Clinical trajectories of patients with multiple sclerosis from onset and their relationship with serum neurofilament light chain levels

Autor: Carlos Quintanilla-Bordás, Laura Cubas-Núñez, Jéssica Castillo-Villalba, Sara Carratalá-Boscá, Raquel Gasque-Rubio, Jordi Tortosa-Carreres, Carmen Alcalá, Lorena Forés-Toribio, Celia Lucas, David Gorriz, Francisco Pérez-Miralles, Bonaventura Casanova

Publikováno v: Frontiers in Neurology, Vol 15 (2024)

BackgroundSerum neurofilament light chain (sNfL) is a biomarker of neuroaxonal destruction that correlates with acute inflammation (AI) in multiple sclerosis (MS). However, in the treatment era, progression without AI is the main driver of long-term

Externí odkaz: https://doaj.org/article/67253ab10c5a429da0f649fed3c9eb0c

Determinación del Índice de Importancia Relativa en Oreochromis sp cultivadas con biofloc y alimento balanceado

Autor: Eulalia Ibarra Mayorga, Sara Carratalá Hurtado, Jonathan Proaño Morales

Publikováno v: La Técnica: Revista de las Agrociencias, Iss 14, Pp 62-71 (2015)

El objetivo de este estudio fue determinar el Índice de Importancia Relativa en tilapias (Oreochromis sp) cultivadas con biofloc y alimento balanceado, con el fin de identificar que fuente alimenticia era consumida de manera preferente por estos pec

Externí odkaz: https://doaj.org/article/98335808d373481e9269cffc7899c933

Effectiveness of rituximab vs. ocrelizumab for the treatment of primary progressive multiple sclerosis: a real-world observational study

Autor: Carmen Alcalá, Carlos Quintanilla-Bordás, Francisco Gascón, Ángel Perez Sempere, Laura Navarro, María Carcelén-Gadea, Lamberto Landete, Javier Mallada, Emmanuel Cañizares, Antonio Belenguer, Sara Carratalá, José Andrés Domínguez, Francisco Carlos Pérez-Miralles, Sara Gil-Perotín, Raquel Gasqué, Laura Cubas, Jéssica Castillo, Bonaventura Casanova

Publikováno v: JOURNAL OF NEUROLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

INTRODUCTION: Ocrelizumab, an antiCD-20 antibody, is the only drug approved to treat patients with primary progressive multiple sclerosis (pwPPMS). Not all candidates receive this treatment due to prescription limitations. Rituximab, another antiCD-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22f3fdc54a67c5fc939cd8c8405718e
https://pubmed.ncbi.nlm.nih.gov/35107597

Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis

Autor: Carmen Alcalá Vicente, Laura Lacruz, Francisco Gascón, Sara Carratalà, Carlos Quintanilla-Bordás, Maria T. Sanz, María Carcelén-Gadea, Javier Mallada, Joan Carreres, Laura Gabaldón Torres, Jose Andres Dominguez, Emmanuel Cañizares, Sara Gil-Perotin, Laura Cubas, Raquel Gasqué Rubio, Jéssica Castillo-Villalba, Francisco Carlos Pérez-Miralles, Bonaventura Casanova

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

ObjectiveTo determine baseline cerebrospinal fluid and magnetic resonance imaging (MRI) variables at the onset of a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) that predict evolution to secondary progressive MS (SPMS).Met

Externí odkaz: https://doaj.org/article/6a03ba357ba243c6850fe579843e91f3

High Levels of Cerebrospinal Fluid Kappa Free Light Chains Relate to IgM Intrathecal Synthesis and Might Have Prognostic Implications in Relapsing Multiple Sclerosis

Autor: Jéssica Castillo-Villalba, Sara Gil-Perotín, Raquel Gasque-Rubio, Laura Cubas-Nuñez, Sara Carratalà-Boscà, Carmen Alcalá, Carlos Quintanilla-Bordás, Francisco Pérez-Miralles, Cristina Ferrer, Antonio Cañada Martínez, Jordi Tortosa, Luís Solís-Tarazona, Luisa Campos, Alberto Leivas, Begoña Laíz Marro, Bonaventura Casanova

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Cerebrospinal kappa free light chain (KFLC)-index is a marker of intrathecal immunoglobulin synthesis that aids in the diagnosis of multiple sclerosis (MS). However, little evidence exists on its prognostic role. Our aim is to analyze the relationshi

Externí odkaz: https://doaj.org/article/b2a1c9817f794ef9b56f12e0b8ea37c3