Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds.

Autor: Tamer A Mansour, Katherine Lucot, Sara E Konopelski, Peter J Dickinson, Beverly K Sturges, Karen L Vernau, Shannon Choi, Joshua A Stern, Sara M Thomasy, Sophie Döring, Frank J M Verstraete, Eric G Johnson, Daniel York, Robert B Rebhun, Hsin-Yi Henry Ho, C Titus Brown, Danika L Bannasch

Publikováno v: PLoS Genetics, Vol 14, Iss 12, p e1007850 (2018)

Domestic dog breeds exhibit remarkable morphological variations that result from centuries of artificial selection and breeding. Identifying the genetic changes that contribute to these variations could provide critical insights into the molecular ba

Externí odkaz: https://doaj.org/article/af25a53b58fb43ba8553eb2e97acbc3a

Proteomic analysis identifies the E3 ubiquitin ligase Pdzrn3 as a regulatory target of Wnt5a-Ror signaling

Autor: Sara E. Konopelski Snavely, Michael W. Susman, Ryan C. Kunz, Jia Tan, Srisathya Srinivasan, Michael D. Cohen, Kyoko Okada, Helen Lamb, Shannon S. Choi, Edith P. Karuna, Michael K. Scales, Steven P. Gygi, Michael E. Greenberg, Hsin-Yi Henry Ho

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 25

Wnt5a-Ror signaling is a conserved pathway that regulates morphogenetic processes during vertebrate development [R. T. Moon et al, Development 119, 97-111 (1993); I. Oishi et al, Genes Cells 8, 645-654 (2003)], but its downstream signaling events rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685abbc48f6569680df2d03a3730d6a1
https://doi.org/10.1101/2020.06.22.163790

Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds

Autor: Hsin-Yi Henry Ho, Shannon S. Choi, Sara M Thomasy, Sophie Döring, Karen L. Vernau, Danika L. Bannasch, Sara E. Konopelski, Eric G. Johnson, Frank Verstraete, Joshua A. Stern, Peter J Dickinson, C. Titus Brown, Katherine L. Lucot, Tamer A. Mansour, Robert B. Rebhun, Beverly K. Sturges, Daniel York

Publikováno v: PLoS genetics, vol 14, iss 12
PLoS Genetics, Vol 14, Iss 12, p e1007850 (2018)
PLoS Genetics

Domestic dog breeds exhibit remarkable morphological variations that result from centuries of artificial selection and breeding. Identifying the genetic changes that contribute to these variations could provide critical insights into the molecular ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78a76a43d01dd6628840f87c51842c3
https://escholarship.org/uc/item/95k394sh

Regeneration of fat cells from myofibroblasts during wound healing

Autor: Mitchell A. Lazar, Priya H. Dedhia, Elsa Treffeisen, Ali Mortazavi, Ricardo Ramirez, Rabi Murad, Raul Ramos, Patrick Seale, Ji Won Oh, Christian F. Guerrero-Juarez, Daniel Metzger, Anne Wang, Rarinthip June Supapannachart, Xiaojie Wang, Stefan Offermanns, Tsai Ching Hsi, Hye Lim Lee, Arijh Elzein, Amanda Ramirez, Sarah E. Millar, Tai-Lan Tuan, Thomas Andl, Alan D. Widgerow, Arben Nace, Chae Ho Lim, Maksim V. Plikus, Bruce A. Hamilton, Sara E. Konopelski, Warren S. Pear, Mayumi Ito, Rana K. Gupta, Ying Zheng, Pierre Chambon, Mengle Shao, Yun Li, George Cotsarelis, Amy Guo

Publikováno v: Science
Science, 2017, 355 (6326), pp.748-752. ⟨10.1126/science.aai8792⟩
Science, American Association for the Advancement of Science, 2017, 355 (6326), pp.748-752. ⟨10.1126/science.aai8792⟩
Science (New York, N.Y.), vol 355, iss 6326

Hair follicles: Secret to prevent scars? Although some animals easily regenerate limbs and heal broken flesh, mammals are generally not so gifted. Wounding can leave scars, which are characterized by a lack of hair follicles and cutaneous fat. Plikus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69bd090c9365ab86d6b4e842c97da9b
https://cea.hal.science/cea-01896452