Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Sara Di Castro"'
1
Akademický článek
Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease
Autor: Speranza Rubattu, Sara Di Castro, Herbert Schulz, Aron M. Geurts, Maria Cotugno, Franca Bianchi, Henrike Maatz, Oliver Hummel, Samreen Falak, Rosita Stanzione, Simona Marchitti, Stefania Scarpino, Betti Giusti, Ada Kura, Gian Franco Gensini, Flora Peyvandi, Pier Mannuccio Mannucci, Maurizia Rasura, Sebastiano Sciarretta, Melinda R. Dwinell, Norbert Hubner, Massimo Volpe
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 2 (2016)
BackgroundThe genetic basis of stroke susceptibility remains to be elucidated. STR1 quantitative trait locus (STR1/QTL) was identified on rat chromosome 1 of stroke‐prone spontaneously hypertensive rat (SHRSP) upon Japanese‐style stroke‐permiss
Externí odkaz: https://doaj.org/article/bb12e62f236a4526be7fb70f5772fa00
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2
Akademický článek
The C2238/αANP variant is a negative modulator of both viability and function of coronary artery smooth muscle cells.
Autor: Speranza Rubattu, Simona Marchitti, Franca Bianchi, Sara Di Castro, Rosita Stanzione, Maria Cotugno, Cristina Bozzao, Sebastiano Sciarretta, Massimo Volpe
Publikováno v: PLoS ONE, Vol 9, Iss 11, p e113108 (2014)
Abnormalities of vascular smooth muscle cells (VSMCs) contribute to development of vascular disease. Atrial natriuretic peptide (ANP) exerts important effects on VSMCs. A common ANP molecular variant (T2238C/αANP) has recently emerged as a novel vas
Externí odkaz: https://doaj.org/article/2142baa0e43c48bdb4758792528b739f
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4
Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains
Autor: Ferdinando Nicoletti, Massimo Volpe, Simona Marchitti, Michele Madonna, Speranza Rubattu, Carla L. Busceti, Franca Bianchi, Maria Cotugno, Sara Di Castro, Rosita Stanzione
Publikováno v: Oncotarget
Scopus-Elsevier
Europe PubMed Central
// Speranza Rubattu 1, 2 , Franca Bianchi 2 , Carla Letizia Busceti 2 , Maria Cotugno 2 , Rosita Stanzione 2 , Simona Marchitti 2 , Sara Di Castro 2 , Michele Madonna 2 , Ferdinando Nicoletti 2, 3 , Massimo Volpe 1, 2 1 Department of Clinical and Mol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4005576cfa706c893374be7e15d694
https://doi.org/10.18632/oncotarget.4033
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5
Pathogenesis of Target Organ Damage in Hypertension: Role of Mitochondrial Oxidative Stress
Autor: Speranza Rubattu, Giorgia Pierelli, Sara Di Castro, Caterina Santolamazza, Silvia Mennuni, Beniamino Pagliaro, Massimo Volpe
Publikováno v: International Journal of Molecular Sciences, Vol 16, Iss 1, Pp 823-839 (2014)
International Journal of Molecular Sciences
Hypertension causes target organ damage (TOD) that involves vasculature, heart, brain and kidneys. Complex biochemical, hormonal and hemodynamic mechanisms are involved in the pathogenesis of TOD. Common to all these processes is an increased bioavai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8888a27926f0413b70b79123ba4df080
https://doi.org/10.3390/ijms16010823
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6
Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease
Autor: Melinda R. Dwinell, Speranza Rubattu, Rosita Stanzione, Maria Cotugno, Gian Franco Gensini, Simona Marchitti, Sebastiano Sciarretta, Maurizia Rasura, Stefania Scarpino, Pier Mannuccio Mannucci, Sara Di Castro, Aron M. Geurts, Massimo Volpe, Samreen Falak, Flora Peyvandi, Oliver Hummel, Henrike Maatz, Betti Giusti, Ada Kura, Franca Bianchi, Norbert Hubner, Herbert Schulz
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The genetic basis of stroke susceptibility remains to be elucidated. STR 1 quantitative trait locus ( STR 1/ QTL ) was identified on rat chromosome 1 of stroke‐prone spontaneously hypertensive rat ( SHRSP ) upon Japanese‐style stroke
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7781d5ad80d1740227597d0b987feda1
http://europepmc.org/articles/PMC4802485
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8
Reactive oxygen species-mediated effects on vascular remodeling induced by human atrial natriuretic peptide T2238C molecular variant in endothelial cells in vitro
Autor: Carmine Savoia, Giovanni Quarta, Stefania Scarpino, Anna Evangelista, Massimo Volpe, Sebastiano Sciarretta, Sara Di Castro, Luigi Ruco, Speranza Rubattu, Rosita Stanzione, Simona Marchitti
Publikováno v: Journal of Hypertension. 27:1804-1813
OBJECTIVES T2238C ANP (atrial natriuretic peptide) gene variant has been associated with increased cardiovascular risk in humans and with a significant pharmacogenomic effect on cardiovascular disease outcome in hypertensive patients. We investigated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee32e8259a1ec6b55b6c23f3f660072
https://doi.org/10.1097/hjh.0b013e32832d229f
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9
Abstract P160: Role of Uncoupling Protein 2 in Stroke Susceptibility of Stroke-prone Spontaneously Hypertensive Rat
Autor: Speranza Rubattu, Maria Cotugno, Franca Bianchi, Sara Di Castro, Rosita Stanzione, Carla Busceti, Simona Marchitti, Ferdinando Nicoletti, Massimo Volpe
Publikováno v: Hypertension. 66
Mitochondrial dysfunction causes severe cellular derangements potentially underlying tissue injury and consequent diseases. Evidence of a direct involvement of mitochondrial dysfunction in hypertensive target organ damage is still poor. The gene enco
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31c16046528ff4b8375b71f61251fde7
https://doi.org/10.1161/hyp.66.suppl_1.p160
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10
Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c-Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells
Autor: Paola Spinsanti, Sara Di Castro, Teresa De Vita, Pietro Formisano, Daniela Melchiorri, Ferdinando Nicoletti, Marianna Storto
Publikováno v: Journal of Neurochemistry. 99:299-307
We have shown that endogenous activation of type 5 metabotropic glutamate (mGlu5) receptors supports the maintenance of a pluripotent, undifferentiated state in D3 mouse embryonic stem cells cultured in the presence of leukaemia inhibitory factor (LI
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b5a175bdefaa097711a1724657db2c
https://doi.org/10.1111/j.1471-4159.2006.04038.x
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