Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sara Gallini"'
Autor:
Simone Culurgioni, Sara Mari, Paola Bonetti, Sara Gallini, Greta Bonetto, Martha Brennich, Adam Round, Francesco Nicassio, Marina Mapelli
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
During asymmetric divisions fate determinants and niche contacts segregate unequally between daughter cells, but the mechanism is unclear. Here the authors show that Insc:LGN tetramers promote assembly of Par3-Insc-LGN-GαiGDP complexes and asymmetri
Externí odkaz:
https://doaj.org/article/e44593885a164953a1d0c6b9547809f9
Tissue regeneration and maintenance rely on coordinated stem cell behaviors. This orchestration can be impaired by oncogenic mutations leading to tissue architecture disruption and ultimately cancer formation. However, it is still largely unclear how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::908e5f0a1c6a8e4c5d0acf738521a872
https://doi.org/10.1101/2022.09.14.507992
https://doi.org/10.1101/2022.09.14.507992
Autor:
Sara Gallini, Nur-Taz Rahman, Karl Annusver, David G. Gonzalez, Sangwon Yun, Catherine Matte-Martone, Tianchi Xin, Elizabeth Lathrop, Kathleen C. Suozzi, Maria Kasper, Valentina Greco
Healthy skin is a tapestry of wild-type and mutant clones. Although injury can cooperate with Ras mutations to promote tumorigenesis, the consequences in genetically mosaic skin are unknown. Here, we show that wild-type cells prevent oncogenic Ras-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5b03a2501c47f3bebc5c3a99a42e44a
https://doi.org/10.1101/2022.01.05.475078
https://doi.org/10.1101/2022.01.05.475078
Autor:
Valentina Greco, Sara Gallini, Edward Marsh, Tianchi Xin, Kathleen C. Suozzi, Nathan R. Fons, Elizabeth A. Lathrop, Don X. Nguyen, Cristiana M. Pineda, David G. Gonzalez, Slobodan Beronja, Jonathan D. Boucher, Karen Tai, Catherine Matte-Martone
Publikováno v:
Journal of Cell Biology. 218:3212-3222
Mutations associated with tumor development in certain tissues can be nontumorigenic in others, yet the mechanisms underlying these different outcomes remains poorly understood. To address this, we targeted an activating Hras mutation to hair follicl
Publikováno v:
Nature Structural & Molecular Biology. 23:155-163
Polarized epithelia form by oriented cell divisions in which the mitotic spindle aligns parallel to the epithelial plane. To orient the mitotic spindle, cortical cues trigger the recruitment of NuMA-dynein-based motors, which pull on astral microtubu
Autor:
Sara Gallini, Valentina Greco
Publikováno v:
Molecular Cancer Research. 18:A16-A16
Cancer development depends on the capacity of malignant cells to boost growth-promoting signals and restrain growth-inhibiting mechanisms, thus resulting in unbalanced homeostasis. Among growth-promoting mechanisms, sustained proliferation has been d
Autor:
Greta Bonetto, Sara Mari, Paola Bonetti, Simone Culurgioni, Francesco Nicassio, Sara Gallini, Martha Brennich, Marina Mapelli, Adam Round
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
'Nature Communications ', vol: 9, pages: 1025-1-1025-13 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
'Nature Communications ', vol: 9, pages: 1025-1-1025-13 (2018)
Asymmetric cell divisions balance stem cell proliferation and differentiation to sustain tissue morphogenesis and homeostasis. During asymmetric divisions, fate determinants and niche contacts segregate unequally between daughters, but little is know
Autor:
Giulia Guarguaglini, Laura Pirovano, Italia Anna Asteriti, Manuel Carminati, Fabiola De Mattia, Emanuele Martini, Amanda Oldani, Sara Gallini, Marina Mapelli
Publikováno v:
Current biology 26 (2016): 458–469. doi:10.1016/j.cub.2015.12.051
info:cnr-pdr/source/autori:Gallini, Sara; Carminati, Manuel; De Mattia, Fabiola; Pirovano, Laura; Martini, Emanuele; Oldani, Amanda; Asteriti, Italia Anna; Guarguaglini, Giulia; Mapelli, Marina/titolo:NuMA Phosphorylation by Aurora-A Orchestrates Spindle Orientation/doi:10.1016%2Fj.cub.2015.12.051/rivista:Current biology/anno:2016/pagina_da:458/pagina_a:469/intervallo_pagine:458–469/volume:26
info:cnr-pdr/source/autori:Gallini, Sara; Carminati, Manuel; De Mattia, Fabiola; Pirovano, Laura; Martini, Emanuele; Oldani, Amanda; Asteriti, Italia Anna; Guarguaglini, Giulia; Mapelli, Marina/titolo:NuMA Phosphorylation by Aurora-A Orchestrates Spindle Orientation/doi:10.1016%2Fj.cub.2015.12.051/rivista:Current biology/anno:2016/pagina_da:458/pagina_a:469/intervallo_pagine:458–469/volume:26
Spindle positioning is essential for tissue morphogenesis and homeostasis. The signaling network synchronizing spindle placement with mitotic progression relies on timely recruitment at the cell cortex of NuMA: LGN: Gai complexes, in which NuMA acts
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 70:C1057-C1057
Asymmetric cell divisions regulate the position and the fate choice of daughter cells, with impact on developmental programs and tissue homeostasis. The asymmetric outcome of a stem cell division relies on the coordination between cortical polarity a