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Akademický článek

IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules

Autor: Sara Bisi, Stefano Marchesi, Abrar Rizvi, Davide Carra, Galina V. Beznoussenko, Ines Ferrara, Gianluca Deflorian, Alexander Mironov, Giovanni Bertalot, Federica Pisati, Amanda Oldani, Angela Cattaneo, Ghazaleh Saberamoli, Salvatore Pece, Giuseppe Viale, Angela Bachi, Claudio Tripodo, Giorgio Scita, Andrea Disanza

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-23 (2020)

The I-BAR protein IRSp53 senses membrane curvature but its physiological role is unclear. Here, the authors show that during early lumen morphogenesis, IRSp53 controls the shape of the apical plasma membrane and polarized trafficking and ensures the

Externí odkaz: https://doaj.org/article/536a71339aa54d258f9d3f43f9fc0c19

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IRSp53 shapes the plasma membrane and controls polarized transport at the nascent lumen during epithelial morphogenesis

Autor: Andrea Disanza, Angela Bachi, Giovanni Bertalot, Salvatore Pece, Ines Ferrara, Amanda Oldani, Claudio Tripodo, Gianluca Deflorian, Galina V. Beznoussenko, Federica Pisati, Rizvi Sa, Giuseppe Viale, Alexandre A. Mironov, Giorgio Scita, Angela Cattaneo, Carra D, Sara Bisi, Stefano Marchesi

Establishment of apical–basal cell polarity is necessary for generation of luminal and tubular structures during epithelial morphogenesis. Molecules acting at the membrane/ actin interface are expected to be crucial in governing these processes. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e65565d9cd9642907cb1873858329ae

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Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation

Autor: Sara Gallini, Marina Mapelli, Andrea Alfieri, Sara Bisi, Manuel Carminati, Laura Pirovano

Publikováno v: Nature Structural & Molecular Biology. 23:155-163

Polarized epithelia form by oriented cell divisions in which the mitotic spindle aligns parallel to the epithelial plane. To orient the mitotic spindle, cortical cues trigger the recruitment of NuMA-dynein-based motors, which pull on astral microtubu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fddb96fea489feb1626cf53cd3aec48c
https://doi.org/10.1038/nsmb.3152

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A NUMB–EFA6B–ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility

Autor: Sara Sigismund, Philippe Chavrier, Giorgio Scita, Pier Paolo Di Fiore, Andrea Disanza, Elisa Barbieri, Francesca Senic-Matuglia, Ivan Nicola Colaluca, Stefano Confalonieri, Giusi Caldieri, Michel Franco, Martina Zobel, Sara Bisi, Salvatore Pece

Publikováno v: Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2018, 217 (9), pp.3161-3182. ⟨10.1083/jcb.201802023⟩
The Journal of Cell Biology

How the endocytic protein NUMB modulates mesenchymal migration is unclear. Zobel et al. show that NUMB limits the formation of apically restricted, actin-based protrusions called circular dorsal ruffles (CDRs). NUMB activates the ARF6 guanine nucleot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12593b5f030445e7aee5ca1a2089d9d9
https://hal.archives-ouvertes.fr/hal-02349236/document

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The CDC42-Interacting Protein 4 Controls Epithelial Cell Cohesion and Tumor Dissemination

Autor: Paola Marighetti, Chiara Luise, Olga G. Shcherbakova, Nadia Ducano, Hiroaki Kajiho, Letizia Lanzetti, Stefano Confalonieri, Amanda Oldani, Andrea Palamidessi, Sara Bisi, Yannève Rolland, Pier Paolo Di Fiore, Chiara Malinverno, Giorgio Scita, Andrea Disanza, Alexander R. Dunn, Flavia Troglio

Publikováno v: Developmental Cell. 30:553-568

SummaryThe role of endocytic proteins and the molecular mechanisms underlying epithelial cell cohesion and tumor dissemination are not well understood. Here, we report that the endocytic F-BAR-containing CDC42-interacting protein 4 (CIP4) is required

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a160a8146307ed8c7c6b19dc8a57a1b
https://doi.org/10.1016/j.devcel.2014.08.006

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Is cell migration a selectable trait in the natural evolution of cancer development?

