H H, Ago, T, Almgren, P, Amouyel, P, Ay, H, Bartz, T M, Benavente, O R, Bevan, S, Boncoraglio, G B, Brown, R D, Butterworth, A S, Carrera, C, Carty, C L, Chasman, D I, Chen, W M, Cole, J W, Correa, A, Cotlarciuc, I, Cruchaga, C, Danesh, J, de Bakker, P I W, DeStefano, A L, den Hoed, M, Duan, Q, Engelter, S T, Falcone, G J, Gottesman, R F, Grewal, R P, Gudnason, V, Gustafsson, S, Haessler, J, Harris, T B, Hassan, A, Havulinna, A S, Heckbert, S R, Holliday, E G, Howard, G, Hsu, F C, Hyacinth, H I, Arfan Ikram, M, Ingelsson, E, Irvin, M R, Jian, X, Jiménez-Conde, J, Johnson, J A, Jukema, J W, Kanai, M, Keene, K L, Kissela, B M, Kleindorfer, D O, Kooperberg, C, Kubo, M, Lange, L A, Langefeld, C D, Langenberg, C, Launer, L J, Lee, J M, Lemmens, R, Leys, D, Lewis, C M, Lin, W Y, Lindgren, A G, Lorentzen, E, Magnusson, P K, Maguire, J, Manichaikul, A, McArdle, P F, Meschia, J F, Mitchell, B D, Mosley, T H, Nalls, M A, Ninomiya, T, O’Donnell, M J, Psaty, B M, Pulit, S L, Rannikmäe, K, Reiner, A P, Rexrode, K M, Rice, K, Rich, S S, Ridker, P M, Rost, N S, Rothwell, P M, Rotter, J I, Rundek, T, Sacco, R L, Sakaue, S, Sale, M M, Salomaa, V, Sapkota, B R, Schmidt, R, Schmidt, C O, Schminke, U, Sharma, P, Slowik, A, Sudlow, C L M, Tanislav, C, Tatlisumak, T, Taylor, K D, Thijs, V N S, Thorleifsson, G, Thorsteinsdottir, U, Tiedt, S, Trompet, S, Tzourio, C, van Duijn, C M, Walters, M, Wareham, N J, Wassertheil-Smoller, S, Wilson, J F, Wiggins, K L, Yang, Q, Yusuf, S, Amin, N, Aparicio, H S, Arnett, D K, Attia, J, Beiser, A S, Berr, C, Buring, J E, Bustamante, M, Caso, V, Cheng, Y C, Hoan Choi, S, Chowhan, A, Cullell, N, Dartigues, J F, Delavaran, H, Delgado, P, Dörr, M, Engström, G, Ford, I, Gurpreet, W S, Hamsten, A, Heitsch, L, Hozawa, A, Ibanez, L, Ilinca, A, Ingelsson, M, Iwasaki, M, Jackson, R D, Jood, K, Jousilahti, P, Kaffashian, S, Kalra, L, Kamouchi, M, Kitazono, T, Kjartansson, O, Kloss, M, Koudstaal, P J, Krupinski, J, Labovitz, D L, Laurie, C C, Levi, C R, Li, L, Lind, L, Lindgren, C M, Lioutas, V, Mei Liu, Y, Lopez, O L, Makoto, H, Martinez-Majander, N, Matsuda, K, Minegishi, N, Montaner, J, Morris, A P, Muiño, E, Müller-Nurasyid, M, Norrving, B, Ogishima, S, Parati, E A, Reddy Peddareddygari, L, Pedersen, N L, Pera, J, Perola, M, Pezzini, A, Pileggi, S, Rabionet, R, Riba-Llena, I, Ribasés, M, Romero, J R, Roquer, J, Rudd, A G, Sarin, A P, Sarju, R, Sarnowski, C, Sasaki, M, Satizabal, C L, Satoh, M, Sattar, N, Sawada, N, Sibolt, G, Sigurdsson, Á, Smith, A, Sobue, K, Soriano-Tárraga, C, Stanne, T, Colin Stine, O, Stott, D J, Strauch, K, Takai, T, Tanaka, H, Tanno, K, Teumer, A, Tomppo, L, Torres-Aguila, N P, Touze, E, Tsugane, S, Uitterlinden, A G, Valdimarsson, E M, van der Lee, S J, Völzke, H, Wakai, K, Weir, D, Williams, S R, Wolfe, C D A, Wong, Q, Xu, H, Yamaji, T, Sanghera, D K, Melander, O, Jern, C, Strbian, D, Fernandez-Cadenas, I, Longstreth, W T, Rolfs, A, Hata, J, Woo, D, Rosand, J, Pare, G, Hopewell, J C, Saleheen, D, Stefansson, K, Worrall, B B, Kittner, S J, Seshadri, S, Fornage, M, Markus, H S, Howson, J M M, Kamatani, Y, Debette, S & Dichgans, M 2022, ' Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations ', Journal of Thrombosis and Haemostasis, vol. 20, no. 6, pp. 1331-1349 . https://doi.org/10.1111/jth.15698
