Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sara Garcia-Rates"'
Autor:
Sanskar Ranglani, Sibah Hasan, Kashif Mahfooz, Jack Gordon, Sara Garcia-Rates, Susan Greenfield
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115498- (2023)
T14, a 14mer peptide derived from the C-terminus of acetylcholinesterase (AChE) is a signalling molecule that could drive neurodegeneration via the alpha 7 nicotinic acetylcholine receptor. Its levels increase as Alzheimer’s pathology progresses; h
Externí odkaz:
https://doaj.org/article/b4d8de3c9a6c475ba3900e4df4e98f2a
Autor:
Sanskar Ranglani, Anna Ashton, Kashif Mahfooz, Joanna Komorowska, Alexandru Graur, Nadine Kabbani, Sara Garcia-Rates, Susan Greenfield
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9961 (2023)
T14 modulates calcium influx via the α-7 nicotinic acetylcholine receptor to regulate cell growth. Inappropriate triggering of this process has been implicated in Alzheimer’s disease (AD) and cancer, whereas T14 blockade has proven therapeutic pot
Externí odkaz:
https://doaj.org/article/f95c889a532e4c2daa64d25873164f90
Autor:
Susan Adele Greenfield, Giovanni Ferrati, Clive W. Coen, Auguste Vadisiute, Zoltan Molnár, Sara Garcia-Rates, Sally Frautschy, Gregory M. Cole
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13119 (2022)
The substantia nigra is generally considered to show significant cell loss not only in Parkinson’s but also in Alzheimer’s disease, conditions that share several neuropathological traits. An interesting feature of this nucleus is that the pars co
Externí odkaz:
https://doaj.org/article/ad5a244148ea4760b25e50d36404d206
Autor:
Greenfield, Sanskar Ranglani, Anna Ashton, Kashif Mahfooz, Joanna Komorowska, Alexandru Graur, Nadine Kabbani, Sara Garcia-Rates, Susan
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 9961
T14 modulates calcium influx via the α-7 nicotinic acetylcholine receptor to regulate cell growth. Inappropriate triggering of this process has been implicated in Alzheimer’s disease (AD) and cancer, whereas T14 blockade has proven therapeutic pot
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114120- (2023)
A 14mer peptide, T14, is a possible signaling molecule driving neurodegeneration. Its levels are doubled in the Alzheimer brain, but its effects can be blocked at the target alpha-7 receptor by a cyclised variant, ‘NBP14′, which has beneficial ef
Externí odkaz:
https://doaj.org/article/d469175d583f425f9cf710d32076c817
Autor:
Susan A. Greenfield, Gregory M. Cole, Clive W. Coen, Sally Frautschy, Ram P. Singh, Marisa Mekkittikul, Sara Garcia‐Ratés, Paul Morrill, Owen Hollings, Matt Passmore, Sibah Hasan, Nikisha Carty, Silvia Bison, Laura Piccoli, Renzo Carletti, Stephano Tacconi, Anna Chalidou, Matthew Pedercini, Tim Kroecher, Hubert Astner, Philip A. Gerrard
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction The neuronal mechanism driving Alzheimer's disease (AD) is incompletely understood. Methods Immunohistochemistry, pharmacology, biochemistry, and behavioral testing are employed in two pathological contexts—AD and a transgenic
Externí odkaz:
https://doaj.org/article/07684a389acc417a9545fbf1b57c644f
Publikováno v:
Pharmaceuticals, Vol 4, Iss 6, Pp 822-847 (2011)
Amphetamine derivatives such as methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) are widely abused drugs in a recreational context. This has led to concern because of the evidence that they are neurotoxic in animal m
Externí odkaz:
https://doaj.org/article/3b426082c641464b9ca716830e6d541c
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54864 (2013)
BACKGROUND: β-amyloid is regarded as a significant factor in Alzheimer's disease: but inefficient therapies based on this rationale suggests that additional signalling molecules or intermediary mechanisms must be involved in the actual initiation of
Externí odkaz:
https://doaj.org/article/bd52e6d5758c4a9e9e4dfd10f197cecf