Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sara De Brouwer"'
Autor:
Bieke Decaesteker, Amber Louwagie, Siebe Loontiens, Fanny De Vloed, Sarah-Lee Bekaert, Juliette Roels, Suzanne Vanhauwaert, Sara De Brouwer, Ellen Sanders, Alla Berezovskaya, Geertrui Denecker, Eva D’haene, Stéphane Van Haver, Wouter Van Loocke, Jo Van Dorpe, David Creytens, Nadine Van Roy, Tim Pieters, Christophe Van Neste, Matthias Fischer, Pieter Van Vlierberghe, Stephen S. Roberts, Johannes Schulte, Sara Ek, Rogier Versteeg, Jan Koster, Johan van Nes, Mark Zimmerman, Katleen De Preter, Frank Speleman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
The development of neuroblastoma (NB) is regulated by multiple core transcription factors. Here, SOX11 is identified as a potential epigenetic master regulator upstream of the core regulatory circuitry in adrenergic high-risk neuroblastoma.
Externí odkaz:
https://doaj.org/article/c5e038d1e2b747e4b27f9e8e90add70c
Autor:
Ali Rihani, Tom Van Maerken, Filip Pattyn, Gert Van Peer, Anneleen Beckers, Sara De Brouwer, Candy Kumps, Evelien Mets, Joni Van der Meulen, Pieter Rondou, Carina Leonelli, Pieter Mestdagh, Frank Speleman, Jo Vandesompele
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71776 (2013)
BACKGROUND: Measuring messenger RNA (mRNA) levels using the reverse transcription quantitative polymerase chain reaction (RT-qPCR) is common practice in many laboratories. A specific set of mRNAs as internal control reference genes is considered as t
Externí odkaz:
https://doaj.org/article/bb6c9114c6fd4232a701296f6f2866ff
Autor:
Candy Kumps, Annelies Fieuw, Pieter Mestdagh, Björn Menten, Steve Lefever, Filip Pattyn, Sara De Brouwer, Tom Sante, Johannes Hubertus Schulte, Alexander Schramm, Nadine Van Roy, Tom Van Maerken, Rosa Noguera, Valérie Combaret, Christine Devalck, Frank Westermann, Geneviève Laureys, Angelika Eggert, Jo Vandesompele, Katleen De Preter, Frank Speleman
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52321 (2013)
Neuroblastoma is an embryonic tumor arising from immature sympathetic nervous system cells. Recurrent genomic alterations include MYCN and ALK amplification as well as recurrent patterns of gains and losses of whole or large partial chromosome segmen
Externí odkaz:
https://doaj.org/article/a21cfe8ab66d4212bb3b532098e03569
Autor:
Tim Lammens, Katrien Swerts, Lara Derycke, Annemie De Craemer, Sara De Brouwer, Katleen De Preter, Nadine Van Roy, Jo Vandesompele, Frank Speleman, Jan Philippé, Yves Benoit, Klaus Beiske, Marc Bracke, Geneviève Laureys
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31206 (2012)
One of the first and most important steps in the metastatic cascade is the loss of cell-cell and cell-matrix interactions. N-cadherin, a crucial mediator of homotypic and heterotypic cell-cell interactions, might play a central role in the metastasis
Externí odkaz:
https://doaj.org/article/341036671ef5438a9a264bb8ce156bbd
Autor:
Frank Speleman, Rogier Versteeg, Jan Cools, Angelika Eggert, Huib Caron, Miki Ohira, Akira Nakagawara, Tommy Martinsson, Per Kogner, Isabelle Janoueix-Lerosey, Olivier Delattre, Rosa Noguera, Marleen Renard, Klaus Beiske, Nadine Van Roy, Joëlle Vermeulen, Caroline Van Den Broecke, Alexander Schramm, Johannes H. Schulte, Geneviève Laureys, Anne De Paepe, Tom Van Maerken, Jasmien Hoebeeck, Jo Vandesompele, Arjan Lakeman, Ellen M. Westerhout, Michaël Porcu, Piotr Zabrocki, Candy Kumps, Katleen De Preter, Sara De Brouwer
PDF file - 1.29MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82107809a8b7b9376db08ebd380298f
https://doi.org/10.1158/1078-0432.22440859.v1
https://doi.org/10.1158/1078-0432.22440859.v1
Autor:
Glenn M. Marshall, Belamy B. Cheung, Frank Speleman, Katleen De Preter, Tao Liu, Michelle Haber, Murray D. Norris, Tzong-Tyng Hung, Bieke Decaesteker, Sara De Brouwer, Zsuzsanna Nagy, Amit Lalwani, Anneleen Beckers, Chelsea Mayoh, Bing Liu, Daniel R. Carter, Chi Yan Ooi
Neuroblastoma is a pediatric cancer of the sympathetic nervous system where MYCN amplification is a key indicator of poor prognosis. However, mechanisms by which MYCN promotes neuroblastoma tumorigenesis are not fully understood. In this study, we an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67fa4f9c3355d1540e5a177237cce8c3
https://doi.org/10.1158/0008-5472.c.6510648.v1
https://doi.org/10.1158/0008-5472.c.6510648.v1
Autor:
Frank Speleman, Jo Vandesompele, Angelika Eggert, Alexander Schramm, Filip Pattyn, Tom Van Maerken, Sara De Brouwer, Katleen De Preter
Purpose: Neuroblastoma is a heterogeneous childhood tumor with poor survival outcome for the aggressive type despite intensive multimodal therapies. In this study, we aimed to identify new treatment options for neuroblastoma based on integrative geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1854d28bda5c092189cd94ffa604bf
https://doi.org/10.1158/1078-0432.c.6517924
https://doi.org/10.1158/1078-0432.c.6517924
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 9: Summary of Gene Set Enrichment analysis results performed on expression data upon ALK inhibition in 10 cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8ba2b9fbd5cfbaa48dbc06a331da43
https://doi.org/10.1158/1078-0432.22459751.v1
https://doi.org/10.1158/1078-0432.22459751.v1
Autor:
Frank Speleman, Rogier Versteeg, Jan Cools, Angelika Eggert, Huib Caron, Miki Ohira, Akira Nakagawara, Tommy Martinsson, Per Kogner, Isabelle Janoueix-Lerosey, Olivier Delattre, Rosa Noguera, Marleen Renard, Klaus Beiske, Nadine Van Roy, Joëlle Vermeulen, Caroline Van Den Broecke, Alexander Schramm, Johannes H. Schulte, Geneviève Laureys, Anne De Paepe, Tom Van Maerken, Jasmien Hoebeeck, Jo Vandesompele, Arjan Lakeman, Ellen M. Westerhout, Michaël Porcu, Piotr Zabrocki, Candy Kumps, Katleen De Preter, Sara De Brouwer
Purpose: Activating mutations of the anaplastic lymphoma kinase (ALK) were recently described in neuroblastoma. We carried out a meta-analysis of 709 neuroblastoma tumors to determine their frequency and mutation spectrum in relation to genomic and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22eda6bf8d9c14bdd864788a994a7ed0
https://doi.org/10.1158/1078-0432.c.6518119
https://doi.org/10.1158/1078-0432.c.6518119
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 13: Summary of Gene Set Enrichment analysis results obtained on expression profiling data of CLB-Ââ€�GA on different time points (10' - 30'- 60' - 2h - 4h - 6h) after pharmacological inhibition using TAE-Ââ€�684.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25178759ac101de20553303d661c8c67
https://doi.org/10.1158/1078-0432.22459757.v1
https://doi.org/10.1158/1078-0432.22459757.v1