Výsledky vyhledávání - "Sara Di Silvestre"

Akademický článek

Calcimimetic R-568 vasodilatory effect on mesenteric vascular beds from normotensive (WKY) and spontaneously hypertensive (SHR) rats. Potential involvement of vascular smooth muscle cells (vSMCs).

Autor: Natalia Di Pietro, Maria Assunta Potenza, Sara Di Silvestre, Francesco Addabbo, Nadia Di Pietrantonio, Pamela Di Tomo, Caterina Pipino, Domitilla Mandatori, Carola Palmerini, Paola Failli, Mario Bonomini, Monica Montagnani, Assunta Pandolfi

Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0202354 (2018)

The potential role of calcimimetics as vasculotropic agents has been suggested since the discovery that calcium sensing receptors (CaSRs) are expressed in cardiovascular tissues. However, whether this effect is CaSR-dependent or -independent is still

Externí odkaz: https://doaj.org/article/c83f53728d0f4a2092d20abd115d88c3

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Akademický článek

A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with insulin sensitivity.

Autor: Francesco Andreozzi, Ivan Presta, Gaia Chiara Mannino, Daniela Scarpelli, Sara Di Silvestre, Natalia Di Pietro, Elena Succurro, Angela Sciacqua, Assunta Pandolfi, Agostino Consoli, Marta Letizia Hribal, Francesco Perticone, Giorgio Sesti

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e36224 (2012)

BackgroundAsymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide synthase, which was associated with insulin resistance. Dimethylarginine dimethylaminohydrolase (DDAH) is the major determinant of plasma ADMA. Examin

Externí odkaz: https://doaj.org/article/83f380630062439381abc3f41de6531b

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Akademický článek

Calcimimetic R-568 and its enantiomer S-568 increase nitric oxide release in human endothelial cells.

Autor: Mario Bonomini, Annalisa Giardinelli, Caterina Morabito, Sara Di Silvestre, Moreno Di Cesare, Natalia Di Pietro, Vittorio Sirolli, Gloria Formoso, Luigi Amoroso, Maria Addolorata Mariggiò, Assunta Pandolfi

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e30682 (2012)

Calcimimetics, such as R-568, are thought to activate G protein-linked Ca(2+)-sensing receptor (CaSR) by allosterically increasing the affinity of the receptor for Ca(2+) allowing for efficient control of uremic hyperparathyroidism. Several recent st

Externí odkaz: https://doaj.org/article/6f8eeb94a4ae41a0aef6a5d5259dbd00

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Establishment and long-term culture of human cystic fibrosis endothelial cells

Autor: Federico Venuta, Sara Di Silvestre, Roberto Plebani, Marco Anile, Assunta Pandolfi, Felice Mucilli, Marco Marchisio, Paola Lanuti, Romina Tripaldi, Antonio Recchiuti, Marco Prioletta, Pasquale Simeone, Sara Patruno, Paola Del Porto, Mario R. Romano

Publikováno v: Laboratory Investigation. 97:1375-1384

Endothelial cell (EC) dysfunction has been reported in cystic fibrosis (CF) patients. Thus, the availability of CF EC is paramount to uncover mechanisms of endothelial dysfunction in CF. Using collagenase digestion, we isolated cells from small fragm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305d78204b1c8c06fb9ba160c0d72236
https://doi.org/10.1038/labinvest.2017.74

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Menaquinone‐4 enhances osteogenic potential of human amniotic fluid mesenchymal stem cells cultured in 2D and 3D dynamic culture systems

Autor: Sara Trevisani, Mariangela Ucci, Assunta Pandolfi, Marco Angelozzi, Caterina Pipino, Domitilla Mandatori, Roberta Piva, Letizia Penolazzi, Natalia Di Pietro, Sara Di Silvestre, Pamela Di Tomo

Publikováno v: Journal of Tissue Engineering and Regenerative Medicine. 12:447-459

Menaquinones, also known as Vitamin K2 family, regulate calcium homeostasis in a 'bone-vascular cross-talk' and recently received particular attention for their positive effect on bone formation. Given that the correlation between menaquinones and bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c0760d9deaeae5eeda55e31c2fae0d
https://doi.org/10.1002/term.2471

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Plasma from pre-pubertal obese children impairs insulin stimulated Nitric Oxide (NO) bioavailability in endothelial cells: Role of ER stress

