Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sara H. Thrall"'
Autor:
Rosalie Matico, Wangfang Hou, Thomas D. Meek, Sara H. Thrall, Patrick McDevitt, Jessica L. Schneck, Johnson Neil W, Myles B. Poulin, Michael J. Huddleston, Vern L. Schramm
Publikováno v:
Proceedings of the National Academy of Sciences. 113:1197-1201
Nuclear receptor SET domain containing protein 2 (NSD2) catalyzes the methylation of histone H3 lysine 36 (H3K36). It is a determinant in Wolf-Hirschhorn syndrome and is overexpressed in human multiple myeloma. Despite the relevance of NSD2 to cancer
Autor:
Beth Pietrak, Sharon Sweitzer, Alan R. Rendina, Chad Quinn, Nestor O. Concha, Chaya Duraiswami, Huizhen Zhao, Angela Smallwood, Sara H. Thrall, Nicholas D. Adams, Benjamin Schwartz, Hongwei Qi
Publikováno v:
Biochemistry. 52:4563-4577
The human, cytosolic enzyme isocitrate dehydrogenase 1 (IDH1) reversibly converts isocitrate to α-ketoglutarate (αKG). Cancer-associated somatic mutations in IDH1 result in a loss of this normal function but a gain in a new or neomorphic ability to
Autor:
Thomas D. Meek, Angela Smallwood, Jessica L. Schneck, Sara H. Thrall, Amy N. Taylor, Baoguang Zhao, Jon K. Rubach, Neysa Nevins, Guanglei Cui, David D. Wisnoski
Publikováno v:
Biochemistry. 51:7551-7568
We examined the cathepsin C-catalyzed hydrolysis of dipeptide substrates of the form Yaa-Xaa-AMC, using steady-state and pre-steady-state kinetic methods. The substrates group into three kinetic profiles based upon the broad range observed for k(cat)
Autor:
Mehul Patel, Andrea H. Epperly, Gale Jennifer Paul, Pamela L. Golden, Hu Li, Frank T. Coppo, Daphne C. Clancy, Yue H. Li, Todd L. Graybill, David G. Tew, Francis X. Tavares, Joyce A. Boucheron, Stephen A. Thomson, Karen A. Evans, James E. Weiel, Maria Cichy-Knight, Sara H. Thrall
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4068-4071
A series of amino acid anthranilamide derivatives identified from a high-throughput screening campaign as novel, potent, and glucose-sensitive inhibitors of human liver glycogen phosphorylase a are described. A solid-phase synthesis using Wang resin
Autor:
Sara H. Thrall, Rosalie Matico, Michael Jaye, Paul M. Keller, Benjamin J. Schwartz, Timothy Rust, Dennis J. Murphy, Anthony J. Jurewicz, Krawiec John A, Mark R. Harpel, John J. Trill
Publikováno v:
SLAS Discovery. 13:468-475
Endothelial lipase (EL) is a 482-amino-acid protein from the triglyceride lipase gene family that uses a Ser-His-Asp triad for catalysis. Its expression in endothelial cells and preference for phospholipids rather than triglycerides are unique. Anima
Autor:
Kyung O. Johanson, Thau F. Ho, Anthony J. Jurewicz, Benjamin J. Schwartz, Jianhong Ma, Sara H. Thrall, Leng A. Lor, John D. Martin, Robert B. Kirkpatrick, Monique F. Murray, Hong Zhang
Publikováno v:
SLAS Discovery. 12:1050-1058
Tumor suppressor p53 is typically maintained at low levels in normal cells. In response to cellular stresses, such as DNA damage, p53 is stabilized and can stimulate responses leading to cell cycle arrest or apoptosis. Corresponding to its central ro
Autor:
Sara H. Thrall, Martin Brandt, Leng A. Lor, Jessica L. Schneck, Elsie Diaz, Benjamin K. Schwartz, Dean E. McNulty
Publikováno v:
SLAS Discovery. 12:881-890
In addition to selecting molecules of pharmacological interest, high-throughput screening campaigns often generate hits of undesirable mechanism, which cannot be exploited for drug discovery as they lead to obvious problems of specificity and develop
Publikováno v:
Biochemistry. 44:16753-16765
Beta-ketoacyl-acyl carrier protein reductase (KACPR) catalyzes the NADPH-dependent reduction of beta-ketoacyl-acyl carrier protein (AcAc-ACP) to generate (3S)-beta-hydroxyacyl-ACP during the chain-elongation reaction of bacterial fatty acid biosynthe
Publikováno v:
Biochemistry. 37:13349-13358
Single-turnover and equilibrium measurements were carried out to determine the basis of the apparently slow, nonprocessive polymerization reaction catalyzed by HIV-1 reverse transcriptase (RT) during transcription initiation, when both the primer and
Autor:
Ruth Krebs, Stuart F. J. Le Grice, Sara H. Thrall, Birgitta M. Wöhrl, Axel J. Scheidig, Roger S. Goody
Publikováno v:
Journal of Biological Chemistry. 272:17581-17587
The highly conserved primer grip region in the p66 subunit of HIV-1 reverse transcriptase (RT) is formed by the β12-β13 hairpin (residues 227–235). It has been proposed to play a role in aligning the 3′-OH end of the primer in a position for nu