The white matter is a pro-differentiative niche for glioblastoma

Autor: Lucy J. Brooks, Melanie P. Clements, Jemima J. Burden, Daniela Kocher, Luca Richards, Sara Castro Devesa, Leila Zakka, Megan Woodberry, Michael Ellis, Zane Jaunmuktane, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Peter B. Dirks, Samuel Marguerat, Simona Parrinello

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Glioma stem cells (GSCs) retain the ability to partially differentiate, but it is unclear how the brain microenvironment may influence this response. Here the authors show that glioblastoma cells infiltrating into the white matter acquire pre-oligode

Externí odkaz: https://doaj.org/article/1dfd4c8671124520ac4d6ba779864aae

The white matter is a pro-differentiative niche for glioblastoma

Autor: Jemima J. Burden, Lucy Brooks, Zane Jaunmuktane, Daniela Kocher, Simona Parrinello, Megan Woodberry, Luca Richards, Leila Zakka, Steven M. Pollard, Sebastian Brandner, Melanie Clements, Peter B. Dirks, Michael J. Ellis, Gillian Morrison, Samuel Marguerat, Sara Castro Devesa

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Brooks, L J, Clements, M P, Burden, J J, Kocher, D, Richards, L, Devesa, S C, Zakka, L, Woodberry, M, Ellis, M, Jaunmuktane, Z, Brandner, S, Morrison, G, Pollard, S M, Dirks, P B, Marguerat, S & Parrinello, S 2021, ' The white matter is a pro-differentiative niche for glioblastoma ', Nature Communications, vol. 12, no. 1, pp. 2184 . https://doi.org/10.1038/s41467-021-22225-w
Nature Communications

Glioblastomas are hierarchically organised tumours driven by glioma stem cells that retain partial differentiation potential. Glioma stem cells are maintained in specialised microenvironments, but whether, or how, they undergo lineage progression out

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c97b883e7b966040527328ba18effa
https://doaj.org/article/1dfd4c8671124520ac4d6ba779864aae