Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sara G. Manore"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Breast cancer is the most commonly diagnosed cancer in women. Metastasis is the primary cause of mortality for breast cancer patients. Multiple mechanisms underlie breast cancer metastatic dissemination, including the interleukin-6 (IL-6)-mediated si
Externí odkaz:
https://doaj.org/article/d6087abb4d814e298db9c164d2c81690
Publikováno v:
Genes, Vol 13, Iss 11, p 2065 (2022)
Human epidermal growth factor receptor 2 (HER2) receptor tyrosine kinase is overexpressed in 20–30% of breast cancers and is associated with poor prognosis and worse overall patient survival. Most women with HER2-positive breast cancer receive neoa
Externí odkaz:
https://doaj.org/article/7cbb10e7437e4ff6b216976f9a2ee41e
Autor:
Angelina T. Regua, Noah R. Aguayo, Sara Abu Jalboush, Daniel L. Doheny, Sara G. Manore, Dongqin Zhu, Grace L. Wong, Austin Arrigo, Calvin J. Wagner, Yang Yu, Alexandra Thomas, Michael D. Chan, Jimmy Ruiz, Guangxu Jin, Roy Strowd, Peiqing Sun, Jiayuh Lin, Hui-Wen Lo
Publikováno v:
Cancers, Vol 13, Iss 10, p 2340 (2021)
JAK2–STAT3 and TrkA signaling pathways have been separately implicated in aggressive breast cancers; however, whether they are co-activated or undergo functional interaction has not been thoroughly investigated. Herein we report, for the first time
Externí odkaz:
https://doaj.org/article/94096733bb194533b356089812ff67d7
Publikováno v:
Cells, Vol 9, Iss 9, p 2114 (2020)
The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a consequence of improper control, aberrant HH signaling results in tumorigenesis and supports aggressive phenotypes of human cancers, such as neoplastic transfo
Externí odkaz:
https://doaj.org/article/93aa582e76204237a4d62b80584a8fb4
Publikováno v:
Seminars in Cancer Biology. 86:84-106
Breast cancer is the most commonly diagnosed cancer and second-leading cause of cancer deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic resistance contributing to tumor relapse. Through activating genes important f
Autor:
Sherona R. Sirkisoon, Grace L. Wong, Noah R. Aguayo, Daniel L. Doheny, Dongqin Zhu, Angelina T. Regua, Austin Arrigo, Sara G. Manore, Calvin Wagner, Alexandra Thomas, Ravi Singh, Fei Xing, Guangxu Jin, Kounosuke Watabe, Hui-Wen Lo
Publikováno v:
Cancer letters. 540
Mechanisms underlying breast cancer brain metastasis (BCBM) are still unclear. In this study, we observed that extracellular vesicles (EVs) secreted from breast cancer cells with increased expression of tGLI1, a BCBM-promoting transcription factor, s
Autor:
Jason C. Hurlbert, Morgan T. Turnow, Mikala R. Smith, William E. Cotham, Angel A. Castro, Caylie A. McGlade, Kevin M. Mays, Louise M. Hardwick, Tiffany S. Dwyer, Kendarius J. Butler, Sara G. Manore, Lisa N. Hair, Michael D. Walla, Melody C. Iacino, T. Christian Grattan, Matthew R. Wilson, Stephanie R. Woodson, Erin W. Parker
Publikováno v:
Bioorg Med Chem Lett
The sphingomyelin pathway is important in cell regulation and determining cellular fate. Inhibition of sphingosine kinase isoform 1 (SK1) within this pathway, leads to a buildup of sphingosine and ceramide, two molecules directly linked to cell apopt
Autor:
Sara G. Manore, Daniel L. Doheny, Dongqin Zhu, Grace L. Wong, Angelina T. Regua, Austin Arrigo, Calvin J. Wagner, Mariana Najjar, Hui-Wen Lo
Publikováno v:
Cancer Research. 82:92-92
Breast cancer is the most frequently diagnosed cancer and second leading cause of cancer-related deaths in women; 30% of primary breast cancer cases will develop distant metastases. The majority (90%) of breast cancer-related deaths are due to distan
Autor:
Angelina T. Regua, Dongqin Zhu, Daniel L. Doheny, Grace L. Wong, Sara G. Manore, Calvin J. Wagner, Austin Arrigo, Mariana Najjar, Hui-Wen Lo
Publikováno v:
Cancer Research. 82:1039-1039
Breast cancer is the most commonly diagnosed cancer in American women and accounts for ~15% of cancer-related deaths. Despite the current standard of care, metastatic HER2-enriched breast cancer and triple-negative breast cancer remain difficult to t
Autor:
Grace L. Wong, Sherona R. Sirkisoon, Noah R. Aguayo, Daniel L. Doheny, Dongqin Zhu, Angelina T. Regua, Austin Arrigo, Sara G. Manore, Calvin J. Wagner, Alexandra Thomas, Ravi Singh, Fei Xing, Guangxu Jin, Kounosuke Watabe, Hui-Wen Lo
Publikováno v:
Cancer Research. 82:2354-2354
Breast cancer is the most frequently diagnosed cancer, and second most common source of brain metastasis in women. Despite recent advances in detection and therapeutics, patients with breast cancer brain metastases (BCBM) survive only 6-18 months aft