Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma

Autor: Sara G. Danielli, Yun Wei, Michael A. Dyer, Elizabeth Stewart, Heather Sheppard, Marco Wachtel, Beat W. Schäfer, Anand G. Patel, David M. Langenau

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Rhabdomyosarcoma (RMS) is a pediatric tumor that resembles undifferentiated muscle cells; yet the extent to which cell state heterogeneity is shared with human development has not been described. Using single-cell/nucleus RNA sequencing from

Externí odkaz: https://doaj.org/article/e29faed2ad884c858ba654d0b6fb5c27

Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance

Autor: Sara G. Danielli, Ermelinda Porpiglia, Andrea J. De Micheli, Natalia Navarro, Michael J. Zellinger, Ingrid Bechtold, Samanta Kisele, Larissa Volken, Joana G. Marques, Stephanie Kasper, Peter K. Bode, Anton G. Henssen, Dennis Gürgen, Olivier Delattre, Didier Surdez, Josep Roma, Peter Bühlmann, Helen M. Blau, Marco Wachtel, Beat W. Schäfer

Publikováno v: Science Advances, 9 (6)
Danielli, S G, Porpiglia, E, De Micheli, A J, Navarro, N, Zellinger, M J, Bechtold, I, Kisele, S, Volken, L, Marques, J G, Kasper, S, Bode, P K, Henssen, A G, Gürgen, D, Delattre, O, Surdez, D, Roma, J, Bühlmann, P, Blau, H M, Wachtel, M & Schäfer, B W 2023, ' Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance ', Science Advances, vol. 9, no. 6, eade9238 . https://doi.org/10.1126/sciadv.ade9238

Rhabdomyosarcoma (RMS) is a group of pediatric cancers with features of developing skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest remain elusive. Here, we combined single-cell RNA sequencing, mass cytometry, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4a878ea2cde7eec5bf8ac9c8637212
https://hdl.handle.net/20.500.11850/598915

Genomic and Epigenetic Changes Drive Aberrant Skeletal Muscle Differentiation in Rhabdomyosarcoma

Autor: Silvia Pomella, Sara G. Danielli, Rita Alaggio, Willemijn B. Breunis, Ebrahem Hamed, Joanna Selfe, Marco Wachtel, Zoe S. Walters, Beat W. Schäfer, Rossella Rota, Janet M. Shipley, Simone Hettmer

Publikováno v: Cancers. 15:2823

Rhabdomyosarcoma (RMS), the most common soft-tissue sarcoma in children and adolescents, represents an aberrant form of skeletal muscle differentiation. Both skeletal muscle development, as well as regeneration of adult skeletal muscle are governed b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1753d00911d8ddc89dd38ec357bb583
https://doi.org/10.3390/cancers15102823

Abstract 1679: Single-cell profiling reveals a conserved myogenic hierarchy in pediatric rhabdomyosarcomas amenable to differentiation therapy

Autor: Sara G. Danielli, Ermelinda Porpiglia, Andrea J. De Micheli, Ingrid Bechtold, Joana G. Marques, Stephanie Kasper, Helen M. Blau, Marco Wachtel, Beat W. Schäfer

Publikováno v: Cancer Research. 82:1679-1679

Rhabdomyosarcoma (RMS) is a highly aggressive pediatric soft tissue cancer, associated with the skeletal muscle lineage. Despite undoubted expression of key myogenic regulatory factors, RMS cells are blocked in a proliferative state and do not comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7274c0737bd35631958d1ac4c77d181
https://doi.org/10.1158/1538-7445.am2022-1679

Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma.

Autor: Danielli, Sara G., Wei, Yun, Dyer, Michael A., Stewart, Elizabeth, Sheppard, Heather, Wachtel, Marco, Schäfer, Beat W., Patel, Anand G., Langenau, David M.

Publikováno v: Nature Communications; 7/26/2024, Vol. 15 Issue 1, p1-14, 14p