Autor: Sara Bisi, Abrar Rizvi, Chiara Malinverno, Andrea Palamidessi, Emanuela Frittoli, Giorgio Scita, Andrea Disanza, Stefano Marchesi

Publikováno v: Philos Trans R Soc Lond B Biol Sci

Selective evolutionary pressure shapes the processes and genes that enable cancer survival and expansion in a tumour-suppressive environment. A distinguishing lethal feature of malignant cancer is its dissemination and seeding of metastatic foci. A k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca852270351eafe05192b9b091a7534d
https://doi.org/10.1098/rstb.2018.0224

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Membrane and actin dynamics interplay at lamellipodia leading edge

Autor: Chiara Malinverno, Andrea Palamidessi, Giorgio Scita, Emanuela Frittoli, Sara Bisi, Andrea Disanza

Publikováno v: Current Opinion in Cell Biology

The multimolecular WAVE regulatory (WRC) and Arp2/3 complexes are primarily responsible to generate pushing forces at migratory leading edges by promoting branch elongation of actin filaments. The architectural complexity of these units betrays the n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae7970a21acaf3d5b626d8c0f111818
https://doi.org/10.1016/j.ceb.2013.04.001

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CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP

Autor: Moritz Winterhoff, Christophe Ampe, Giorgio Scita, David J. Kast, Andrea Disanza, Hans-Michael Müller, Paola Marighetti, Francesca Milanesi, Joern Linkner, Salvatore Cortellino, Jan Faix, Roberto Dominguez, Dmitry S. Ushakov, Davy Waterschoot, Marie-France Carlier, Sara Bisi, Andrea Palamidessi, Walter Nickel, Guillaume Romet-Lemonne

Publikováno v: The EMBO Journal; Vol 32
The EMBO Journal

Filopodia explore the environment, sensing soluble and mechanical cues during directional motility and tissue morphogenesis. How filopodia are initiated and spatially restricted to specific sites on the plasma membrane is still unclear. Here, we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0017c1e4fd489c424fb6e5282345f91a

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Rab2 promotes autophagic and endocytic lysosomal degradation

Autor: Péter Lőrincz, Péter Benkő, Sarolta Tóth, Gábor Glatz, Attila Boda, Sara Bisi, Martina Zobel, Szabolcs Takáts, Zsolt Lakatos, Gábor Juhász, Krisztina Hegedűs, Giorgio Scita

Publikováno v: The Journal of Cell Biology

Rab7 promotes fusion of autophagosomes and late endosomes with lysosomes. Lőrincz et al. show that Rab2 is critical for the delivery of autophagic and endocytic cargo to lysosomes and for their degradation, and that it promotes autophagosome–lysos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376705c43551570e67a81bc69711eb9a
https://pubmed.ncbi.nlm.nih.gov/28483915

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Mechanism of Interaction of Novel Indolylarylsulfone Derivatives with K103N and Y181I Mutant HIV-1 Reverse Transcriptase in Complex with its Substrates

Autor: Francesco Piscitelli, Alberta Samuele, Giuseppe La Regina, Giovanni Maga, Romano Silvestri, Sara Bisi, Alexandra Kataropoulou, Valerio Gatti

Publikováno v: Antiviral Chemistry and Chemotherapy. 22:107-118

Background: Novel indolylarylsulfones (lASs), designed through rational structure-based molecular modelling and docking approaches, have been recently characterized as effective inhibitors of the wild-type and drug-resistant mutant HIV-1 reverse tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383e0284104a5f0b30d61379c92375c0
https://doi.org/10.3851/imp1855

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