Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Sara I. Liin"'
Publikováno v:
Channels, Vol 18, Iss 1 (2024)
The endogenous endocannabinoid-like compound N-arachidonoyl-L-serine (ARA-S) facilitates activation of the human Kv7.1/KCNE1 channel and shortens a prolonged action potential duration and QT interval in guinea pig hearts. Hence, ARA-S is interesting
Externí odkaz:
https://doaj.org/article/1ef725dfbecb4fecb8c477f3a3ab968b
Autor:
Irene Hiniesto-Iñigo, Laura M. Castro-Gonzalez, Valentina Corradi, Mark A. Skarsfeldt, Samira Yazdi, Siri Lundholm, Johan Nikesjö, Sergei Yu Noskov, Bo Hjorth Bentzen, D. Peter Tieleman, Sara I. Liin
Publikováno v:
EBioMedicine, Vol 89, Iss , Pp 104459- (2023)
Summary: Background: Genotype-positive patients who suffer from the cardiac channelopathy Long QT Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown causes. Therefore, there is a need to identify factors influencing dis
Externí odkaz:
https://doaj.org/article/68cc94b6c4f549b4b603e7aeba51442e
Autor:
Oliya S. Abdullaeva, Ihor Sahalianov, Malin Silverå Ejneby, Marie Jakešová, Igor Zozoulenko, Sara I. Liin, Eric Daniel Głowacki
Publikováno v:
Advanced Science, Vol 9, Iss 3, Pp n/a-n/a (2022)
Abstract H2O2 plays a significant role in a range of physiological processes where it performs vital tasks in redox signaling. The sensitivity of many biological pathways to H2O2 opens up a unique direction in the development of bioelectronics device
Externí odkaz:
https://doaj.org/article/e537b0ca1bff4f6786c208372dc3a2b7
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Voltage-gated potassium channels of the KV7 family are expressed in many tissues. The physiological importance of KV7 channels is evident from specific forms of disorders linked to dysfunctional KV7 channels, including variants of epilepsy, cardiac a
Externí odkaz:
https://doaj.org/article/a129530b003c4a6ea81216b70e5d1701
Publikováno v:
Cell Reports, Vol 24, Iss 11, Pp 2908-2918 (2018)
Summary: Polyunsaturated fatty acid (PUFA) analogs represent a new class of potential anti-arrhythmic KV7.1 and KV7.1+KCNE1 channel activators. In this study, we describe dual independent activating effects of negatively charged PUFA analogs on KV7.1
Externí odkaz:
https://doaj.org/article/1aad31143aca4177bd176e648363e273
Publikováno v:
eLife, Vol 11 (2022)
The KV7.4 and KV7.5 subtypes of voltage-gated potassium channels play a role in important physiological processes such as sound amplification in the cochlea and adjusting vascular smooth muscle tone. Therefore, the mechanisms that regulate KV7.4 and
Externí odkaz:
https://doaj.org/article/4a1c3bae62fd41169e4fabd9e94adbda
Autor:
Briana M Bohannon, Alicia de la Cruz, Xiaoan Wu, Jessica J Jowais, Marta E Perez, Derek M Dykxhoorn, Sara I Liin, H Peter Larsson
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://doaj.org/article/916e39ef8eff457f849713b47ca7bd82
Autor:
Briana M Bohannon, Alicia de la Cruz, Xiaoan Wu, Jessica J Jowais, Marta E Perez, Derek M Dykxhoorn, Sara I Liin, H Peter Larsson
Publikováno v:
eLife, Vol 9 (2020)
The cardiac ventricular action potential depends on several voltage-gated ion channels, including NaV, CaV, and KV channels. Mutations in these channels can cause Long QT Syndrome (LQTS) which increases the risk for ventricular fibrillation and sudde
Externí odkaz:
https://doaj.org/article/e07a4e0605884ed9905949525bae0d17
Voltage-gated potassium (KV) channels are important regulators of cellular excitability and control action potential repolarization in the heart and brain. KVchannel mutations lead to disordered cellular excitability. Loss-of-function mutations, for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03986ba4b524b6f111dc26714b02f583
https://doi.org/10.1101/2023.01.12.523777
https://doi.org/10.1101/2023.01.12.523777
Publikováno v:
eLife, Vol 7 (2018)
The voltage-gated potassium channel KV7.1 and the auxiliary subunit KCNE1 together form the cardiac IKs channel, which is a proposed target for future anti-arrhythmic drugs. We previously showed that polyunsaturated fatty acids (PUFAs) activate KV7.1
Externí odkaz:
https://doaj.org/article/76afcc4292c34739b5d68f68e35d6b4e