Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sara H. Weitz"'
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 1994-2005 (2014)
Canonical primary microRNA transcripts (pri-miRNAs) are characterized by a ∼30 bp hairpin flanked by single-stranded regions. These pri-miRNAs are recognized and cleaved by the Microprocessor complex consisting of the Drosha nuclease and its obliga
Externí odkaz:
https://doaj.org/article/a04e1f2a41384f83b98665871da5d383
Autor:
Joseph C. Chen, Zuguang Wang, Hong Huang, Sara H. Weitz, Aprilgate Wang, Xiaolei Qiu, Mark A. Baumeister, Arejas Uzgiris
Publikováno v:
International Journal of Infectious Diseases, Vol 51, Iss C, Pp 139-140 (2016)
Externí odkaz:
https://doaj.org/article/e0f2e0a4063341e49e393fec79f947dc
Autor:
Jen Quick-Cleveland, Sara H. Weitz, Shimon Weiss, Jose Jacob, Kikuye Koyano, Xinshu Xiao, Feng Guo, Ian G. Barr, Rachel Senturia
The essential biological cofactor heme is synthesized in cells in the Fe(II) form. Oxidized Fe(III) heme is specifically required for processing primary transcripts of microRNAs (pri-miRNAs) by the RNA-binding protein DGCR8, a core component of the M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f3765188eb2dae8deedfbe91c1e283
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 5
Weitz, SH; Gong, M; Barr, I; Weiss, S; & Guo, F. (2014). Processing of microRNA primary transcripts requires heme in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America, 111(5), 1861-1866. doi: 10.1073/pnas.1309915111. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4n53x5rb
Weitz, SH; Gong, M; Barr, I; Weiss, S; & Guo, F. (2014). Processing of microRNA primary transcripts requires heme in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America, 111(5), 1861-1866. doi: 10.1073/pnas.1309915111. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4n53x5rb
DiGeorge syndrome critical region gene 8 (DGCR8) is the RNA-binding partner protein of the nuclease Drosha. DGCR8 and Drosha recognize and cleave primary transcripts of microRNAs (pri-miRNAs) in the maturation of canonical microRNAs (miRNAs) in anima
Autor:
Joseph A. Gogos, Sara H. Weitz, Talia Atkin, Feng Guo, Pei Ken Hsu, Maria Karayiorgou, Ian G. Barr, Shimon Weiss
Publikováno v:
Barr, I; Weitz, SH; Atkin, T; Hsu, P; Karayiorgou, M; Gogos, JA; et al.(2015). Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency. Chemistry and Biology, 22(6), 793-802. doi: 10.1016/j.chembiol.2015.05.015. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7v83f898
Chemistry & biology, vol 22, iss 6
Chemistry & biology, vol 22, iss 6
© 2015 Elsevier Ltd All rights reserved. Summary Processing of microRNA primary transcripts (pri-miRNAs) is highly regulated and defects in the processing machinery play a key role in many human diseases. In 22q11.2 deletion syndrome (22q11.2DS), he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295a08d317184ea9fbf75b8875aab872
http://www.escholarship.org/uc/item/7v83f898
http://www.escholarship.org/uc/item/7v83f898
Autor:
Mark A. Baumeister, Hong Huang, Aprilgate Wang, Zuguang Wang, Xiaolei Qiu, Sara H. Weitz, Arejas Uzgiris, Joseph C. Chen
Publikováno v:
International Journal of Infectious Diseases, Vol 51, Iss C, Pp 139-140 (2016)
Publikováno v:
Cell reports, vol 7, iss 6
Cell Reports, Vol 7, Iss 6, Pp 1994-2005 (2014)
Quick-Cleveland, J; Jacob, JP; Weitz, SH; Shoffner, G; Senturia, R; & Guo, F. (2014). The DGCR8 RNA-Binding Heme Domain Recognizes Primary MicroRNAs by Clamping the Hairpin. Cell Reports, 7(6), 1994-2005. doi: 10.1016/j.celrep.2014.05.013. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2rw6m6jt
Cell Reports, Vol 7, Iss 6, Pp 1994-2005 (2014)
Quick-Cleveland, J; Jacob, JP; Weitz, SH; Shoffner, G; Senturia, R; & Guo, F. (2014). The DGCR8 RNA-Binding Heme Domain Recognizes Primary MicroRNAs by Clamping the Hairpin. Cell Reports, 7(6), 1994-2005. doi: 10.1016/j.celrep.2014.05.013. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2rw6m6jt
Canonical primary microRNA transcripts (pri-miRNAs) are characterized by a ~30bp hairpin flanked by single-stranded regions. These pri-miRNAs are recognized and cleaved by the Microprocessor complex consisting of the Drosha nuclease and its obligate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c384938c32c1dd823eeec331760ff3d9
https://escholarship.org/uc/item/2rw6m6jt
https://escholarship.org/uc/item/2rw6m6jt
Autor:
Aprilgate Wang, Aileen Shields, Harwinder Sidhu, Arejas Uzgiris, Zuguang Wang, Erik Sudin, Malcolm S. Shields, Sara H. Weitz, Joseph C. Chen, Derek Ostertag
Publikováno v:
Journal of Clinical Oncology. 34:e13508-e13508
e13508Background: Toca 511 (vocimagene amiretrorepvec) is an investigational retroviral replicating vector that encodes the transgene cytosine deaminase. Toca 511 is delivered by multiple routes an...