Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sara J Holditch"'
Autor:
Claire A Schreiber, Toshie Sakuma, Yoshihiro Izumiya, Sara J Holditch, Raymond D Hickey, Robert K Bressin, Upamanyu Basu, Kazunori Koide, Aravind Asokan, Yasuhiro Ikeda
Publikováno v:
PLoS Pathogens, Vol 11, Iss 8, p e1005082 (2015)
Adeno-associated viruses (AAV) have evolved to exploit the dynamic reorganization of host cell machinery during co-infection by adenoviruses and other helper viruses. In the absence of helper viruses, host factors such as the proteasome and DNA damag
Externí odkaz:
https://doaj.org/article/5782021d39314041814496d41ad5a7ef
Autor:
Emily M Eriksson, Teri Liegler, Chris E Keh, Annika C Karlsson, Sara J Holditch, Christopher D Pilcher, Lisa Loeb, Douglas F Nixon, Frederick M Hecht
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0120787 (2014)
CD8+ T cells are important for HIV-1 virus control, but are also a major contributing factor that drives HIV-1 virus sequence evolution. Although HIV-1 cytotoxic T cell (CTL) escape mutations are a common aspect during HIV-1 infection, less is known
Externí odkaz:
https://doaj.org/article/af3ee7af8c3f4e569eb034b7b7c28aeb
Autor:
Yu Cui, Mi Yeon Lee, Naxin Huo, Jennifer Bragg, Lijie Yan, Cheng Yuan, Cui Li, Sara J Holditch, Jingzhong Xie, Ming-Cheng Luo, Dawei Li, Jialin Yu, Joel Martin, Wendy Schackwitz, Yong Qiang Gu, John P Vogel, Andrew O Jackson, Zhiyong Liu, David F Garvin
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38333 (2012)
The ND18 strain of Barley stripe mosaic virus (BSMV) infects several lines of Brachypodium distachyon, a recently developed model system for genomics research in cereals. Among the inbred lines tested, Bd3-1 is highly resistant at 20 to 25 °C, where
Externí odkaz:
https://doaj.org/article/040b3664ddca4d5fb50b3b3f8a5e8302
Autor:
Sara J Holditch, Emily M Eriksson, Leandro F Tarosso, Peter J Kuebler, Esper G Kallas, Erik K Nielsen, Andrew A Wiznia, Michael G Rosenberg, Douglas F Nixon
Publikováno v:
Frontiers in Immunology, Vol 2 (2012)
The majority of infants born to HIV-1 positive women are exposed to the HIV-1 virus in utero or peri/post-partum, but are born uninfected. We, and others, have previously shown HIV-1 specific T cell responses in HIV-1 Exposed Seronegative (HESN) neon
Externí odkaz:
https://doaj.org/article/fac9863470754f70ba7a5d9fb5be8485
Autor:
Ryan C. Hill, Daniel J. Atwood, Andrew M. Lombardi, Deepak Pokhrel, Katharina Hopp, Carolyn N. Brown, Sara E Brown, Khoa N. Nguyen, Charles L. Edelstein, Mary C.M. Weiser-Evans, Miguel A. Lanaspa, Sara J. Holditch
Publikováno v:
Hum Mol Genet
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease, characterized by cyst formation and growth. Hyperproliferation is a major contributor to cyst growth. At the nexus of regulating proliferation, is 4E-BP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54eddd93f6b9e7697ba0e0d56ce94e0b
https://doi.org/10.1093/hmg/ddz244
https://doi.org/10.1093/hmg/ddz244
Autor:
Charles L. Edelstein, Khoa N. Nguyen, Daniel J. Atwood, Sara J. Holditch, Andrew M. Lombardi, Carolyn N. Brown, Harrison W. Toll, Katharina Hopp
Publikováno v:
American Journal of Physiology-Renal Physiology. 317:F187-F196
Autosomal dominant polycystic kidney disease (PKD) is characterized by cyst formation and growth, which are partially driven by abnormal proliferation of tubular cells. Proproliferative mechanistic target of rapamycin (mTOR) complexes 1 and 2 (mTORC1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a36bfb153ea5ecf809f17850c4fbe46e
https://doi.org/10.1152/ajprenal.00051.2019
https://doi.org/10.1152/ajprenal.00051.2019
Autor:
Carolyn N. Brown, Charles L. Edelstein, Daniel J. Atwood, Christopher Altmann, Sarah Faubel, Andrew Thorburn, Nataliya I. Skrypnyk, Sara J. Holditch, Judith Blaine, Jelena Klawitter, Jennifer N. Bourne, Deepak Pokhrel
Publikováno v:
Cell Death and Disease, Vol 12, Iss 3, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Many surgical models are used to study kidney and other diseases in mice, yet the effects of the surgical procedure itself on the kidney and other tissues have not been elucidated. In the present study, we found that both sham surgery and unilateral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e31818e45b6f5983555b94e7cfa9d9
https://doi.org/10.1038/s41419-021-03518-w
https://doi.org/10.1038/s41419-021-03518-w
Autor:
Deepak Pokhrel, Andrew Thorburn, Sara J. Holditch, Charles L. Edelstein, Katharina Hopp, Daniel J. Atwood, Dheevena M. Bachu, Carolyn N. Brown
Publikováno v:
Cellular signalling. 74
Cardiac hypertrophy is common in autosomal dominant polycystic kidney disease (ADPKD) patients. We found increased heart weight in Pkd1RC/RC and Pkd2WS25/+ mouse models of ADPKD. As there is a link between increased heart weight and mammalian target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810e1fe73edd06925cc9446763c8b6c3
https://pubmed.ncbi.nlm.nih.gov/32730856
https://pubmed.ncbi.nlm.nih.gov/32730856
Autor:
Sanskriti Saxena, Kameswaran Ravichandran, Carolyn N. Brown, Mary C.M. Weiser-Evans, Danica Galešić Ljubanović, Deepak Pokhrel, Melanie S. Joy, Raphael A. Nemenoff, Charles L. Edelstein, Daniel J. Atwood, Sara J. Holditch, Makoto Miyazaki
Publikováno v:
Cell Signal
In a clinically-relevant model of 4 week, low-dose cisplatin-induced AKI, mice were injected subcutaneously with non small cell lung cancer (NSCLC) cells that harbor an activating Kirsten rat sarcoma viral oncogene homolog (KRAS)G12V mutation. Phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8a28b7ee4b0487d6d2f77ac7214199
https://doi.org/10.1016/j.cellsig.2020.109605
https://doi.org/10.1016/j.cellsig.2020.109605
Autor:
Alessandro Cataliotti, Claire A. Schreiber, Nicholas F. LaRusso, Sara J. Holditch, Vicente E. Torres, Yasuhiro Ikeda, Peter C. Harris, Marina Ramirez-Alvarado
Publikováno v:
Kidney International. 92:657-668
Polycystic kidney disease (PKD) involves progressive hepatorenal cyst expansion and fibrosis, frequently leading to end-stage renal disease. Increased vasopressin and cAMP signaling, dysregulated calcium homeostasis, and hypertension play major roles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f396105a8b7b257f5a6a04f4c80270c2
https://doi.org/10.1016/j.kint.2017.02.017
https://doi.org/10.1016/j.kint.2017.02.017