Výsledky vyhledávání - "Sara C Hughes"

Discovery of a rapidly metabolized, long-acting β(2) adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing

Autor: Peter R. Butchers, Victoria J. Barrett, Peter J. Mutch, Andrew P. Craven, Sara C Hughes, Mark Ruston, Duncan S. Holmes, Alison J. Ford, Keith Biggadike, Brian Edgar Looker, Stephen Barry Guntrip, Anne Jones, Deborah Needham, Panayiotis A. Procopiou, Claire E. Smith

Publikováno v: Journal of medicinal chemistry. 57(1)

A series of novel, potent, and selective human β2 adrenoceptor agonists incorporating a sulfone moiety on the terminal right-hand-side phenyl ring of (R)-salmeterol is presented. Sulfone 10b had salmeterol-like potency and selectivity profile, long

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b6472cee081248047681c7f3def8d6
https://pubmed.ncbi.nlm.nih.gov/24359185

Zobrazit plný text záznamu

In Vitro And In Vivo Pharmacological Characterisation Of GW642444, A Novel Long-acting ²2 Agonist (LABA), With Fast Onset And Long Duration In The Guinea-pig

Autor: Sara C Hughes, Valerie S. Morrison, Victoria J. Barrett, Richard G. Knowles, Alison J. Ford

Publikováno v: D34. NOVEL THERAPEUTIC OPTIONS IN AIRWAYS DISEASE.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8684661dda4586d0b1880cb6d9650763
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5677

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání