Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sara K. Powell"'
Autor:
R. Jude Samulski, Sara K. Powell, Martin O. Bohlen, Thomas J. McCown, Michele A. Basso, Hala G. El-Nahal, Tierney Daw, Marc A. Sommer
Publikováno v:
Hum Gene Ther
Recently, we established an adeno-associated virus (AAV9) capsid-promoter interaction that directly determined cell-specific gene expression across two synthetic promoters, Cbh and CBA, in the rat striatum. These studies not only expand this capsid-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288d75017ad53a1af701a638f309691e
https://doi.org/10.1089/hum.2020.196
https://doi.org/10.1089/hum.2020.196
Publikováno v:
Mol Ther
Cell-selective gene expression comprises a critical element of many adeno-associated virus (AAV) vector-based gene therapies, and to date achieving this goal has focused on AAV capsid engineering, cell-specific promoters, or cell-specific enhancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b972128e5b67ebf48d5f344da7db63
https://doi.org/10.1016/j.ymthe.2020.03.007
https://doi.org/10.1016/j.ymthe.2020.03.007
Autor:
Yu Zhang, John H Malone, Sara K Powell, Vipul Periwal, Eric Spana, David M Macalpine, Brian Oliver
Publikováno v:
PLoS Biology, Vol 8, Iss 2, p e1000320 (2010)
Extensive departures from balanced gene dose in aneuploids are highly deleterious. However, we know very little about the relationship between gene copy number and expression in aneuploid cells. We determined copy number and transcript abundance (exp
Externí odkaz:
https://doaj.org/article/7127762d6bd649c68e7de7096f362255
Autor:
Teresa M. Przytycka, Maria Patrizia Somma, Maurizio Gatti, Brenton R. Graveley, Justen Andrews, Dayu Zhang, Lucy Cherbas, Sara K. Powell, Matthew L. Eaton, Brian Oliver, Gemma E. May, David M. MacAlpine, Susan E. Celniker, Fioranna Renda, C. Joel McManus, Alissa M. Resch, Dong-Yeon Cho, Peter Cherbas, Lijun Zhan, Hangnoh Lee
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-3 (2019)
Following publication of the original article [1], the authors reported the following errors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943854332599954b4d7194acf79e621d
https://doi.org/10.1186/s13059-019-1668-5
https://doi.org/10.1186/s13059-019-1668-5
Autor:
Christina L. Parker, Steven J. Gray, G Matsushima, Thomas J. McCown, Sara K. Powell, N Khan, Richard Jude Samulski
Publikováno v:
Gene Therapy. 23:807-814
No adeno-associated virus (AAV) capsid has been described in the literature to exhibit a primary oligodendrocyte tropism when a constitutive promoter drives gene expression, which is a significant barrier for efficient in vivo oligodendrocyte gene tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a959ce5f26dfb6ed776908ed6f210c
https://doi.org/10.1038/gt.2016.62
https://doi.org/10.1038/gt.2016.62
Autor:
David M. MacAlpine, Joseph A. Prinz, Sara K. Powell, Heather K. MacAlpine, Yulong Li, Jason A. Belsky
Publikováno v:
The EMBO Journal. 34:531-543
Eukaryotic replication origins are defined by the ORC-dependent loading of the Mcm2-7 helicase complex onto chromatin in G1. Paradoxically, there is a vast excess of Mcm2-7 relative to ORC assembled onto chromatin in G1. These excess Mcm2-7 complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb991755d8977e5bedfdb1360a84cd2a
https://doi.org/10.15252/embj.201488307
https://doi.org/10.15252/embj.201488307
Autor:
Jason Halegoua, Bruce Ruggeri, Sara K. Powell, Maria Nelson, Joseph B. Mascarenhas, Deborah Lang
Publikováno v:
Molecular Carcinogenesis. 47:148-156
Tumors of the exocrine pancreas are a major cause of cancer death and have among the poorest prognosis of any malignancy. Following the "cancer stem cell hypothesis," where tumors are believed to originate in tissue specific stem cells, we screened p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::592fc6f766f85b0ba08002a3331b0c76
https://doi.org/10.1002/mc.20375
https://doi.org/10.1002/mc.20375
Autor:
Lucy Cherbas, Alissa M. Resch, Susan E. Celniker, Brenton R. Graveley, Maria Patrizia Somma, Peter Cherbas, Teresa M. Przytycka, Brian Oliver, C. Joel McManus, Gemma E. May, Sara K. Powell, Lijun Zhan, Dong-Yeon Cho, Hangnoh Lee, Dayu Zhang, David M. MacAlpine, Justen Andrews, Matthew L. Eaton, Maurizio Gatti, Fioranna Renda
Publikováno v:
Genome Biology
Genome biology (Online) 15 (2014). doi:10.1186/gb-2014-15-8-r70
info:cnr-pdr/source/autori:Lee, Hangnoh; McManus, C. Joel; Cho, Dong-Yeon; Eaton, Matthew; Renda, Fioranna; Somma, Maria Patrizia; Cherbas, Lucy; May, Gemma; Powell, Sara; Zhang, Dayu; Zhan, Lijun; Resch, Alissa; Andrews, Justen; Celniker, Susan E.; Cherbas, Peter; Przytycka, Teresa M.; Gatti, Maurizio; Oliver, Brian; Graveley, Brenton; MacAlpine, David/titolo:DNA copy number evolution in Drosophila cell lines/doi:10.1186%2Fgb-2014-15-8-r70/rivista:Genome biology (Online)/anno:2014/pagina_da:/pagina_a:/intervallo_pagine:/volume:15
Genome biology (Online) 15 (2014). doi:10.1186/gb-2014-15-8-r70
info:cnr-pdr/source/autori:Lee, Hangnoh; McManus, C. Joel; Cho, Dong-Yeon; Eaton, Matthew; Renda, Fioranna; Somma, Maria Patrizia; Cherbas, Lucy; May, Gemma; Powell, Sara; Zhang, Dayu; Zhan, Lijun; Resch, Alissa; Andrews, Justen; Celniker, Susan E.; Cherbas, Peter; Przytycka, Teresa M.; Gatti, Maurizio; Oliver, Brian; Graveley, Brenton; MacAlpine, David/titolo:DNA copy number evolution in Drosophila cell lines/doi:10.1186%2Fgb-2014-15-8-r70/rivista:Genome biology (Online)/anno:2014/pagina_da:/pagina_a:/intervallo_pagine:/volume:15
Background Structural rearrangements of the genome resulting in genic imbalance due to copy number change are often deleterious at the organismal level, but are common in immortalized cell lines and tumors, where they may be an advantage to cells. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b614425f5f903fdf140f0ab94d41a5
https://doi.org/10.1186/gb-2014-15-8-r70
https://doi.org/10.1186/gb-2014-15-8-r70
Autor:
Christina L. Parker, R. Jude Samulski, Glenn K. Matsushima, Nadia N. Khan, Sara K. Powell, Thomas J. McCown, Steven J. Gray
Publikováno v:
Molecular Therapy. 23:S123-S124
An AAV vector with oligodendrocyte-centric tropism would provide a valuable tool for research or for gene therapy in the treatment of demyelinating neurological disorders, such as ALS and multiple sclerosis. Using AAV capsid DNA shuffling we created
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0044a557b612b6714a5b662fa472f049
Autor:
Heather K. MacAlpine, David M. MacAlpine, Sara K. Powell, Raluca Gordân, Alexander J. Hartemink
Publikováno v:
Genome research. 20(2)
The origin recognition complex (ORC) is an essential DNA replication initiation factor conserved in all eukaryotes. In Saccharomyces cerevisiae, ORC binds to specific DNA elements; however, in higher eukaryotes, ORC exhibits little sequence specifici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f70838dac65406b7ec357df86f0b429
https://pubmed.ncbi.nlm.nih.gov/19996087
https://pubmed.ncbi.nlm.nih.gov/19996087