Temprano-Sagrera, G, Sitlani, C M, Bone, W P, Martin-Bornez, M, Voight, B F, Morrison, A C, Damrauer, S M, de Vries, P S, Smith, N L, Sabater-Lleal, M, Dehghan, A, Heath, A S, Morrison, A C, Reiner, A P, Johnson, A, Richmond, A, Peters, A, van Hylckama Vlieg, A, McKnight, B, Psaty, B M, Hayward, C, Ward-Caviness, C, O’Donnell, C, Chasman, D, Strachan, D P, Tregouet, D A, Mook-Kanamori, D, Gill, D, Thibord, F, Asselbergs, F W, Leebeek, F W G, Rosendaal, F R, Davies, G, Homuth, G, Temprano, G, Campbell, H, Taylor, H A, Bressler, J, Huffman, J E, Rotter, J I, Yao, J, Wilson, J F, Bis, J C, Hahn, J M, Desch, K C, Wiggins, K L, Raffield, L M, Bielak, L F, Yanek, L R, Kleber, M E, Sabater-Lleal, M, Mueller, M, Kavousi, M, Mangino, M, Liu, M, Brown, M R, Conomos, M P, Jhun, M-A, Chen, M-H, de Maat, M P M, Pankratz, N, Smith, N L, Peyser, P A, Elliot, P, de Vries, P S, Wei, P, Wild, P S, Morange, P E, van der Harst, P, Yang, Q, le, N-Q, Marioni, R, Li, R, Damrauer, S M, Cox, S R, Trompet, S, Felix, S B, Völker, U, Tang, W, Koenig, W, Jukema, J W, Guo, X, Lindstrom, S, Wang, L, Smith, E N, Gordon, W, van Hylckama Vlieg, A, de Andrade, M, Brody, J A, Pattee, J W, Haessler, J, Brumpton, B M, Chasman, D I, Suchon, P, Chen, M-H, Turman, C, Germain, M, Wiggins, K L, MacDonald, J, Braekkan, S K, Armasu, S M, Pankratz, N, Jackson, R D, Nielsen, J B, Giulianini, F, Puurunen, M K, Ibrahim, M, Heckbert, S R, Bammler, T K, Frazer, K A, McCauley, B M, Taylor, K, Pankow, J S, Reiner, A P, Gabrielsen, M E, Deleuze, J-F, O’Donnell, C J, Kim, J, McKnight, B, Kraft, P, Hansen, J-B, Rosendaal, F R, Heit, J A, Psaty, B M, Tang, W, Kooperberg, C, Hveem, K, Ridker, P M, Morange, P-E, Johnson, A D, Kabrhel, C, Trégouët, D-A, Smith, N L, Malik, R, Chauhan, G, Traylor, M, Sargurupremraj, M, Okada, Y, Mishra, A, Rutten-Jacobs, L, Giese, A-K, van der Laan, S W, Gretarsdottir, S, Anderson, C D, Chong, M, Adams, H H H, Ago, T, Almgren, P, Amouyel, P, Ay, H, Bartz, T M, Benavente, O R, Bevan, S, Boncoraglio, G B, Brown, R D, Butterworth, A S, Carrera, C, Carty, C L, Chasman, D I, Chen, W-M, Cole, J W, Correa, A, Cotlarciuc, I, Cruchaga, C, Danesh, J, de Bakker, P I W, DeStefano, A L, den Hoed, M, Duan, Q, Engelter, S T, Falcone, G J, Gottesman, R F, Grewal, R P, Gudnason, V, Gustafsson, S, Haessler, J, Harris, T B, Hassan, A, Havulinna, A S, Heckbert, S R, Holliday, E G, Howard, G, Hsu, F-C, Hyacinth, H I, Arfan Ikram, M, Ingelsson, E, Irvin, M R, Jian, X, Jiménez-Conde, J, Johnson, J A, Jukema, J W, Kanai, M, Keene, K