Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sara J. Thygesen"'
Autor:
Md. Habibur Rahaman, Sara J. Thygesen, Michael J. Maxwell, Hyoyoung Kim, Prerna Mudai, Jeffrey D. Nanson, Xinying Jia, Parimala R. Vajjhala, Andrew Hedger, Irina Vetter, Thomas Haselhorst, Avril A. B. Robertson, Brian Dymock, Thomas Ve, Mehdi Mobli, Katryn J. Stacey, Bostjan Kobe
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractToll-like receptor (TLR) innate immunity signalling protects against pathogens, but excessive or prolonged signalling contributes to a range of inflammatory conditions. Structural information on the TLR cytoplasmic TIR (Toll/interleukin-1 rec
Externí odkaz:
https://doaj.org/article/dcf8b7e19c924597be45dfa99851bf23
Autor:
Max T. B. Clabbers, Susannah Holmes, Timothy W. Muusse, Parimala R. Vajjhala, Sara J. Thygesen, Alpeshkumar K. Malde, Dominic J. B. Hunter, Tristan I. Croll, Leonie Flueckiger, Jeffrey D. Nanson, Md. Habibur Rahaman, Andrew Aquila, Mark S. Hunter, Mengning Liang, Chun Hong Yoon, Jingjing Zhao, Nadia A. Zatsepin, Brian Abbey, Emma Sierecki, Yann Gambin, Katryn J. Stacey, Connie Darmanin, Bostjan Kobe, Hongyi Xu, Thomas Ve
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
MAL and MyD88 are downstream adaptors of Toll-like receptors (TLR) and the MAL TIR domain forms filaments in vitro, which in turn nucleate the assembly of crystalline arrays of the MyD88 TIR domain. Here, the authors present the structure of these My
Externí odkaz:
https://doaj.org/article/5393cc79aa8d46d7b03a93a616d4e3b9
Autor:
Qian Yin, David P. Sester, Yuan Tian, Yu-Shan Hsiao, Alvin Lu, Jasmyn A. Cridland, Vitaliya Sagulenko, Sara J. Thygesen, Divaker Choubey, Veit Hornung, Thomas Walz, Katryn J. Stacey, Hao Wu
Publikováno v:
Cell Reports, Vol 4, Iss 2, Pp 327-339 (2013)
Mouse p202 containing two hemopoietic expression, interferon inducibility, nuclear localization (HIN) domains antagonizes AIM2 inflammasome signaling and potentially modifies lupus susceptibility. We found that only HIN1 of p202 binds double-stranded
Externí odkaz:
https://doaj.org/article/fa7b657ff5104c9eb2f915774c1f2ca5
Autor:
Andrew Aquila, Emma Sierecki, Chun Hong Yoon, Jingjing Zhao, Connie Darmanin, Tristan I. Croll, Md. Habibur Rahaman, Yann Gambin, Alpeshkumar K. Malde, Timothy W. Muusse, Parimala R. Vajjhala, Hongyi Xu, Max T. B. Clabbers, Sara J. Thygesen, Leonie Flueckiger, Mark S. Hunter, Brian Abbey, Bostjan Kobe, Nadia A. Zatsepin, Jeffrey D. Nanson, Katryn J. Stacey, Thomas Ve, Dominic J. B. Hunter, Susannah Holmes, Mengning Liang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications 12(1), 2578 (2021). doi:10.1038/s41467-021-22590-6
Nature Communications
Nature Communications 12(1), 2578 (2021). doi:10.1038/s41467-021-22590-6
MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms filaments in vitro and induces formation of crystalline higher-order asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de89df648be80cc1ecc2cd07ba2b8bad
Publikováno v:
The EMBO Journal. 39
Shigella,a major cause of bacterial dysentery, knows when it is not wanted. To generate and maintain its niche within host cells, this unwelcome guest injects several dozen virulence factors via a type 3 secretion system (T3SS). In this issue, Ashida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08ceead1e6e077b295f668313c919d9e
https://doi.org/10.15252/embj.2020106202
https://doi.org/10.15252/embj.2020106202
Autor:
Susannah Holmes, Max T. B. Clabbers, Timothy W. Muusse, Parimala R. Vajjhala, Sara J. Thygesen, Alpeshkumar K. Malde, Dominic J. B. Hunter, Tristan I. Croll, Leonie Flueckiger, Jeffrey D. Nanson, Md. Habibur Rahaman, Andrew Aquila, Mark S. Hunter, Mengning Liang, Chun Hong Yoon, Jingjing Zhao, Nadia A. Zatsepin, Brian Abbey, Emma Sierecki, Yann Gambin, Katryn J. Stacey, Connie Darmanin, Bostjan Kobe, Hongyi Xu, Thomas Ve
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 77:C849-C849
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::112692b9f5f87820efac81ca0bb920f1
https://doi.org/10.1107/s0108767321088498
https://doi.org/10.1107/s0108767321088498
Autor:
Sara J. Thygesen, Katryn J. Stacey
Publikováno v:
EMBO Rep
Caspase‐4, the cytosolic LPS sensor, and gasdermin D, its downstream effector, constitute the non‐canonical inflammasome, which drives inflammatory responses during Gram‐negative bacterial infections. It remains unclear whether other proteins r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa53b9e016c45294b1a36b2a3600325
https://pubmed.ncbi.nlm.nih.gov/31353801
https://pubmed.ncbi.nlm.nih.gov/31353801
Publikováno v:
Immunology & Cell Biology. 94:520-524
Inflammasomes are molecular complexes activated by infection and cellular stress, leading to caspase-1 activation and subsequent interleukin-1β (IL-1β) processing and cell death. The autoimmune NZB mouse strain does not express NLRP3, a key inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7134c36f131548d04658f648ecf39b
https://doi.org/10.1038/icb.2016.3
https://doi.org/10.1038/icb.2016.3
Autor:
Sara J. Thygesen
Inflammasomes are molecular complexes activated by infection and cellular stress, which are responsible for activating caspase-1 and subsequently facilitating interleukin (IL)-1β processing and macrophage cell death. It has been anticipated that exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::988c814f931987a25fe79ed3b04726fc
https://doi.org/10.14264/uql.2018.424
https://doi.org/10.14264/uql.2018.424