Výsledky vyhledávání - "Sara Keyhani"

Akademický článek

Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation

Autor: Hannah Steinert, Florian Sochor, Anna Wacker, Janina Buck, Christina Helmling, Fabian Hiller, Sara Keyhani, Jonas Noeske, Steffen Grimm, Martin M Rudolph, Heiko Keller, Rachel Anne Mooney, Robert Landick, Beatrix Suess, Boris Fürtig, Jens Wöhnert, Harald Schwalbe

Publikováno v: eLife, Vol 6 (2017)

In bacteria, the regulation of gene expression by cis-acting transcriptional riboswitches located in the 5'-untranslated regions of messenger RNA requires the temporal synchronization of RNA synthesis and ligand binding-dependent conformational refol

Externí odkaz: https://doaj.org/article/9ca65ffa9a5e4f31902497f97157d4fa

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More than Proton Detection-New Avenues for NMR Spectroscopy of RNA

Autor: Harald Schwalbe, Sara Keyhani, Boris Fürtig, Robbin Schnieders

Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)

Ribonucleic acid oligonucleotides (RNAs) play pivotal roles in cellular function (riboswitches), chemical biology applications (SELEX‐derived aptamers), cell biology and biomedical applications (transcriptomics). Furthermore, a growing number of RN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10173ad729fee1c72076fd6f68bb64c7
https://pubmed.ncbi.nlm.nih.gov/31454110

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Direct 13C-detected NMR experiments for mapping and characterization of hydrogen bonds in RNA

Autor: Robbin Schnieders, Heidi Zetzsche, Sara Keyhani, Christina Helmling, Boris Fürtig, Christian Richter, Helena Kovacs, Harald Schwalbe

Publikováno v: Journal of Biomolecular NMR. 64:207-221

In RNA secondary structure determination, it is essential to determine whether a nucleotide is base-paired and not. Base-pairing of nucleotides is mediated by hydrogen bonds. The NMR characterization of hydrogen bonds relies on experiments correlatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96229bb9d08bd07013129a97bc30ecc8
https://doi.org/10.1007/s10858-016-0021-5

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Chemo-Enzymatic Synthesis of Position-Specifically Modified RNA for Biophysical Studies including Light Control and NMR Spectroscopy

Autor: Alexander Heckel, Thomas Goldau, Harald Schwalbe, Anja Blümler, Sara Keyhani

Publikováno v: Angewandte Chemie (International ed. in English). 57(37)

The investigation of non-coding RNAs requires RNAs containing modifications at every possible position within the oligonucleotide. Here, we present the chemo-enzymatic RNA synthesis containing photoactivatable or 13 C,15 N-labelled nucleosides. All f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074f6b60f518ce7581c6fc67dd62cb46
https://pubmed.ncbi.nlm.nih.gov/30007102

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Rapid NMR screening of RNA secondary structure and binding

Autor: Christina Helmling, Florian Sochor, Martin Hengesbach, Harald Schwalbe, Sara Keyhani, Boris Fürtig

Publikováno v: Journal of Biomolecular NMR. 63:67-76

Determination of RNA secondary structures by NMR spectroscopy is a useful tool e.g. to elucidate RNA folding space or functional aspects of regulatory RNA elements. However, current approaches of RNA synthesis and preparation are usually time-consumi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62ab815e16158935abb84e2156dba18
https://doi.org/10.1007/s10858-015-9967-y

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