Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Sara Chirayil"'
Autor:
Eul Hyun Suh, Carlos F. G. C. Geraldes, Sara Chirayil, Brandon Faubert, Raul Ayala, Ralph J. DeBerardinis, A. Dean Sherry
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-10 (2021)
Abstract Background Excessive lactate production, a hallmark of cancer, is largely formed by the reduction of pyruvate via lactate dehydrogenase (LDH) to l-lactate. Although d-lactate can also be produced from glucose via the methylglyoxal pathway in
Externí odkaz:
https://doaj.org/article/aa4e4f7bf1184b3ea910f6a8758f378c
Autor:
Bibek Thapa, Eul Hyun Suh, Daniel Parrott, Pooyan Khalighinejad, Gaurav Sharma, Sara Chirayil, A. Dean Sherry
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2022)
An imaging method for detecting β-cell function in real-time in the rodent pancreas could provide new insights into the biological mechanisms involving loss of β-cell function during development of type 2 diabetes and for testing of new drugs desig
Externí odkaz:
https://doaj.org/article/9d3efc7e2cc640f99933a0f46e2e6e3e
Autor:
Veronica Clavijo Jordan, Catherine D. G. Hines, Liza T. Gantert, Shubing Wang, Stacey Conarello, Christian Preihs, Sara Chirayil, Michael Klimas, Jeffrey L. Evelhoch, A. Dean Sherry
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Non-invasive beta cell function measurements may provide valuable information for improving diabetes diagnostics and disease management as the integrity and function of pancreatic beta cells have been found to be compromised in Type-1 and Type-2 diab
Externí odkaz:
https://doaj.org/article/fc97c59679444ff39cabae396fbd4b0b
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108231 (2014)
We have used NMR spectroscopy to characterize an oligonucleotide stem loop structure based on the pre-element of an oncogenic microRNA, miR-21. This predicted stem-loop structure is cleaved from the precursor of miR-21 (pre-miR-21) by the nuclease Di
Externí odkaz:
https://doaj.org/article/e79407be54ee4a84af607dfca785ae1e
Autor:
S. James Ratnakar, Sara Chirayil, Alexander M. Funk, Shanrong Zhang, João F. Queiró, Carlos F. G. C. Geraldes, Zoltan Kovacs, A. Dean Sherry
Publikováno v:
Angewandte Chemie. 132:21855-21860
Autor:
Zoltan Kovacs, S. James Ratnakar, Sara Chirayil, A. Dean Sherry, Alexander M. Funk, Shanrong Zhang, Carlos F. G. C. Geraldes, João Filipe Queiró
Publikováno v:
Angew Chem Int Ed Engl
Extracellular pH is an important biomarker in many diseases yet a routine method for imaging tissue pH has not been established in the clinic. Paramagnetic chemical exchange saturation transfer (paraCEST) agents are well-suited for imaging tissue pH
Autor:
Bibek Thapa, Eul Hyun Suh, Daniel Parrott, Pooyan Khalighinejad, Gaurav Sharma, Sara Chirayil, A. Dean Sherry
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2022)
An imaging method for detecting β-cell function in real-time in the rodent pancreas could provide new insights into the biological mechanisms involving loss of β-cell function during development of type 2 diabetes and for testing of new drugs desig
Autor:
A. Dean Sherry, Carlos F. G. C. Geraldes, Eul Hyun Suh, Sara Chirayil, Brandon Faubert, Raul Ayala, Ralph J. DeBerardinis
Publikováno v:
Cancer & Metabolism
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-10 (2021)
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-10 (2021)
Background Excessive lactate production, a hallmark of cancer, is largely formed by the reduction of pyruvate via lactate dehydrogenase (LDH) to l-lactate. Although d-lactate can also be produced from glucose via the methylglyoxal pathway in small am
Autor:
Kalotina Geraki, Michael J. Farquharson, Sara Chirayil, A. Dean Sherry, Alia Al-Ebraheem, Erica Dao, André F. Martins, Veronica Clavijo Jordan
Publikováno v:
Inorg Chem
Prostatic zinc content is a known biomarker for discriminating normal healthy tissue from benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Given that zinc content is not readily measured without a tissue biopsy, we have been exploring no
Autor:
A. Dean Sherry, Neil M. Rofsky, Christian Preihs, Pooyan Khalighinejad, Daniel Parrott, Veronica Clavijo Jordan, Yin Xi, Sara Chirayil
Publikováno v:
Invest Radiol
OBJECTIVES: In the United States, prostate cancer (PCa) is the most common cancer in men. Multi-parametric magnetic resonance imaging (MRI) is increasingly being relied upon for the diagnosis and characterization of PCa, but differentiating malignanc