Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Sara Horta"'
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Evaluation of Immuno-Rolling Circle Amplification for Multiplex Detection and Profiling of Antigen-Specific Antibody Isotypes
Autor: Nick Geukens, Sara Horta, Narayanan Madaboosi, Karen Vanhoorelbeke, Jeroen Lammertyn, Shu-hao Yeh, Christoffer Mattsson Langseth, Jolien Breukers, Mats Nilsson, Kadri Kangro, Felix Neumann
Publikováno v: Analytical Chemistry. 93:6169-6177
Antibody characterization is essential for understanding the immune system and development of diagnostics and therapeutics. Current technologies are mainly focusing on the detection of antigen-specific immunoglobulin G (IgG) using bulk singleplex mea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5702b70cb0c9f1e12dda7f4abc95974
https://doi.org/10.1021/acs.analchem.1c00172
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3
Miniaturized single-cell technologies for monoclonal antibody discovery
Autor: Karen Vanhoorelbeke, Paul Declerck, Jolien Breukers, Sara Horta, Francesca Pollet, Nick Geukens, Julie van Lent, Karen Ven, Maya Imbrechts, Louanne Ampofo, Jeroen Lammertyn
Publikováno v: Lab on a Chip. 21:3627-3654
Antibodies (Abs) are among the most important class of biologicals, showcasing a high therapeutic and diagnostic value. In the global therapeutic Ab market, fully-human monoclonal Abs (FH-mAbs) are flourishing thanks to their low immunogenicity and h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8af9b5bcd27e600643ff8eee3913bf
https://doi.org/10.1039/d1lc00243k
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4
Expanding a Portfolio of (FO-) SPR Surface Chemistries with the Co(III)-NTA Oriented Immobilization of His6-Tagged Bioreceptors for Applications in Complex Matrices
Autor: Jia-Huan Qu, Karen Vanhoorelbeke, Filip Delport, Dragana Spasic, Nick Geukens, Jeroen Lammertyn, Da-Wen Sun, Sara Horta, Machteld Sillen, Paul Declerck
Publikováno v: ACS Sensors. 5:960-969
Cobalt-nitrilotriacetic acid (Co(III)-NTA) chemistry is a recognized approach for oriented patterning of His6-tagged bioreceptors. We have applied the matching strategy for the first time on a surface plasmon resonance (SPR) platform, namely, the com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c704e27da459cf3e96b67a4a4114a4d0
https://doi.org/10.1021/acssensors.9b02227
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5
Tuning the Surface Interactions between Single Cells and an OSTE+ Microwell Array for Enhanced Single Cell Manipulation
Autor: Jolien Breukers, Bruno P. A. Cammue, Caroline Struyfs, Dragana Spasic, Hendrik B. Feys, Jeroen Lammertyn, Karin Thevissen, Sara Horta, Karen Vanhoorelbeke, Nick Geukens
Retrieving single cells of interest from an array of microwells for further off-chip analysis is crucial in numerous biological applications. To this end, several single cell manipulation strategies have been developed, including optical tweezers (OT
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6e00aee7bc968ffa5903609eb81326
https://lirias.kuleuven.be/handle/123456789/673979
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Co(III)-NTA Mediated Antigen Immobilization on a Fiber Optic-SPR Biosensor for Detection of Autoantibodies in Autoimmune Diseases: Application in Immune-Mediated Thrombotic Thrombocytopenic Purpura
Autor: Jia-Huan Qu, Quintijn Bonnez, Edwige Tellier, Gilles Kaplanski, Jeroen Lammertyn, Charlotte Dekimpe, Karen Vanhoorelbeke, Aline Vandenbulcke, Nick Geukens, Sara Horta, Filip Delport
Publikováno v: Analytical Chemistry
Analytical Chemistry, 2020, 92 (20), pp.13880-13887. ⟨10.1021/acs.analchem.0c02586⟩
Analytical Chemistry, American Chemical Society, 2020, 92 (20), pp.13880-13887. ⟨10.1021/acs.analchem.0c02586⟩
Autoantibodies are key biomarkers in clinical diagnosis of autoimmune diseases routinely detected by enzyme-linked immunosorbent assays (ELISAs). However, the complexity of these assays is limiting their use in routine diagnostics. Fiber optic-surfac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499f71260855c62645f340ed19645d4d
https://hal.inrae.fr/hal-03155879
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8
Increased frequencies of circulating CXCL10-, CXCL8- and CCL4-producing monocytes and Siglec-3-expressing myeloid dendritic cells in systemic sclerosis patients
Autor: José António Pereira da Silva, Joel A G van Roon, Tiago Carvalheiro, Hélder Trindade, Maria João Salvador, Timothy R D J Radstake, Sara Horta, Mariana Santiago, Artur Paiva
Publikováno v: Inflammation Research, 67(2), 169. Birkhauser Verlag Basel
Inflammation Research
Objective To investigate the ex vivo pro-inflammatory properties of classical and non-classical monocytes as well as myeloid dendritic cells (mDCs) in systemic sclerosis (SSc) patients. Methods Spontaneous production of CXCL10, CCL4, CXCL8 and IL-6 w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3ae9b84f1165de1b54f4aa0d83cccb
https://dspace.library.uu.nl/handle/1874/388466
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9
Implications of Akt2/Twist crosstalk on breast cancer metastatic outcome
Autor: Rita Mateus, Lucília Pereira, Sara Horta, Mafalda Videira
Publikováno v: Drug Discovery Today. 20:1152-1158
Akt2 is a pivotal player in a complex web of signaling pathways controlling cell growth, proliferation, and survival. The deregulation or aberrations of Akt2 have been associated with tumor progression, metastatic spread, and, lastly, chemoresistance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7374cfbf014f3d41af5c01c3dc7a70
https://doi.org/10.1016/j.drudis.2015.06.010
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SAT0324 Increased frequencies of circulating CXCL10-, CXCL8- and CCL4-producing monocytes and SIGLEC-3-expressing myeloid dendritic cells in systemic sclerosis patients
Autor: Tiago Carvalheiro, Sara Horta, M. Santiago, Alexandre Paiva, Maria João Salvador, J.A. van Roon, Hélder Trindade, J. A. P. Da Silva, Trdj Radstake
Publikováno v: Poster Presentations.
Background Systemic sclerosis (SSc) is an inflammatory and fibrotic disease characterized by vascular dysfunction, excessive extracellular matrix deposition and immune dysregulation. Recent observations suggest that monocytes and dendritic cells (DCs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::892916cd2e72f4128f09fd8b168e5278
https://doi.org/10.1136/annrheumdis-2017-eular.5050
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