Brain proteome profiling implicates the complement and coagulation cascade in multiple system atrophy brain pathology

Autor: Rasmus Rydbirk, Ole Østergaard, Jonas Folke, Casper Hempel, Brian DellaValle, Thomas L. Andresen, Annemette Løkkegaard, Anne-Mette Hejl, Matthias Bode, Morten Blaabjerg, Mette Møller, Erik H. Danielsen, Lisette Salvesen, Charlotte C. Starhof, Sara Bech, Kristian Winge, Jørgen Rungby, Bente Pakkenberg, Tomasz Brudek, Jesper V. Olsen, Susana Aznar

Publikováno v: Rydbirk, R, Østergaard, O, Folke, J, Hempel, C, DellaValle, B, Andresen, T L, Løkkegaard, A, Hejl, A M, Bode, M, Blaabjerg, M, Møller, M, Danielsen, E H, Salvesen, L, Starhof, C C, Bech, S, Winge, K, Rungby, J, Pakkenberg, B, Brudek, T, Olsen, J V & Aznar, S 2022, ' Brain proteome profiling implicates the complement and coagulation cascade in multiple system atrophy brain pathology ', Cellular and Molecular Life Sciences, vol. 79, no. 6, 336 . https://doi.org/10.1007/s00018-022-04378-z

Background: Multiple system atrophy (MSA) is a rare, progressive, neurodegenerative disorder presenting glia pathology. Still, disease etiology and pathophysiology are unknown, but neuro-inflammation and vascular disruption may be contributing factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414588e6e93161d2374b6b53847171d7
https://pure.au.dk/portal/da/publications/brain-proteome-profiling-implicates-the-complement-and-coagulation-cascade-in-multiple-system-atrophy-brain-pathology(b8cd5ea5-42d8-44af-9892-0c9cb28de11d).html

Portrayal of a young woman in 16

Autor: Daniel, Kondziella, Sara, Bech

Publikováno v: Iranian Journal of Neurology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::037b3597782a70340c0d40e13141d8c2
https://pubmed.ncbi.nlm.nih.gov/31210905

Familial aggregation of Parkinson's disease in the Faroe Islands

Autor: Matthew J. Farrer, Maria Skaalum Petersen, Sara Bech, Jan O. Aasly, Ekaterina Nosova

Publikováno v: Movement Disorders. 30:538-544

The Faroe Islands are a geographic population isolated in the North Atlantic with a high prevalence of Parkinson's disease (PD). Although environmental risk factors are well described, the familial aggregation of PD on the Islands has yet to be explo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00064d3dfa9efab3e292bf0a5c6dd626
https://doi.org/10.1002/mds.26132

Cerebrospinal fluid α-synuclein in the differential diagnosis of parkinsonian syndromes

Autor: Sara Bech, Liliana Cp Montezinho, Niels Hh Heegaard, Lisette Salvesen, Kristian Winge, Julia T. Tanassi, Peter Lüttge Jensen

Publikováno v: Future Neurology. 9:525-532

ABSTRACT: Aim: To evaluate the diagnostic value of the level of α-synuclein, DJ-1, and Alzheimer's disease markers in the cerebrospinal fluid (CSF) in patients with parkinsonian syndromes. Materials & methods: We measured α-synuclein, DJ-1 and Alzh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb5f5f9a8136878a5198e6deced6b2a5
https://doi.org/10.2217/fnl.14.51

Novel mutation in ATP13A2 widens the spectrum of Kufor-Rakeb syndrome (PARK9)

Autor: Jørgen E. Nielsen, Lars Friberg, Lena E. Hjermind, Kirsten Svenstrup, Lars H. Pinborg, Lars Hansen, Hans Eiberg, Olsen Or, Sara Bech, Korbo L, Inge-Merete Nielsen

Publikováno v: Clinical Genetics. 82:256-263

Kufor-Rakeb syndrome (KRS) is a rare autosomal recessive inherited juvenile parkinsonian syndrome caused by mutations in ATP13A2. We describe six patients from a consanguineous Greenlandic Inuit family, homozygous for a novel frame-shift mutation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768cb9d378c97d7f144ac24508bc1587
https://doi.org/10.1111/j.1399-0004.2011.01745.x