Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sara Hegazi"'
Autor:
Sara Hegazi, Arthur H. Cheng, Joshua J. Krupp, Takafumi Tasaki, Jiashu Liu, Daniel A. Szulc, Harrod H. Ling, Julian Rios Garcia, Shavanie Seecharran, Tayebeh Basiri, Mehdi Amiri, Zobia Anwar, Safa Ahmad, Kamar Nayal, Nahum Sonenberg, Bao-Hua Liu, Hai-Ling Margaret Cheng, Joel D. Levine, Hai-Ying Mary Cheng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Although ubiquitin ligases are known to control clock protein degradation, their other roles in clock neurons are unclear. Here the authors report that UBR4 promotes export of neuropeptides from the Golgi for axonal trafficking, which is important fo
Externí odkaz:
https://doaj.org/article/605a3146a00649c9a7bc55bd226e5c42
Publikováno v:
Neurology International, Vol 13, Iss 4, Pp 541-554 (2021)
Mood disorders negatively impact the lives of hundreds of millions of individuals worldwide every year, yet the precise molecular mechanisms by which they manifest remain elusive. Circadian dysregulation is one avenue by which mood disorders are thou
Externí odkaz:
https://doaj.org/article/72ebb77bc8ec418e85ba531e078f562c
Autor:
Arthur H. Cheng, Samuel W. Fung, Sara Hegazi, Osama Hasan Mustafa Hasan Abdalla, Hai-Ying Mary Cheng
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 229 (2021)
In mammals, the hypothalamic suprachiasmatic nucleus (SCN) functions as the central circadian pacemaker, orchestrating behavioral and physiological rhythms in alignment to the environmental light/dark cycle. The neurons that comprise the SCN are anat
Externí odkaz:
https://doaj.org/article/8891db609ffd4ac09a8556ae26e92a78
Autor:
Lucia Mendoza-Viveros, Cheng-Kang Chiang, Jonathan L.K. Ong, Sara Hegazi, Arthur H. Cheng, Pascale Bouchard-Cannon, Michael Fana, Christopher Lowden, Peng Zhang, Béatrice Bothorel, Matthew G. Michniewicz, Stephen T. Magill, Melissa M. Holmes, Richard H. Goodman, Valérie Simonneaux, Daniel Figeys, Hai-Ying M. Cheng
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 505-520 (2017)
Summary: The central circadian pacemaker, the suprachiasmatic nucleus (SCN), encodes day length information by mechanisms that are not well understood. Here, we report that genetic ablation of miR-132/212 alters entrainment to different day lengths a
Externí odkaz:
https://doaj.org/article/d3b0855d59fe4e8dbbe648ccb826eaa2
Autor:
Arthur H. Cheng, Pascale Bouchard-Cannon, Sara Hegazi, Christopher Lowden, Samuel W. Fung, Cheng-Kang Chiang, Rob W. Ness, Hai-Ying Mary Cheng
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3191-3202.e8 (2019)
Summary: Clock neurons within the mammalian suprachiasmatic nuclei (SCN) encode circadian time using interlocked transcription-translation feedback loops (TTFLs) that drive rhythmic gene expression. However, the contributions of other transcription f
Externí odkaz:
https://doaj.org/article/25cf270b5faf464e810e8f443f026faf
Autor:
Sara Hegazi, Christopher Lowden, Julian Rios Garcia, Arthur H. Cheng, Karl Obrietan, Joel D. Levine, Hai-Ying Mary Cheng
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2363 (2019)
The central pacemakers of circadian timekeeping systems are highly robust yet adaptable, providing the temporal coordination of rhythms in behavior and physiological processes in accordance with the demands imposed by environmental cycles. These feat
Externí odkaz:
https://doaj.org/article/8f8f91c5047148d2a82d34ef8180db4d
Publikováno v:
Neurology International
Neurology International, Vol 13, Iss 54, Pp 541-554 (2021)
Volume 13
Issue 4
Pages 54-554
Neurology International, Vol 13, Iss 54, Pp 541-554 (2021)
Volume 13
Issue 4
Pages 54-554
Mood disorders negatively impact the lives of hundreds of millions of individuals worldwide every year, yet the precise molecular mechanisms by which they manifest remain elusive. Circadian dysregulation is one avenue by which mood disorders are thou
Autor:
Sara Hegazi, Arthur H. Cheng, Joshua J. Krupp, Takafumi Tasaki, Jiashu Liu, Daniel A. Szulc, Harrod H. Ling, Julian Rios Garcia, Shavanie Seecharran, Tayebeh Basiri, Mehdi Amiri, Zobia Anwar, Safa Ahmad, Kamar Nayal, Nahum Sonenberg, Bao-Hua Liu, Hai-Ling Margaret Cheng, Joel D. Levine, Hai-Ying Mary Cheng
Publikováno v:
Nature communications. 13(1)
Ubiquitin ligases control the degradation of core clock proteins to govern the speed and resetting properties of the circadian pacemaker. However, few studies have addressed their potential to regulate other cellular events within clock neurons beyon
Autor:
Pascale Bouchard-Cannon, Daniel Figeys, Sara Hegazi, Peng Zhang, Arthur H. Cheng, Christopher Lowden, Lucia Mendoza-Viveros, Valérie Simonneaux, Cheng-Kang Chiang, Béatrice Bothorel, Stephen T. Magill, Jonathan L.K. Ong, Matthew G. Michniewicz, Richard H. Goodman, Melissa M. Holmes, Michael Fana, Hai-Ying M. Cheng
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 505-520 (2017)
Cell reports
Cell Reports
Cell Reports, Elsevier Inc, 2017, 19 (3), pp.505-520. ⟨10.1016/j.celrep.2017.03.057⟩
Cell reports
Cell Reports
Cell Reports, Elsevier Inc, 2017, 19 (3), pp.505-520. ⟨10.1016/j.celrep.2017.03.057⟩
Summary: The central circadian pacemaker, the suprachiasmatic nucleus (SCN), encodes day length information by mechanisms that are not well understood. Here, we report that genetic ablation of miR-132/212 alters entrainment to different day lengths a
Autor:
Lucia Mendoza-Viveros, Sara Hegazi, Pascale Bouchard-Cannon, Arthur H. Cheng, Stephen Pastore, Hai-Ying M. Cheng
Publikováno v:
Cellular and Molecular Life Sciences. 74:1035-1059
Circadian timekeeping is a ubiquitous mechanism that enables organisms to maintain temporal coordination between internal biological processes and time of the local environment. The molecular basis of circadian rhythms lies in a set of transcription-