Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Sara J Buhrlage"'
Autor:
Laura M Doherty, Caitlin E Mills, Sarah A Boswell, Xiaoxi Liu, Charles Tapley Hoyt, Benjamin Gyori, Sara J Buhrlage, Peter K Sorger
Publikováno v:
eLife, Vol 11 (2022)
Deubiquitinating enzymes (DUBs), ~100 of which are found in human cells, are proteases that remove ubiquitin conjugates from proteins, thereby regulating protein turnover. They are involved in a wide range of cellular activities and are emerging ther
Externí odkaz:
https://doaj.org/article/034ddeca640244579d9030d5250fe14c
Autor:
Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim
Publikováno v:
eLife, Vol 6 (2017)
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context
Externí odkaz:
https://doaj.org/article/8eec2bdf4b584beabb46e378e18f1d59
Autor:
Wai Cheung Chan, Xiaoxi Liu, Robert S. Magin, Nicholas M. Girardi, Scott B. Ficarro, Wanyi Hu, Maria I. Tarazona Guzman, Cara A. Starnbach, Alejandra Felix, Guillaume Adelmant, Anthony C. Varca, Bin Hu, Ariana S. Bratt, Ethan DaSilva, Nathan J. Schauer, Isabella Jaen Maisonet, Emma K. Dolen, Anthony X. Ayala, Jarrod A. Marto, Sara J. Buhrlage
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Deubiquitinases (DUBs) are key signaling enzymes, many of which lack selective inhibitors. Chan et al. pair a DUB-focused covalent library to mass spectrometry activity-based protein profiling, leading to selective hits against 23 endogenous DUBs and
Externí odkaz:
https://doaj.org/article/d6b807ef0bbf47468c2c964d3363d37f
Autor:
Patrick C. Lee, Susan Klaeger, Phuong M. Le, Keegan Korthauer, Jingwei Cheng, Varsha Ananthapadmanabhan, Thomas C. Frost, Jonathan D. Stevens, Alan Y.L. Wong, J. Bryan Iorgulescu, Anna Y. Tarren, Vipheaviny A. Chea, Isabel P. Carulli, Camilla K. Lemvigh, Christina B. Pedersen, Ashley K. Gartin, Siranush Sarkizova, Kyle T. Wright, Letitia W. Li, Jason Nomburg, Shuqiang Li, Teddy Huang, Xiaoxi Liu, Lucas Pomerance, Laura M. Doherty, Annie M. Apffel, Luke J. Wallace, Suzanna Rachimi, Kristen D. Felt, Jacquelyn O. Wolff, Elizabeth Witten, Wandi Zhang, Donna Neuberg, William J. Lane, Guanglan Zhang, Lars R. Olsen, Manisha Thakuria, Scott J. Rodig, Karl R. Clauser, Gabriel J. Starrett, John G. Doench, Sara J. Buhrlage, Steven A. Carr, James A. DeCaprio, Catherine J. Wu, Derin B. Keskin
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Cancers avoid immune surveillance through an array of mechanisms, including perturbation of HLA class I antigen presentation. Merkel cell carcinoma (MCC) is an aggressive, HLA-I–low, neuroendocrine carcinoma of the skin often caused by the Merkel c
Externí odkaz:
https://doaj.org/article/60397b52dbf342a38a8b4cfb3371eac6
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100896- (2021)
Summary: Identification of selective deubiquitinase (DUB) inhibitors is critical for probe development to further understand and explore DUB biological function. Here, we detail the optimization and deployment of an in vitro fluorogenic ubiquitin-rho
Externí odkaz:
https://doaj.org/article/a9c38f7b02f84904905e697a3e8f17d7
Autor:
He Zhu, J. Scott Mellors, Wai Cheung Chan, J. Will Thompson, Scott B. Ficarro, Isidoro Tavares, Ariana S. Bratt, Jens Decker, Michael Krause, Gary Kruppa, Sara J. Buhrlage, Jarrod A. Marto
Publikováno v:
Analytical Chemistry. 94:9508-9513
The family of deubiquitinases (DUBs) comprises ∼100 enzymes that cleave ubiquitin from substrate proteins and thereby regulate key aspects of human physiology. DUBs have recently emerged as disease-relevant and chemically tractable, although curren
Autor:
Kalindi Parmar, Alan D. D'Andrea, Nathanael S. Gray, Richard M. Stone, Ilene Galinsky, Gregory D. Cuny, Eunmi Park, Min Huang, Sara J. Buhrlage, Grace Hsieh, Helena Mistry
PDF - 90KB, Legends for Supplemental Figures 1 through 6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69434da057c51216cc2c84f429a1956a
https://doi.org/10.1158/1535-7163.22497586
https://doi.org/10.1158/1535-7163.22497586
Autor:
Kalindi Parmar, Alan D. D'Andrea, Nathanael S. Gray, Richard M. Stone, Ilene Galinsky, Gregory D. Cuny, Eunmi Park, Min Huang, Sara J. Buhrlage, Grace Hsieh, Helena Mistry
PDF - 502KB, Supplementary figure 1. USP1 inhibitor SJB2-043 inhibits activity of native USP1 in a dose-dependent manner and causes a decrease in ID1, ID2 and ID3 levels in K562 cells. Supplementary figure 2. Knockdown of USP1 results in growth inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3effc45a3ef446a4109b13c80a712c
https://doi.org/10.1158/1535-7163.22497583
https://doi.org/10.1158/1535-7163.22497583
Autor:
Kalindi Parmar, Alan D. D'Andrea, Nathanael S. Gray, Richard M. Stone, Ilene Galinsky, Gregory D. Cuny, Eunmi Park, Min Huang, Sara J. Buhrlage, Grace Hsieh, Helena Mistry
PDF - 86KB, Additional supplementary methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a98f50dab239b226523be513e19f2c
https://doi.org/10.1158/1535-7163.22497577.v1
https://doi.org/10.1158/1535-7163.22497577.v1
Autor:
Kalindi Parmar, Alan D. D'Andrea, Nathanael S. Gray, Richard M. Stone, Ilene Galinsky, Gregory D. Cuny, Eunmi Park, Min Huang, Sara J. Buhrlage, Grace Hsieh, Helena Mistry
Inhibitor of DNA binding 1 (ID1) transcription factor is essential for the proliferation and progression of many cancer types, including leukemia. However, the ID1 protein has not yet been therapeutically targeted in leukemia. ID1 is normally polyubi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663df1fda3afc37909c856e04a7d7989
https://doi.org/10.1158/1535-7163.c.6535660
https://doi.org/10.1158/1535-7163.c.6535660