Autor: Assunta Pandolfi, Sara Di Silvestre, Paola Lanuti, Giuseppina Bologna, Natalia Di Pietro, Francesco Chiarelli, Vincenzo Giuseppe Pio Cordone, Tommaso de Giorgis, Angelika Mohn, M. Loredana Marcovecchio

Publikováno v: Molecular and Cellular Endocrinology

Childhood obesity is commonly associated with early signs of endothelial dysfunction, characterized by impairment of insulin signaling and vascular Nitric Oxide (NO) availability. However, the underlying mechanisms remain to be established. Hence, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7922c9b7d8e84a65c2b2b11e915045
https://doi.org/10.1016/j.mce.2017.01.001

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Anti-inflammatory Role of Carotenoids in Endothelial Cells Derived from Umbilical Cord of Women Affected by Gestational Diabetes Mellitus

Autor: Paola Lanuti, Pamela Di Tomo, Caterina Pipino, Mariangela Ucci, Gloria Formoso, Federica Tritschler, Domitilla Mandatori, Vincenzo Giuseppe Pio Cordone, Assunta Pandolfi, Giuseppina Bologna, Natalia Di Pietro, Sara Di Silvestre

Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity

Diabetes is associated with vascular inflammation, endothelial dysfunction, and oxidative stress, promoting the development of cardiovascular diseases (CVD). Several studies showed that a carotenoid-rich diet is associated to a reduced cardiovascular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190a30129050cd9e46f962db88070368
https://doaj.org/article/0d51781d799d45fbaf74543fa9f88077

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Effect of peritoneal dialysis fluid containing osmo-metabolic agents on human endothelial cells

Autor: Natalia Di Pietro, Domitilla Mandatori, Vittorio Sirolli, Arduino Arduini, Sara Di Silvestre, Pamela Di Tomo, Francesco Chiarelli, Lorenzo Di Liberato, Assunta Pandolfi, Mario Bonomini, Cesare Indiveri

Publikováno v: Drug Design, Development and Therapy

Mario Bonomini,1,2 Sara Di Silvestre,3,4 Pamela Di Tomo,3,4 Natalia Di Pietro,2,4 Domitilla Mandatori,3,4 Lorenzo Di Liberato,1 Vittorio Sirolli,1,2 Francesco Chiarelli,2,4 Cesare Indiveri,5 Assunta Pandolfi,3,4 Arduino Arduini6 1Unit of Nephrology a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3928087378d12c2435907154da5b7135
https://doi.org/10.2147/dddt.s117078

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Nitric oxide synthetic pathway and cGMP levels are altered in red blood cells from end-stage renal disease patients

Autor: Assunta Pandolfi, Pamela Di Tomo, Elena Gazzano, Annalisa Giardinelli, Christina Panknin, Péter Ferdinandy, Vittorio Sirolli, Csaba Csonka, Mario Bonomini, Miriam M. Cortese-Krott, Chiara Riganti, Malte Kelm, Sara Di Silvestre, Natalia Di Pietro

Publikováno v: Molecular and Cellular Biochemistry. 417:155-167

Red blood cells (RBCs) enzymatically produce nitric oxide (NO) by a functional RBC-nitric oxide synthase (RBC-NOS). NO is a vascular key regulatory molecule. In RBCs its generation is complex and influenced by several factors, including insulin, acet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c4ee862b4bf3b098ce4ba47c0943e5
https://doi.org/10.1007/s11010-016-2723-0

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Human Mesenchymal Stem Cells Reendothelialize Porcine Heart Valve Scaffolds: Novel Perspectives in Heart Valve Tissue Engineering

Autor: Paola Lanuti, Francesco Serafini, Laura Pierdomenico, Pasquale Simeone, Giuseppina Bologna, Eva Ercolino, Sara Di Silvestre, Simone Guarnieri, Carlo Canosa, Gianna Gabriella Impicciatore, Stella Chiarini, Francesco Magnacca, Maria Addolorata Mariggiò, Assunta Pandolfi, Marco Marchisio, Gabriele Di Giammarco, Sebastiano Miscia

Publikováno v: BioResearch Open Access, Vol 4, Iss 1, Pp 288-297 (2015)
BioResearch Open Access

Heart valve diseases are usually treated by surgical intervention addressed for the replacement of the damaged valve with a biosynthetic or mechanical prosthesis. Although this approach guarantees a good quality of life for patients, it is not free f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f55eccff586df8675a43fc03ab79f4
https://doi.org/10.1089/biores.2015.0019

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