Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sara Gelino"'
Autor:
Philip R. McQuary, Chen-Yu Liao, Jessica T. Chang, Caroline Kumsta, Xingyu She, Andrew Davis, Chu-Chiao Chu, Sara Gelino, Rafael L. Gomez-Amaro, Michael Petrascheck, Laurence M. Brill, Warren C. Ladiges, Brian K. Kennedy, Malene Hansen
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2059-2067 (2016)
Deficiency of S6 kinase (S6K) extends the lifespan of multiple species, but the underlying mechanisms are unclear. To discover potential effectors of S6K-mediated longevity, we performed a proteomics analysis of long-lived rsks-1/S6K C. elegans mutan
Externí odkaz:
https://doaj.org/article/29b2484ea09e4ed5ac62471d7032b3bc
Autor:
Sara Gelino, Jessica T Chang, Caroline Kumsta, Xingyu She, Andrew Davis, Christian Nguyen, Siler Panowski, Malene Hansen
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006271 (2016)
[This corrects the article DOI: 10.1371/journal.pgen.1006135.].
Externí odkaz:
https://doaj.org/article/ee31d33163ed4ad7b05442c90c27e654
Autor:
Sara Gelino, Jessica T Chang, Caroline Kumsta, Xingyu She, Andrew Davis, Christian Nguyen, Siler Panowski, Malene Hansen
Publikováno v:
PLoS Genetics, Vol 12, Iss 7, p e1006135 (2016)
Dietary restriction (DR) is a dietary regimen that extends lifespan in many organisms. One mechanism contributing to the conserved effect of DR on longevity is the cellular recycling process autophagy, which is induced in response to nutrient scarcit
Externí odkaz:
https://doaj.org/article/17d396084ddd47d28e13dfa777e78a73
Autor:
Alexander Martin Heberle, Bettina Warscheid, Birgit Holzwarth, Sara Gelino, Miriam Langelaar-Makkinje, Malene Hansen, Chris Meisinger, Carolin Gerbeth, Ralf Baumeister, Jennifer J. Schwarz, Marcel A. T. M. van Vugt, Kathrin Thedieck, Deepti S. Wilkinson, Stefanie Ruf
Publikováno v:
Autophagy, 13(3), 486-505. Taylor & Francis Group
Autophagy
Autophagy
Mechanistic target of rapamycin complex 1 (MTORC1) and polo like kinase 1 (PLK1) are major drivers of cancer cell growth and proliferation, and inhibitors of both protein kinases are currently being investigated in clinical studies. To date, MTORC1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc92a92c9ce40bfe02f955479d1c2a34
https://research.rug.nl/en/publications/7e875278-2318-4f08-bfda-6538fdaa4f66
https://research.rug.nl/en/publications/7e875278-2318-4f08-bfda-6538fdaa4f66
Autor:
Chen-Yu Liao, Xingyu She, Brian K. Kennedy, Malene Hansen, Jessica T. Chang, Philip McQuary, Rafael L. Gomez-Amaro, Warren C. Ladiges, Chu Chiao Chu, Sara Gelino, Laurence M. Brill, Michael Petrascheck, Caroline Kumsta, Andrew Davis
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2059-2067 (2016)
SummaryDeficiency of S6 kinase (S6K) extends the lifespan of multiple species, but the underlying mechanisms are unclear. To discover potential effectors of S6K-mediated longevity, we performed a proteomics analysis of long-lived rsks-1/S6K C. elegan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faad9f93ce097545288f7f29a6f22a24
https://europepmc.org/articles/PMC4823261/
https://europepmc.org/articles/PMC4823261/
Autor:
Elizabeth S. Didier, Miguel Coelho, Iain Ridgway, Tracy T. Chow, Paul W. Whitby, Insil Kim, Eva E. R. Philipp, Philip McQuary, William E. Sonntag, Courtney M. Campbell, Sara Gelino, Zoltan Ungvari, Marissa A. Holmbeck, Danuta Sosnowska, Anna Csiszar, Steven N. Austad, Erik Levy
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 68:359-367
Bivalve species with exceptional longevity are newly introduced model systems in biogerontology to test evolutionarily conserved mechanisms of aging. Here, we tested predictions based on the oxidative stress hypothesis of aging using one of the tropi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6fe9f002bc70dba00985f80a47df37
https://doi.org/10.1093/gerona/gls159
https://doi.org/10.1093/gerona/gls159
Publikováno v:
Current Biology. 21:1507-1514
Summary Background: The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autopha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047274adb77591282dc4e4a850efd87e
https://doi.org/10.1016/j.cub.2011.07.042
https://doi.org/10.1016/j.cub.2011.07.042
Autor:
Insil Kim, Eva E. R. Philipp, Sara Gelino, Philip McQuary, Danuta Sosnowska, Steven N. Austad, William E. Sonntag, Tracy T. Chow, Elizabeth S. Didier, Iain Ridgway, Marissa A. Holmbeck, Zoltan Ungvari, Anna Csiszar, Erik Levy, Miguel Coelho, Courtney M. Campbell
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. :741-750
We assess whether reactive oxygen species production and resistance to oxidative stress might be causally involved in the exceptional longevity exhibited by the ocean quahog Arctica islandica. We tested this hypothesis by comparing reactive oxygen sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb9b4a9fc469074e78fea0c69591c4a
https://doi.org/10.1093/gerona/glr044
https://doi.org/10.1093/gerona/glr044
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Autor:
Mondira Kundu, Rebecca A. Kohnz, Sara Gelino, David B. Shackelford, Malene Hansen, Maria M. Mihaylova, Debbie S. Vasquez, Daniel F. Egan, Dana M. Gwinn, Andrew Dillin, James A. J. Fitzpatrick, Aashish Joshi, Rebecca C. Taylor, William B. Mair, Benoit Viollet, John M. Asara, Reuben J. Shaw
Publikováno v:
Science. 331:456-461
Adenosine monophosphate-activated protein kinase (AMPK) is a conserved sensor of intracellular energy activated in response to low nutrient availability and environmental stress. In a screen for conserved substrates of AMPK, we identified ULK1 and UL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd0565c9531cd27438bf4cf52f7d7a6
https://doi.org/10.1126/science.1196371
https://doi.org/10.1126/science.1196371
Autor:
Orane Visvikis, Louis R. Lapierre, Chu-Chiao Chu, Malene Hansen, Binnan Ong, Jessica T. Chang, Sara Gelino, Philip R. McQuary, C. Daniel De Magalhaes Filho, Andrew Dillin, Andrew Davis, Javier E. Irazoqui
Publikováno v:
Nature Communications. 4
Autophagy is a cellular recycling process that has an important anti-aging role, but the underlying molecular mechanism is not well understood. The mammalian transcription factor EB (TFEB) was recently shown to regulate multiple genes in the autophag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a4030da4bb962015fc743a8354a9e6
https://doi.org/10.1038/ncomms3267
https://doi.org/10.1038/ncomms3267