Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sara Bermudez"'
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0281045 (2023)
Reactive oxygen species (ROS) are a contributing factor to impaired function and pathology after spinal cord injury (SCI). The NADPH oxidase (NOX) enzyme is a key source of ROS; there are several NOX family members, including NOX2 and NOX4, that may
Externí odkaz:
https://doaj.org/article/4f2e03150ba34de892f86e2a9daf71dd
Autor:
Young J. Yauger, Sara Bermudez, Kasey E. Moritz, Ethan Glaser, Bogdan Stoica, Kimberly R. Byrnes
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Excessive iron contributes to oxidative stress after central nervous system injury. NADPH oxidase (NOX) enzymes are upregulated in microglia after pro-inflammatory activation and contribute to oxidative stress. The relationship be
Externí odkaz:
https://doaj.org/article/0e25b285c80f45c9986786ddc117ebdb
Autor:
Nahum Sonenberg, Peng Wang, Zixian Li, Sunghoon Kim, Hao Huang, Jung-Hyun Choi, Haijin Xu, chutong yang, Abby Snape, Sara Bermudez, Marie-Noëlle Boivin, Nicolas Ferry, Rapita Sood, Vijendra Sharma, Joel Ryan, Morag Park, Jason Karamchandani, Bhushan Nagar
The mRNA 5’cap-binding eukaryotic translation initiation factor 4E (eIF4E) plays a major role in control of mRNA translation in health and disease. One mechanism of regulation of eIF4E activity is via phosphorylation of eIF4E by MNK kinases, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87f494f1ea764a004aa62c729edff2b0
https://doi.org/10.21203/rs.3.rs-2847028/v1
https://doi.org/10.21203/rs.3.rs-2847028/v1
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201878 (2018)
Microglia are the macrophages of the central nervous system (CNS), which function to monitor and maintain homeostasis. Microglial activation occurs after CNS injury, infection or disease. Prolonged microglial activation is detrimental to the CNS as t
Externí odkaz:
https://doaj.org/article/b2b3f7d436c345bba11b407eb124095b
Autor:
Angélica Torres-Berrío, Gareth M. Rurak, Mohammad J. Eslamizade, Natalina Salmaso, Danilo De Gregorio, Argel Aguilar-Valles, Agnieszka Skaleka, Martha Lopez-Canul, Nahum Sonenberg, Sara Bermudez, Jean-Claude Lacaille, Abdessattar Khlaifia, Gabriella Gobbi, Edna Matta-Camacho, Stephanie Simard
Publikováno v:
Nature. 590:315-319
Effective pharmacotherapy for major depressive disorder remains a major challenge, as more than 30% of patients are resistant to the first line of treatment (selective serotonin reuptake inhibitors)1. Sub-anaesthetic doses of ketamine, a non-competit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc88ff9818874d4ab07a501e9c06d9f2
https://doi.org/10.1038/s41586-020-03047-0
https://doi.org/10.1038/s41586-020-03047-0
Autor:
Kasey E. Moritz, Colin M. Wilson, Kimberly R. Byrnes, Bernard J. Dardzinski, Ramona E. von Leden, Shalini Jaiswal, Sara Bermudez
Publikováno v:
Neuroscience Letters. 690:23-28
Aging results in increased activation of inflammatory glial cells and decreased neuronal viability following spinal cord injury (SCI). Metabolism and transport of glucose is also decreased with age, although the influence of age on glucose transporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6428455b3d1b02ae75ef74fae20a092b
https://doi.org/10.1016/j.neulet.2018.10.004
https://doi.org/10.1016/j.neulet.2018.10.004
Autor:
Natasha Saviuk, Yumaine Chong, Peng Wang, Sara Bermudez, Zhe Zhao, Arjun A. Bhaskaran, Derek Bowie, Nahum Sonenberg, Ellis Cooper, A. Pejmun Haghighi
Publikováno v:
Cell reports. 39(10)
Genetic perturbances in translational regulation result in defects in cerebellar motor learning; however, little is known about the role of translational mechanisms in the regulation of cerebellar plasticity. We show that genetic removal of 4E-BP, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc39287aa0fb392ec58d2de4a2c72d1
https://pubmed.ncbi.nlm.nih.gov/35675781
https://pubmed.ncbi.nlm.nih.gov/35675781
Autor:
Sara Bermudez, Raquel Diz-Gil, José M. Vila, Juan M. Ortigueira, Paula Munín-Cruz, Marcos Rúa-Sueiro
Publikováno v:
Proceedings of The 24th International Electronic Conference on Synthetic Organic Chemistry.
The synthesis of palladium cyclometallated compounds with thiosemicarbazone ligands is described,as well as their reactivity with bidentate phosphine ligands. The synthesis of the ligands is carried out by a condensation reaction between a ketone and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b5d2476a2d37e6e1020a0303337b4d
https://doi.org/10.3390/ecsoc-24-08320
https://doi.org/10.3390/ecsoc-24-08320
Autor:
Reed Selwyn, Fiona Brabazon, Kimberly R. Byrnes, Colin M. Wilson, Sanjeev Mathur, Shalini Jaiswal, Sara Bermudez, Dinesh K Shukla
Publikováno v:
Journal of Neurotrauma. 34:1074-1085
Non-invasive measurements of brain metabolism using 18F-fluorodeoxyglucose (FDG) with positron emission tomography (PET) may provide important information about injury severity following traumatic brain injury (TBI). There is growing interest in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75570bed1cd75812ff2701ef65f6194f
https://doi.org/10.1089/neu.2016.4540
https://doi.org/10.1089/neu.2016.4540
Publikováno v:
Molecular and Cellular Neuroscience. 77:53-64
Spinal cord injury (SCI) results in both acute and chronic inflammation, as a result of activation of microglia, invasion of macrophages and activation of the NADPH oxidase (NOX) enzyme. The NOX enzyme is a primary source of reactive oxygen species (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9091d265567d0486e8677c9b8c526ad6
https://doi.org/10.1016/j.mcn.2016.10.001
https://doi.org/10.1016/j.mcn.2016.10.001