MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid haemorrhage in rats.

Autor: Simon T Christensen, Sara E Johansson, Aneta Radziwon-Balicka, Karin Warfvinge, Kristian A Haanes, Lars Edvinsson

Publikováno v: PLoS ONE, Vol 14, Iss 4, p e0215398 (2019)

Vascular pathophysiological changes after haemorrhagic stroke, such as phenotypic modulation of the cerebral arteries and cerebral vasospasms, are associated with delayed cerebral ischemia (DCI) and poor outcome. The only currently approved drug trea

Externí odkaz: https://doaj.org/article/20ca4763d19b4e399e65be7a12aab0d6

Alterations in the Cerebral Microvascular Proteome Expression Profile After Transient Global Cerebral Ischemia in Rat

Autor: Alistair V G Edwards, Gro Klitgaard Povlsen, Aneta Radziwon-Balicka, Martin R. Larsen, Sara E Johansson, Lars Edvinsson, Stine Spray

Publikováno v: Spray, S, Johansson, S E, Edwards, A V G, Larsen, M R, Radziwon-Balicka, A, Povlsen, G K & Edvinsson, L 2017, ' Alterations in the Cerebral Microvascular Proteome Expression Profile After Transient Global Cerebral Ischemia in Rat ', Journal of Molecular Neuroscience, vol. 61, no. 3, pp. 396–411 . https://doi.org/10.1007/s12031-016-0875-8

This study aimed at obtaining an in-depth mapping of expressional changes of the cerebral microvasculature after transient global cerebral ischemia (GCI) and the impact on these GCI-induced expressional changes of post-GCI treatment with a mitogen-ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2084d96a543585950c6b29f38bee40fc
https://doi.org/10.1007/s12031-016-0875-8