Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sara Garcia-Ratés"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114120- (2023)
A 14mer peptide, T14, is a possible signaling molecule driving neurodegeneration. Its levels are doubled in the Alzheimer brain, but its effects can be blocked at the target alpha-7 receptor by a cyclised variant, ‘NBP14′, which has beneficial ef
Externí odkaz:
https://doaj.org/article/d469175d583f425f9cf710d32076c817
Autor:
Susan A. Greenfield, Gregory M. Cole, Clive W. Coen, Sally Frautschy, Ram P. Singh, Marisa Mekkittikul, Sara Garcia‐Ratés, Paul Morrill, Owen Hollings, Matt Passmore, Sibah Hasan, Nikisha Carty, Silvia Bison, Laura Piccoli, Renzo Carletti, Stephano Tacconi, Anna Chalidou, Matthew Pedercini, Tim Kroecher, Hubert Astner, Philip A. Gerrard
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction The neuronal mechanism driving Alzheimer's disease (AD) is incompletely understood. Methods Immunohistochemistry, pharmacology, biochemistry, and behavioral testing are employed in two pathological contexts—AD and a transgenic
Externí odkaz:
https://doaj.org/article/07684a389acc417a9545fbf1b57c644f
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 158
A 14mer peptide, T14, is a possible signaling molecule driving neurodegeneration. Its levels are doubled in the Alzheimer brain, but its effects can be blocked at the target alpha-7 receptor by a cyclised variant, 'NBP14', which has beneficial effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955085086f5e481e37bb91da8b991a6b
https://pubmed.ncbi.nlm.nih.gov/36521245
https://pubmed.ncbi.nlm.nih.gov/36521245
Autor:
Sara Garcia-Ratés, Susan Greenfield
Publikováno v:
The international journal of biochemistrycell biology. 149
Here we review the idea that Alzheimer's disease (AD) results from aberrant activation of a normal developmental mechanism. This process operates in primarily vulnerable, subcortical nuclei with a distinguishing embryological provenance: the basal ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8898a2690b437ec2e7a8e0b2e9077f77
https://pubmed.ncbi.nlm.nih.gov/35781081
https://pubmed.ncbi.nlm.nih.gov/35781081
Publikováno v:
Pharmaceuticals, Vol 4, Iss 6, Pp 822-847 (2011)
Amphetamine derivatives such as methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) are widely abused drugs in a recreational context. This has led to concern because of the evidence that they are neurotoxic in animal m
Externí odkaz:
https://doaj.org/article/3b426082c641464b9ca716830e6d541c
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54864 (2013)
BACKGROUND: β-amyloid is regarded as a significant factor in Alzheimer's disease: but inefficient therapies based on this rationale suggests that additional signalling molecules or intermediary mechanisms must be involved in the actual initiation of
Externí odkaz:
https://doaj.org/article/bd52e6d5758c4a9e9e4dfd10f197cecf
Autor:
Christopher Fegan, Chris Pepper, Henry Tu, Paul Morrill, Susan A. Greenfield, Sara Garcia-Ratés
Publikováno v:
Oncotarget
A 14mer peptide (T14) derived from the C-terminus of acetylcholinesterase\ud (AChE) selectively activates metastatic breast cancer cells via the alpha-7 nicotinic\ud receptor (α7 nAChR). This naturally occurring peptide is also present in brain, is\
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050fa5061aeecd663c5c4e12df1086ad
http://sro.sussex.ac.uk/id/eprint/72718/2/14545-216181-1-PB.pdf
http://sro.sussex.ac.uk/id/eprint/72718/2/14545-216181-1-PB.pdf
Autor:
Sara Garcia-Ratés, Susan A. Greenfield
Publikováno v:
Oncotarget
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeec80010a36682267fb75a4d4e71fbd
http://europepmc.org/articles/PMC5410222
http://europepmc.org/articles/PMC5410222
Publikováno v:
Toxicology and Applied Pharmacology. 223:195-205
Previous work from our group indicated that alpha7 nicotinic acetylcholine receptors (alpha7 nAChR) potentially play a role in methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA) neurotoxicity. The aims of the present study were two-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5bb93be86cf34884b6bf2c97d45cbee
https://doi.org/10.1016/j.taap.2007.05.015
https://doi.org/10.1016/j.taap.2007.05.015
Autor:
Antoine-Scott Badin, Susan A. Greenfield, Catherine Heffner, Clive W. Coen, Cristina Tormo-Garcia, Paul Morrill, Henry Tu, Sara Garcia-Ratés, Gwenael Pottiez
Publikováno v:
Neuropharmacology. 105
The primary cause of Alzheimer's disease is unlikely to be the much studied markers amyloid beta or tau. Their widespread distribution throughout the brain does not account for the specific identity and deep subcortical location of the primarily vuln
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a399233199fcadf4187a0142e99e139e
https://pubmed.ncbi.nlm.nih.gov/26867503
https://pubmed.ncbi.nlm.nih.gov/26867503