L, Kissela, B M, Kleindorfer, D O, Kooperberg, C, Kubo, M, Lange, L A, Langefeld, C D, Langenberg, C, Launer, L J, Lee, J-M, Lemmens, R, Leys, D, Lewis, C M, Lin, W-Y, Lindgren, A G, Lorentzen, E, Magnusson, P K, Maguire, J, Manichaikul, A, McArdle, P F, Meschia, J F, Mitchell, B D, Mosley, T H, Nalls, M A, Ninomiya, T, O’Donnell, M J, Psaty, B M, Pulit, S L, Rannikmäe, K, Reiner, A P, Rexrode, K M, Rice, K, Rich, S S, Ridker, P M, Rost, N S, Rothwell, P M, Rotter, J I, Rundek, T, Sacco, R L, Sakaue, S, Sale, M M, Salomaa, V, Sapkota, B R, Schmidt, R, Schmidt, C O, Schminke, U, Sharma, P, Slowik, A, Sudlow, C L M, Tanislav, C, Tatlisumak, T, Taylor, K D, Thijs, V N S, Thorleifsson, G, Thorsteinsdottir, U, Tiedt, S, Trompet, S, Tzourio, C, van Duijn, C M, Walters, M, Wareham, N J, Wassertheil-Smoller, S, Wilson, J G, Wiggins, K L, Yang, Q, Yusuf, S, Amin, N, Aparicio, H S, Arnett, D K, Attia, J, Beiser, A S, Berr, C, Buring, J E, Bustamante, M, Caso, V, Cheng, Y-C, Hoan Choi, S, Chowhan, A, Cullell, N, Dartigues, J-F, Delavaran, H, Delgado, P, Dörr, M, Engström, G, Ford, I, Gurpreet, W S, Hamsten, A, Heitsch, L, Hozawa, A, Ibanez, L, Ilinca, A, Ingelsson, M, Iwasaki, M, Jackson, R D, Jood, K, Jousilahti, P, Kaffashian, S, Kalra, L, Kamouchi, M, Kitazono, T, Kjartansson, O, Kloss, M, Koudstaal, P J, Krupinski, J, Labovitz, D L, Laurie, C C, Levi, C R, Li, L, Lind, L, Lindgren, C M, Lioutas, V, Mei Liu, Y, Lopez, O L, Makoto, H, Martinez-Majander, N, Matsuda, K, Minegishi, N, Montaner, J, Morris, A P, Muiño, E, Müller-Nurasyid, M, Norrving, B, Ogishima, S, Parati, E A, Reddy Peddareddygari, L, Pedersen, N L, Pera, J, Perola, M, Pezzini, A, Pileggi, S, Rabionet, R, Riba-Llena, I, Ribasés, M, Romero, J R, Roquer, J, Rudd, A G, Sarin, A-P, Sarju, R, Sarnowski, C, Sasaki, M, Satizabal, C L, Satoh, M, Sattar, N, Sawada, N, Sibolt, G, Sigurdsson, Á, Smith, A, Sobue, K, Soriano-Tárraga, C, Stanne, T, Colin Stine, O, Stott, D J, Strauch, K, Takai, T, Tanaka, H, Tanno, K, Teumer, A, Tomppo, L, Torres-Aguila, N P, Touze, E, Tsugane, S, Uitterlinden, A G, Valdimarsson, E M, van der Lee, S J, Völzke, H, Wakai, K, Weir, D, Williams, S R, Wolfe, C D A, Wong, Q, Xu, H, Yamaji, T, Sanghera, D K, Melander, O, Jern, C, Strbian, D, Fernandez-Cadenas, I, Longstreth, W T, Rolfs, A, Hata, J, Woo, D, Rosand, J, Pare, G, Hopewell, J C, Saleheen, D, Stefansson, K, Worrall, B B, Kittner, S J, Seshadri, S, Fornage, M, Markus, H S, Howson, J M M, Kamatani, Y, Debette, S & Dichgans, M 2022, ' Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations ', Journal of Thrombosis and Haemostasis, vol. 20, no. 6, pp. 1331-1349 . https://doi.org/10.1111/jth.15698
Journal of Thrombosis and Haemostasis, 20(6), 1331-1349. Wiley-Blackwell

Background: Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b7442423f44fe602d89a89feee11d1
https://hdl.handle.net/20.500.11820/264ae571-0038-4372-9a30-c81b5c9f6905