Erratum for Siegel et al., 'Structure and Mechanism of LcpA, a Phosphotransferase That Mediates Glycosylation of a Gram-Positive Bacterial Cell Wall-Anchored Protein'

Autor: Sara D. Siegel, Brendan R. Amer, Chenggang Wu, Michael R. Sawaya, Jason E. Gosschalk, Robert T. Clubb, Hung Ton-That

Publikováno v: mBio, Vol 10, Iss 2 (2019)

Externí odkaz: https://doaj.org/article/b9d1b7c32a82485d87e64bd426f97bdd

A conserved signal-peptidase antagonist modulates membrane homeostasis of actinobacterial sortase critical for surface morphogenesis

Autor: Nicholas A. Ramirez, Chenggang Wu, Chungyu Chang, Sara D. Siegel, Asis Das, Hung Ton-That

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(28)

Most Actinobacteria encode a small transmembrane protein, whose gene lies immediately downstream of the housekeeping sortase coding for a transpeptidase that anchors many extracellular proteins to the Gram-positive bacterial cell wall. Here, we uncov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2982d24bc18b44129c468028cd1ab2
https://pubmed.ncbi.nlm.nih.gov/35787040

MglA/SspA complex interactions are modulated by inorganic polyphosphate.

Autor: Algevis P Wrench, Christopher L Gardner, Sara D Siegel, Fernando A Pagliai, Mahsa Malekiha, Claudio F Gonzalez, Graciela L Lorca

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e76428 (2013)

The transcription factors MglA and SspA of Francisella tularensis form a heterodimer complex and interact with the RNA polymerase to regulate the expression of the Francisella pathogenicity island (FPI) genes. These genes are essential for this patho

Externí odkaz: https://doaj.org/article/e532fd4178704e45842d22720ccbee48

Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in Enterococcus faecalis

Autor: Ayesha Khan, Orville Pemberton, Diana Panesso, Truc T. Tran, Rafael Rios, Paul J. Planet, Sara D. Siegel, Cesar A. Arias, Sandra Rincon, Danielle A. Garsin, Hung Ton-That, Jinnethe Reyes, Milya Davlieva, Lorena Diaz, Melissa R. Cruz, April H. Nguyen, Yousif Shamoo, Kavindra V. Singh, William R. Miller, Apurva Narechania, Mauricio Latorre

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 52
Repositorio U. El Bosque
Universidad El Bosque
instacron:Universidad El Bosque

Bacteria have developed several evolutionary strategies to protect their cell membranes (CMs) from the attack of antibiotics and antimicrobial peptides (AMPs) produced by the innate immune system, including remodeling of phospholipid content and loca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606aa1dc7abfe6461eecb381a3a01533
https://escholarship.org/uc/item/8j65h21n

Structure and Mechanism of LcpA, a Phosphotransferase That Mediates Glycosylation of a Gram-Positive Bacterial Cell Wall-Anchored Protein

Autor: Jason E. Gosschalk, Chenggang Wu, Brendan R. Amer, Sara D. Siegel, Hung Ton-That, Robert T. Clubb, Michael R. Sawaya

Publikováno v: mBio
mBio, vol 10, iss 1
mBio, Vol 10, Iss 1, p e01580-18 (2019)
mBio, Vol 10, Iss 1 (2019)

In Gram-positive bacteria, the conserved LCP family enzymes studied to date are known to attach glycopolymers, including wall teichoic acid, to the cell envelope. It is unknown if these enzymes catalyze glycosylation of surface proteins. We show here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b8b954f183ef7f8da8241e5b357959
https://pubmed.ncbi.nlm.nih.gov/30992357