AmotL2 integrates polarity and junctional cues to modulate cell shape

Autor: Sara Hultin, Aravindh Subramani, Sebastian Hildebrand, Yujuan Zheng, Arindam Majumdar, Lars Holmgren

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Abstract The assembly of individual epithelial or endothelial cells into a tight cellular sheet requires stringent control of cell packing and organization. These processes are dependent on the establishment and further integration of cellular juncti

Externí odkaz: https://doaj.org/article/3f0edef230f64693b0028e366debdf52

Spinal cord injury in zebrafish induced by near-infrared femtosecond laser pulses

Autor: Sandra Ceccatelli, Sara Hultin, Stefan Spulber, Per Uhlén, Claes Hultling, Ivar Dehnisch Ellström, Nils Norlin

Publikováno v: Journal of neuroscience methods. 311

Background The spinal cord is composed of a large number of cells that interact to allow the organism to function. To perform detail studies of cellular processes involved in spinal cord injury (SCI), one must use repeatable and specific methods to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37018f783756a1f34ddf971afab22ab
https://pubmed.ncbi.nlm.nih.gov/30389486

The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching

Autor: Yuanyuan Zhang, Arindam Majumdar, Sophie Petropoulos, Lars Holmgren, Sebastian Hildebrand, Fredrik Lanner, J P Mpindi, Xiaofang Cao, Sara Hultin, Olli Kalloniemi, Aravindh Subramani, Staffan Johansson

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Scientific Reports
Hildebrand, S, Hultin, S, Subramani, A, Petropoulos, S, Zhang, Y, Cao, X, Mpindi, J, Kalloniemi, O, Johansson, S, Majumdar, A, Lanner, F & Holmgren, L 2017, ' The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching ', Scientific Reports, vol. 7, no. 1, 9540 . https://doi.org/10.1038/s41598-017-10102-w

Epithelial cells connect via cell-cell junctions to form sheets of cells with separate cellular compartments. These cellular connections are essential for the generation of cellular forms and shapes consistent with organ function. Tissue modulation i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a633b8333e5b272374140b7b733dd5
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-339873

AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion

Autor: Frédérique Lembo, Marja Hallström, Lars Holmgren, Sara Hultin, Claes Lenander, Per Johnsson, Martin Corcoran, Per Uhlén, Nathalie M. Mazure, Christin Mieth, Stéphane Audebert, Mahdi Mojallal, Thomas Weide, Dan Grandér, Nicolas Fritz, Tanja van Harn, Yujuan Zheng, Jean-Paul Borg, Johan Hartman

Publikováno v: Nature communications. 5

The establishment and maintenance of apical-basal cell polarity is essential for the functionality of glandular epithelia. Cell polarity is often lost in advanced tumours correlating with acquisition of invasive and malignant properties. Despite exte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb81fc12d0e2c06c12b8f14558c0ed5
https://pubmed.ncbi.nlm.nih.gov/25080976

Abstract A12: AmotL2 linking hypoxia to invasion

Autor: Sara Hultin, Lars Holmgren, Mahdi Mojallal, Yujuan Zheng

Publikováno v: Cancer Research. 71:A12-A12

Hypoxia has been shown to be a bad prognostic marker correlating with metastasis and poor survival. Furthermore, in response to antiangiogenic therapy hypoxic tumor cells become invasive and form metastasis. Malignant tumor cells undergo epithelial-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c262eaa1c147b0656a6efb6a9b6d93a8
https://doi.org/10.1158/1538-7445.fbcr11-a12