Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Sara Boiani"'
Autor:
Martyn J Hiscox, Alexandra Wasmuth, Chris L Williams, Jaelle N Foot, Guy E Wiedermann, Valeria Fadda, Sara Boiani, Terri V Cornforth, Karolina A Wikiert, Shaun Bruton, Neil Cartwright, Victoria Elizabeth Anderson, Christopher S Barnes, Joao V Vieira, Ian Birch-Machin, Andrew B Gerry, Karen Miller, Nicholas J Pumphrey
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301175 (2024)
BackgroundCanonical α/β T-cell receptors (TCRs) bind to human leukocyte antigen (HLA) displaying antigenic peptides to elicit T cell-mediated cytotoxicity. TCR-engineered T-cell immunotherapies targeting cancer-specific peptide-HLA complexes (pHLA)
Externí odkaz:
https://doaj.org/article/45b738a8ccec4feaa6830e4837506529
Autor:
Geoffrey W. Butcher, Martin R Turner, Rebecca Leyland, Rinako Nakagawa, Philipp Staudacher, Alison Galloway, Dong Lu, Tom Henley, Elena Vigorito, Sara Boiani, Cei Abreu-Goodger, Simon Andrews, Stephen L. Nutt, Sandra Lazzaro
Publikováno v:
The Journal of Experimental Medicine
Lu, D, Nakagawa, R, Lazzaro, S, Staudacher, P, Abreu-Goodger, C, Henley, T, Boiani, S, Leyland, R, Galloway, A, Andrews, S, Butcher, G, Nutt, S L, Turner, M & Vigorito, E 2014, ' The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation ', Journal of Experimental Medicine, vol. 211, no. 11, pp. 2183–2198 . https://doi.org/10.1084/jem.20140338
Lu, D, Nakagawa, R, Lazzaro, S, Staudacher, P, Abreu-Goodger, C, Henley, T, Boiani, S, Leyland, R, Galloway, A, Andrews, S, Butcher, G, Nutt, S L, Turner, M & Vigorito, E 2014, ' The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation ', Journal of Experimental Medicine, vol. 211, no. 11, pp. 2183–2198 . https://doi.org/10.1084/jem.20140338
Lu et al. disrupt the interaction between miR-155 and the transcription factor PU.1 by specifically removing miR-155–binding site from PU.1 mRNA in mice. They show that this interaction is required for plasma cell formation and extrafollicular resp