Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sara C. Atherley"'
Autor:
Ninoschka C. D’Souza, Julian A. Aiken, Emily G. Hoffman, Sara C. Atherley, Sabrina Champsi, Nadia Aleali, Dorsa Shakeri, Maya El-Zahed, Nicky Akbarian, Mehran Nejad-Mansouri, Parinaz Z. Bavani, Richard L. Liggins, Owen Chan, Michael C. Riddell
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Elevated levels of somatostatin blunt glucagon counterregulation during hypoglycemia in type 1 diabetes (T1D) and this can be improved using somatostatin receptor 2 (SSTR2) antagonists. Hypoglycemia also occurs in late-stage type 2 diabet
Externí odkaz:
https://doaj.org/article/d6004c849ef2466b9d45505754e327f6
Autor:
EMILY G. HOFFMAN, SARA C. ATHERLEY, NICKY AKBARIAN, NINOSCHKA DSOUZA, RICHARD LIGGINS, MICHAEL RIDDELL
Publikováno v:
Diabetes. 71
Background: Pancreatic islet remodelling in type 1 diabetes increases somatostatin (SST) expression, which inhibits glucagon counterregulation to hypoglycemia. Here, we characterized islet morphology and hormone composition in a rodent model of insul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d72bf67469b013b1c0267c9a3f3d630
https://doi.org/10.2337/db22-9-lb
https://doi.org/10.2337/db22-9-lb
Autor:
Emily G. Hoffman, Ninoschka C. D’Souza, Michael C. Riddell, Mariya Popkov, Sara C. Atherley, Richard Liggins, Sabrina Champsi
Publikováno v:
Diabetes. 70
Background: Defective glucagon counterregulation to hypoglycemia in T1D involves elevated somatostatin signalling on the α cell. In rats, SSTR2a treatment (ZT-01 Methods: High fat fed, low dose streptozotocin (T2D) and healthy rats were treated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25faa2193791b36810a931ef2c2bfb14
https://doi.org/10.2337/db21-1197-p
https://doi.org/10.2337/db21-1197-p