Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sara E. Billings"'
Autor:
Tian Wang, Angela H. Ling, Sara E. Billings, Davood K. Hosseini, Yona Vaisbuch, Grace S. Kim, Patrick J. Atkinson, Zahra N. Sayyid, Ksenia A. Aaron, Dhananjay Wagh, Nicole Pham, Mirko Scheibinger, Ruiqi Zhou, Akira Ishiyama, Lindsay S. Moore, Peter Santa Maria, Nikolas H. Blevins, Robert K. Jackler, Jennifer C. Alyono, John Kveton, Dhasakumar Navaratnam, Stefan Heller, Ivan A. Lopez, Nicolas Grillet, Taha A. Jan, Alan G. Cheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mammalian inner ear hair cell loss leads to permanent hearing and balance dysfunction. In contrast to the cochlea, vestibular hair cells of the murine utricle have some regenerative capacity. Whether human utricular hair cells regenerate in
Externí odkaz:
https://doaj.org/article/bbd2c632a6e24a05853cb5f0c56c9d00
Selection of viral capsids and promoters affects the efficacy of rescue of Tmprss3-deficient cochlea
Autor:
Ksenia A. Aaron, Katja Pekrun, Patrick J. Atkinson, Sara E. Billings, Julia M. Abitbol, Ina A. Lee, Yasmin Eltawil, Yuan-Siao Chen, Wuxing Dong, Rick F. Nelson, Mark A. Kay, Alan G. Cheng
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 413-428 (2023)
Adeno-associated virus (AAV)-mediated gene transfer has shown promise in rescuing mouse models of genetic hearing loss, but how viral capsid and promoter selection affects efficacy is poorly characterized. Here, we tested combinations of AAVs and pro
Externí odkaz:
https://doaj.org/article/12dd1baf9a7e41769ec3b2c66b940104
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The G protein-coupled receptor (GPR) family critically regulates development and homeostasis of multiple organs. As a member of the GPR adhesion family, Gpr125 (Adgra3) modulates Wnt/PCP signaling and convergent extension in developing zebrafish, but
Externí odkaz:
https://doaj.org/article/2626c18907ea46dfb7ce734b04475a39
Autor:
Tian Wang, Angela H. Ling, Sara E. Billings, Davood K. Hosseini, Yona Vaisbuch, Grace S. Kim, Patrick J. Atkinson, Zahra N. Sayyid, Ksenia A. Aaron, Dhananjay Wagh, Nicole Pham, Mirko Scheibinger, Akira Ishiyama, Peter Santa Maria, Nikolas H. Blevins, Robert K. Jackler, Stefan Heller, Ivan A. Lopez, Nicolas Grillet, Taha A. Jan, Alan G. Cheng
Mammalian inner ear hair cell loss leads to permanent hearing and balance dysfunction. In contrast to the cochlea, vestibular hair cells of the murine utricle have some regenerative capacity. Whether human utricular hair cells regenerate remains unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d51fc5ccbf2422a031a62c457d223be
https://doi.org/10.1101/2022.10.29.514378
https://doi.org/10.1101/2022.10.29.514378
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
The G protein-coupled receptor (GPR) family critically regulates development and homeostasis of multiple organs. As a member of the GPR adhesion family, Gpr125 (Adgra3) modulates Wnt/PCP signaling and convergent extension in developing zebrafish, but
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
article-version (VoR) Version of Record
During embryonic development, the otic epithelium and surrounding periotic mesenchymal cells originate from distinct lineages and coordinate to form the mammalian cochlea. Epithelial sensory precursors within the cochlear duct first undergo terminal
Publikováno v:
NeuroReport. 23:49-54
The cytoskeletal matrix of the active zone and synaptic voltage-dependent calcium channels (VDCCs) are both necessary components for the organization and regulation of synaptic vesicle release. In this study, we report a novel interaction between the
Autor:
Douglas Forrest, Xiangming Li, David S. Sharlin, Philine Wangemann, Hyoung-Mi Kim, Daniel C. Marcus, Ruchira Singh, Sara E. Billings, Peying Fong, Kazuhiro Nakaya
Publikováno v:
American Journal of Physiology-Renal Physiology
Mutations of SLC26A4 cause an enlarged vestibular aqueduct, nonsyndromic deafness, and deafness as part of Pendred syndrome. SLC26A4 encodes pendrin, an anion exchanger located in the cochlea, thyroid, and kidney. The goal of the present study was to
Autor:
Naomi E. Butler Tjaden, Xiao-Yan Pang, Maureen A. Kane, Paul A. Trainor, Alexander R. Moise, Keely Pierzchalski, Sara E. Billings
Publikováno v:
The FASEB Journal. 28
Background: The levels of the signaling molecule all-trans-retinoic acid (ATRA) are tightly controlled at the level of enzymes involved in its synthesis and degradation. Previous studies have implicated the retinaldehyde reductase DHRS3 in establishi
Autor:
Alexander R. Moise, Sara E. Billings, Naomi E. Butler Tjaden, Maureen A. Kane, Keely Pierzchalski, Paul A. Trainor, Xiao-Yan Pang
Oxidation of retinol via retinaldehyde results in the formation of the essential morphogen all-trans-retinoic acid (ATRA). Previous studies have identified critical roles in the regulation of embryonic ATRA levels for retinol, retinaldehyde, and ATRA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347605eef5060d9e14fbcab2264f7d3f
https://europepmc.org/articles/PMC3834788/
https://europepmc.org/articles/PMC3834788/