Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sara Farrah Heuss"'
Autor:
Sara Farrah Heuss, Nadine Tarantino, Jacques Fantini, Delphine Ndiaye-Lobry, Julien Moretti, Alain Israël, Frédérique Logeat
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74392 (2013)
The activity of Notch ligands is tightly regulated by trafficking events occurring both before and after ligand-receptor interaction. In particular endocytosis and recycling have been shown to be required for full signaling activity of the ligands be
Externí odkaz:
https://doaj.org/article/a9c4afcbb02545b48b009a47e8d67df4
Autor:
Aasia Hussain, Nicolaos Palaskas, Yi Yu, Pedro R. Cutillas, Cihangir Yandim, Brian Schwartz, Florence I. Raynaud, Igor Vivanco, Pedro Casado, Eleftherios Kostaras, Angela Hayes, Glorianne Lazaro, Teresa Kaserer, Yuen-Li Chung, Sara Farrah Heuss
Publikováno v:
British Journal of Cancer
Background AKT, a critical effector of the phosphoinositide 3-kinase (PI3K) signalling cascade, is an intensely pursued therapeutic target in oncology. Two distinct classes of AKT inhibitors have been in clinical development, ATP-competitive and allo
Autor:
Carine Joffre, Paul A. Clarke, Chi Zhang, Sara Farrah Heuss, Alexia Hervieu, Stéphanie Kermorgant, Ludovic Ménard, Rachel Barrow-McGee
Publikováno v:
Sci Signal
Receptor tyrosine kinases (RTKs) are often overexpressed or mutated in cancers and drive tumor growth and metastasis. In the current model of RTK signaling, including that of the RTK MET, downstream phosphoinositide 3-kinase (PI3K) mediates both cell
Autor:
Vannary Meas-Yedid, Jean-Christophe Olivo-Marin, Sara Farrah Heuss, Julien Moretti, Neetu Gupta-Rossi, Alain Israël, Sara Ortica
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2011, 286 (21), pp.18720-30. ⟨10.1074/jbc.M110.190769⟩
Journal of Biological Chemistry, 2011, 286 (21), pp.18720-30. ⟨10.1074/jbc.M110.190769⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2011, 286 (21), pp.18720-30. ⟨10.1074/jbc.M110.190769⟩
Journal of Biological Chemistry, 2011, 286 (21), pp.18720-30. ⟨10.1074/jbc.M110.190769⟩
International audience; The Notch pathway is involved in cell-cell signaling during development and adulthood from invertebrates to higher eukaryotes. Activation of the Notch receptor by its ligands relies upon a multi-step processing. The extracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35fda7894afc66aa4168e8b17c77cd80
https://hal-pasteur.archives-ouvertes.fr/pasteur-00597362
https://hal-pasteur.archives-ouvertes.fr/pasteur-00597362
Autor:
Annette M.G. Dirac, Maria G. Masucci, Stefano Gastaldello, Sara Farrah Heuss, Alain Israël, Julien Moretti, René Bernards, Christel Brou, Patricia Chastagner
Publikováno v:
PLoS Biology
PLoS Biology, Vol 8, Iss 11, p e1000545 (2010)
PLoS Biology, Public Library of Science, 2010, 8 (11), pp.e1000545. ⟨10.1371/journal.pbio.1000545⟩
PLoS Biology, Vol 8, Iss 11, p e1000545 (2010)
PLoS Biology, Public Library of Science, 2010, 8 (11), pp.e1000545. ⟨10.1371/journal.pbio.1000545⟩
International audience; Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-secretase, giving ris
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2008, 105 (32), pp.11212-7. ⟨10.1073/pnas.0800695105⟩
Proceedings of the National Academy of Sciences of the United States of America, 2008, 105 (32), pp.11212-7. ⟨10.1073/pnas.0800695105⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2008, 105 (32), pp.11212-7. 〈10.1073/pnas.0800695105〉
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2008, 105 (32), pp.11212-7. ⟨10.1073/pnas.0800695105⟩
Proceedings of the National Academy of Sciences of the United States of America, 2008, 105 (32), pp.11212-7. ⟨10.1073/pnas.0800695105⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2008, 105 (32), pp.11212-7. 〈10.1073/pnas.0800695105〉
Genetic studies have shown that ubiquitination and endocytosis of the Drosophila ligand Delta in signal-sending cells are required for activation of Notch signaling, but how these events promote Notch activation remains poorly understood. Here, we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b1c1aababaa3e919ba744bdd5537bd
https://hal-pasteur.archives-ouvertes.fr/pasteur-00336966/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-00336966/document
Autor:
Alain Israël, Sara Farrah Heuss, Julien Moretti, Nadine Tarantino, Jacques Fantini, Delphine Ndiaye-Lobry, Frédérique Logeat
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74392 (2013)
PLoS ONE
PLoS ONE
The activity of Notch ligands is tightly regulated by trafficking events occurring both before and after ligand-receptor interaction. In particular endocytosis and recycling have been shown to be required for full signaling activity of the ligands be