Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sara L, Zimmer"'
Autor:
Amanda T. S. Albanaz, Mark Carrington, Alexander O. Frolov, Anna I. Ganyukova, Evgeny S. Gerasimov, Alexei Y. Kostygov, Julius Lukeš, Marina N. Malysheva, Jan Votýpka, Alexandra Zakharova, Kristína Záhonová, Sara L. Zimmer, Vyacheslav Yurchenko, Anzhelika Butenko
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background Protists of the family Trypanosomatidae (phylum Euglenozoa) have gained notoriety as parasites affecting humans, domestic animals, and agricultural plants. However, the true extent of the group's diversity spreads far beyond the m
Externí odkaz:
https://doaj.org/article/1ccbe175e908488286a6ce1d72afa3ae
Autor:
Clara M. Smoniewski, Poorya Mirzavand Borujeni, Austin Petersen, Marshall Hampton, Reza Salavati, Sara L. Zimmer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Since the first identification of circular RNA (circRNA) in viral-like systems, reports of circRNAs and their functions in various organisms, cell types, and organelles have greatly expanded. Here, we report the first evidence, to our knowle
Externí odkaz:
https://doaj.org/article/5499c1d696994ab49e5382be8a098c76
Autor:
Clara M. Smoniewski, Poorya Mirzavand Borujeni, Marshall Hampton, Austin Petersen, Sean P. Faacks, Reza Salavati, Sara L. Zimmer
Publikováno v:
Frontiers in Parasitology, Vol 2 (2024)
RNA-specific nucleotidyltransferases (rNTrs) add nontemplated nucleotides to the 3′ end of RNA. Two noncanonical rNTRs that are thought to be poly(A) polymerases (PAPs) have been identified in the mitochondria of trypanosomes – KPAP1 and KPAP2. K
Externí odkaz:
https://doaj.org/article/ca87d01f0a284f7d9e9bef107d3fec72
Autor:
Evgeny S. Gerasimov, Dmitry A. Afonin, Oksana A. Korzhavina, Julius Lukeš, Ross Low, Neil Hall, Kevin Tyler, Vyacheslav Yurchenko, Sara L. Zimmer
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6388-6402 (2022)
The kinetoplastids are unicellular flagellates that derive their name from the ‘kinetoplast’, a region within their single mitochondrion harboring its organellar genome of high DNA content, called kinetoplast (k) DNA. Some protein products of thi
Externí odkaz:
https://doaj.org/article/35843f66a2304dfebdbeec2e4b218281
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 8, Iss 8, p 384 (2023)
Instability is an intriguing characteristic of many protist genomes, and trypanosomatids are not an exception in this respect. Some regions of trypanosomatid genomes evolve fast. For instance, the trypanosomatid mitochondrial (kinetoplast) genome con
Externí odkaz:
https://doaj.org/article/e30119c1956249378cfda35dc4de8c18
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0244858 (2021)
In this study, hierarchies of probabilistic models are evaluated for their ability to characterize the untemplated addition of adenine and uracil to the 3' ends of mitochondrial mRNAs of the human pathogen Trypanosoma brucei, and for their generative
Externí odkaz:
https://doaj.org/article/e18d4c6a47c04bf1b14ec8b922d9dcad
Autor:
Clara M. Smoniewski, Poorya Mirzavand Borujeni, Austin Petersen, Marshall Hampton, Reza Salavati, Sara L. Zimmer
Publikováno v:
bioRxiv
Since the first identification of circular RNA (circRNA) in viral-like systems, reports of circRNAs and their functions in various organisms, cell types, and organelles have greatly expanded. Here, we report the first evidence of circular mRNA in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e545979110a6034eebc47e88d0fd2e
https://doi.org/10.1101/2023.02.10.528059
https://doi.org/10.1101/2023.02.10.528059
Autor:
Amanda Termuhlen, Jerica M. Berge, Jakub Tolar, Sophie Watson, Heather Dorr, Snigdha Pusalavidyasagar, Kait C. Macheledt, Alicia Kunin-Batson, Rebekah Pratt, Sara L Zimmer
Publikováno v:
Academic Medicine. 97:370-377
Many medical schools are instituting gender equity initiatives to address long-standing inequities (e.g., salary, leadership positions, resource distribution) between women and men in academic medicine. However, few theory-driven models exist with bu
Autor:
Fred R. Opperdoes, Anzhelika Butenko, Alexandra Zakharova, Evgeny S. Gerasimov, Sara L. Zimmer, Julius Lukeš, Vyacheslav Yurchenko
Publikováno v:
Pathogens, Vol 10, Iss 1, p 68 (2021)
A recently redescribed two-flagellar trypanosomatid Vickermania ingenoplastis is insensitive to the classical inhibitors of respiration and thrives under anaerobic conditions. Using genomic and transcriptomic data, we analyzed its genes of the core m
Externí odkaz:
https://doaj.org/article/4bca302a9216402a822e53cc2fee15e9
Publikováno v:
Pathogens, Vol 9, Iss 4, p 281 (2020)
In kinetoplastids, the first seven steps of glycolysis are compartmentalized into a glycosome along with parts of other metabolic pathways. This organelle shares a common ancestor with the better-understood eukaryotic peroxisome. Much of our understa
Externí odkaz:
https://doaj.org/article/8319f073c5e34347ba9f96b189c1207d