Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase

Autor: Nyam Osor Chimge, Baruch Frenkel, Fan Li, Younho Choi, Chengyu Liang, Yongfei Yang, Sara Dolatshahi Pirooz, Tian Zhang, Qiaoxiu Wang, Sally B Chen, Zengqiang Yuan, Douglas O’Connell, Mi Jeong Kwak, Byung-Ha Oh, Shanshan He, Yong Heui Jeon, Grace M. Aldrovandi

Publikováno v: Molecular cell, vol 62, iss 4
Yang, Y; He, S; Wang, Q; Li, F; Kwak, M-J; Chen, S; et al.(2016). Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. MOLECULAR CELL, 62(4), 507-519. doi: 10.1016/j.molcel.2016.04.014. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1rf7p1n7

Ultraviolet (UV)-induced DNA damage, a major risk factor for skin cancers, is primarily repaired by nucleotide excision repair (NER). UV-radiation Resistance Associated Gene (UVRAG) is a tumor suppressor involved in autophagy. It was initially isolat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cc85898948fc01c2469c04f8814c38
https://pubmed.ncbi.nlm.nih.gov/27203177

Viruses customize autophagy protein for efficient viral entry

Autor: Shanshan He, Yongfei Yang, Payam Khalilzadeh, Sara Dolatshahi Pirooz, Chengyu Liang, Douglas O’Connell

Publikováno v: Autophagy. 10(7)

While the cell imposes multiple barriers to virus entry, enveloped viruses are remarkably still able to gain entry to their cellular hosts by hitchhiking and remodeling the endomembrane system to traffic within, and eventually escape from, endosomal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39c57a9b93f95330778455a6786e201
https://pubmed.ncbi.nlm.nih.gov/24905575

A dual role for UVRAG in maintaining chromosomal stability independent of autophagy

Autor: Shunhua Yang, Jeremy M. Stark, Chengyu Liang, Soohwan Oh, Zhen Zhao, Duojiao Ni, Joo-Hyung Lee, Vincenzo Costanzo, Sara Dolatshahi Pirooz, Irene Ghozalli, June-Yong Lee, Dapeng Li

SummaryAutophagy defects have recently been associated with chromosomal instability, a hallmark of human cancer. However, the functional specificity and mechanism of action of autophagy-related factors in genome stability remain elusive. Here we repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1879a90318d6967fe648d5b3d723ff0
http://hdl.handle.net/11588/502221

Measurement of γHV68 Infection in Mice

Autor: Zhen Zhao, Duojiao Ni, Sara Dolatshahi Pirooz, Joo-Hyung Lee, Chengyu Liang, Soohwan Oh

Publikováno v: Scopus-Elsevier

γ-Herpesviruses (γ-HVs) are notable for their ability to establish latent infections of lymphoid cells(1). The narrow host range of human γ-HVs, such as EBV and KSHV, has severely hindered detailed pathogenic studies. Murine γ-herpesvirus 68 (γH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0bd0dac810c1e2123f0766aa73a576
https://europepmc.org/articles/PMC3308616/

UVRAG

Autor: Binyun Ma, Duojiao Ni, Irene Ghozalli, Zhen Zhao, Chengyu Liang, Sara Dolatshahi Pirooz

Publikováno v: Autophagy. 8:1392-1393

UVRAG is a promoter of the autophagy pathway, and its deficiency may fuel the development of cancers. Intriguingly, our recent study has demonstrated that this protein also mediates the repair of damaged DNA and patrols centrosome stability, mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f2a26d3074ca16bbc610bb194a875f
https://doi.org/10.4161/auto.21035