Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Sara E. Gombash"'
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Vitamin D insufficiency during childhood has been linked to the development of multiple sclerosis (MS), typically an adult-onset inflammatory demyelinating disease of the central nervous system (CNS). Since vitamin D was known to have immunoregulator
Externí odkaz:
https://doaj.org/article/3b9bfd14854b4788b6a4cfd4c63e648d
Publikováno v:
Frontiers in neurology. 13
Vitamin D insufficiency during childhood has been linked to the development of multiple sclerosis (MS), typically an adult-onset inflammatory demyelinating disease of the central nervous system (CNS). Since vitamin D was known to have immunoregulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d73e1c3c2fbf4fa752ec7af846c9307
https://pubmed.ncbi.nlm.nih.gov/35651353
https://pubmed.ncbi.nlm.nih.gov/35651353
Autor:
Kathy Steece-Collier, Jack W. Lipton, Fredric P. Manfredsson, Christopher J. Kemp, Megan F. Duffy, Nicole K. Polinski, D. Luke Fischer, Timothy J. Collier, Sara E. Gombash, Caryl E. Sortwell, Allyson Cole-Strauss, Daniel J. Buhlinger
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Scientific Reports
Scientific Reports
Subthalamic nucleus deep brain stimulation (STN DBS) protects dopaminergic neurons of the substantia nigra pars compacta (SNpc) against 6-OHDA and MPTP. We evaluated STN DBS in a parkinsonian model that displays α-synuclein pathology using unilatera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd225ca7a0bdc4910d333439956e1f1
http://link.springer.com/article/10.1038/s41598-017-16690-x
http://link.springer.com/article/10.1038/s41598-017-16690-x
Autor:
Arthur H.M. Burghes, Vicki L. McGovern, Jason D. Murray, Phillip G. Zaworski, Sara E. Gombash, Kevin D. Foust, Chitra C. Iyer, Paul M.L. Janssen
Publikováno v:
Human Molecular Genetics. 24:6160-6173
Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder characterized by loss of lower motor neurons. SMA is caused by deletion or mutation of the Survival Motor Neuron 1 (SMN1) gene and retention of the SMN2 gene. The loss of SMN1 results i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe373b989e01512c5e6d1fa16c47aa0
https://doi.org/10.1093/hmg/ddv332
https://doi.org/10.1093/hmg/ddv332
Autor:
Foust Kevin, Arthur H. M. Burghes, Anton J. Blatnik, Phillip G. Zaworski, Chitra C. Iyer, Vicki L. McGovern, Sara E. Gombash, W. David Arnold
Publikováno v:
Human Molecular Genetics. 24:5524-5541
Proximal spinal muscular atrophy (SMA) is the most frequent cause of hereditary infant mortality. SMA is an autosomal recessive neuromuscular disorder that results from the loss of the Survival Motor Neuron 1 (SMN1) gene and retention of the SMN2 gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa202b64230e5355320b5e6619b82b4
https://doi.org/10.1093/hmg/ddv283
https://doi.org/10.1093/hmg/ddv283
Autor:
Fredric P. Manfredsson, Christopher J. Kemp, Caryl E. Sortwell, Susan L. Wohlgenant, Allyson Cole-Strauss, Jack W. Lipton, Nicole K. Polinski, Nathan C. Kuhn, Kathy Steece-Collier, Sara E. Gombash, Nicholas M. Kanaan
Publikováno v:
Neurobiology of Aging. 36:1110-1120
Clinical trials are examining the efficacy of viral vector-mediated gene delivery for treating Parkinson's disease. Although viral vector strategies have been successful in preclinical studies, to date clinical trials have disappointed. This may be b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0ed1fe93418caca5c20b3ba9c442ea
https://doi.org/10.1016/j.neurobiolaging.2014.07.047
https://doi.org/10.1016/j.neurobiolaging.2014.07.047
Autor:
Susan L. Wohlgenant, Timothy J. Collier, Fredric P. Manfredsson, D L Fischer, Christopher J. Kemp, Sara E. Gombash, Sheila M. Fleming, Caryl E. Sortwell, N M Kuhn, Ronald J. Mandel
Publikováno v:
Gene Therapy. 21:682-693
Intrastriatal injection of recombinant adeno-associated viral vector serotype 2/1 (rAAV2/1) to overexpress the neurotrophic factor pleiotrophin (PTN) provides neuroprotection for tyrosine hydroxylase immunoreactive (THir) neurons in the substantia ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf63b6f0403364a561255257039b2db
https://doi.org/10.1038/gt.2014.42
https://doi.org/10.1038/gt.2014.42
Autor:
Christopher J. Kemp, D. Luke Fischer, Caryl E. Sortwell, Fredric P. Manfredsson, Sara E. Gombash, Nicole K. Polinski, Megan F. Duffy
Publikováno v:
Gene Therapy for Neurological Disorders ISBN: 9781493932702
Gene therapy methods are increasingly used to model Parkinson's disease (PD) in animals in an effort to test experimental therapeutics within a more relevant context to disease pathophysiology and neuropathology. We have detailed several criteria tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5214f7b44709ca74b591f19a07eb2396
https://doi.org/10.1007/978-1-4939-3271-9_26
https://doi.org/10.1007/978-1-4939-3271-9_26
Autor:
Kevin D. Foust, Sara E. Gombash
Publikováno v:
Gene Therapy for Neurological Disorders ISBN: 9781493932702
Systemic gene delivery is useful for modeling and treatment of a body-wide disease. Recently, it has been shown that certain agents, when delivered systemically, can efficiently target the central nervous system. This technique has been used to model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f838cb17df8a5f142109c10f15406d8
https://doi.org/10.1007/978-1-4939-3271-9_16
https://doi.org/10.1007/978-1-4939-3271-9_16
Autor:
Susan L. Wohlgenant, Caryl E. Sortwell, Lalitha Madhavan, Timothy J. Collier, Valerie Thompson, Allyson Cole-Strauss, Fredric P. Manfredsson, Ronald J. Mandel, Kathy Steece-Collier, Jack W. Lipton, Brian T. Terpstra, Anne L. Spieles-Engemann, Sara E. Gombash, Brian F. Daley
Publikováno v:
Molecular Therapy. 20:544-554
Neurotrophic factors are integrally involved in the development of the nigrostriatal system and in combination with gene therapy, possess great therapeutic potential for Parkinson's disease (PD). Pleiotrophin (PTN) is involved in the development, mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa234f21e6f51cc5a4b6067355a4b88
https://doi.org/10.1038/mt.2011.216
https://doi.org/10.1038/mt.2011.216