Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sara B.-M. Whittaker"'
Autor:
Saima Rehman, Anna Katarina Antonovic, Ian E. McIntire, Huaixin Zheng, Leanne Cleaver, Maria Baczynska, Carlton O. Adams, Theo Portlock, Katherine Richardson, Rosie Shaw, Alain Oregioni, Giulia Mastroianni, Sara B-M. Whittaker, Geoff Kelly, Christian D. Lorenz, Arianna Fornili, Nicholas P. Cianciotto, James A. Garnett
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Bacterial adhesion is a fundamental process which enables colonisation of niche environments and is key for infection. However, in Legionella pneumophila, the causative agent of Legionnaires’ disease, these processes are not well understoo
Externí odkaz:
https://doaj.org/article/dc482835699a4915aefeb24d5457763d
Autor:
Daniel S Gutmans, Sara B-M Whittaker, Karishma Asiani, R Andrew Atkinson, Alain Oregioni, Mark Pfuhl
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0210352 (2019)
Nek2 is a dimeric serine/ threonine protein kinase that belongs to the family of NIMA-related kinases (Neks). Its N-terminal catalytic domain and its C-terminal regulatory region are bridged by a leucine zipper, which plays an important role in the a
Externí odkaz:
https://doaj.org/article/de49b37a53f24351ba84fd3a4ecaf817
Autor:
Ben, Dorgan, Yichao, Liu, Sunjun, Wang, Joseph, Aduse-Opoku, Sara B-M, Whittaker, Mark A J, Roberts, Christian D, Lorenz, Michael A, Curtis, James A, Garnett
Publikováno v:
Journal of Molecular Biology. 434:167871
Porphyromonas gingivalis is a gram-negative oral anaerobic pathogen and is one of the key causative agents of periodontitis. P. gingivalis utilises a range of virulence factors, including the cysteine protease RgpB, to drive pathogenesis and these ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d40b1dba27b46cc640fbfc6de776bee
https://doi.org/10.1016/j.jmb.2022.167871
https://doi.org/10.1016/j.jmb.2022.167871
Autor:
R. Andrew Atkinson, Daniel S. Gutmans, Karishma Asiani, Mark Pfuhl, Alain Oregioni, Sara B.-M. Whittaker
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2019, 14 (2), pp.e0210352. ⟨10.1371/journal.pone.0210352⟩
Gutmans, D S, Whittaker, S B-M, Asiani, K, Atkinson, R A, Oregioni, A & Pfuhl, M 2019, ' Controlling the dynamics of the Nek2 leucine zipper by engineering of "kinetic" disulphide bonds ', PLoS ONE, vol. 14, no. 2, e0210352, pp. e0210352 . https://doi.org/10.1371/journal.pone.0210352
PLoS ONE, Vol 14, Iss 2, p e0210352 (2019)
PLoS ONE, Public Library of Science, 2019, 14 (2), pp.e0210352. ⟨10.1371/journal.pone.0210352⟩
Gutmans, D S, Whittaker, S B-M, Asiani, K, Atkinson, R A, Oregioni, A & Pfuhl, M 2019, ' Controlling the dynamics of the Nek2 leucine zipper by engineering of "kinetic" disulphide bonds ', PLoS ONE, vol. 14, no. 2, e0210352, pp. e0210352 . https://doi.org/10.1371/journal.pone.0210352
PLoS ONE, Vol 14, Iss 2, p e0210352 (2019)
International audience; Nek2 is a dimeric serine/ threonine protein kinase that belongs to the family of NIMA-related kinases (Neks). Its N-terminal catalytic domain and its C-terminal regulatory region are bridged by a leucine zipper, which plays an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc17ac96fc0b9e25b6a00ca9843bd3ee
https://hal.archives-ouvertes.fr/hal-03027656/file/2019_Gutmans.pdf
https://hal.archives-ouvertes.fr/hal-03027656/file/2019_Gutmans.pdf
Autor:
Sara B.-M. Whittaker, Celso Eduardo Benedetti, Adriana Franco Paes Leme, Bruna Medeia Campos, João Alexandre Ribeiro Gonçalvez Barbosa, Carlos A. Pérez, Mário T. Murakami, Andre Luis Berteli Ambrosio, Maurício L. Sforça, Mariane Noronha Domingues, Tatiana de Arruda Campos Brasil de Souza, Ana Carolina de Matos Zeri
Publikováno v:
Plant Physiology. 162:1311-1323
The citrus (Citrus sinensis) cyclophilin CsCyp is a target of the Xanthomonas citri transcription activator-like effector PthA, required to elicit cankers on citrus. CsCyp binds the citrus thioredoxin CsTdx and the carboxyl-terminal domain of RNA pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6f8fe6b6887daae44393d45c19081c
https://doi.org/10.1104/pp.113.218339
https://doi.org/10.1104/pp.113.218339
Autor:
Rudolf Konrad Allemann, Rhiannon M. Evans, William M. Dawson, Matthew P. Crump, Sara B.-M. Whittaker, Stella M. Matthews, Ulrich L. Günther, Christopher Williams, E. Joel Loveridge
Publikováno v:
Biomolecular NMR Assignments. 7:61-64
Dihydrofolate reductase from the deep-sea bacterium Moritella profunda (MpDHFR) has been (13)C/(15)N isotopically labelled and purified. Here, we report the aliphatic (1)H, (13)C and (15)N resonance assignments of MpDHFR in complex with NADP(+) and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0e9049eb371bbc495548828cd5fa3f
https://doi.org/10.1007/s12104-012-9378-x
https://doi.org/10.1007/s12104-012-9378-x
Publikováno v:
Journal of Molecular Biology. 414:511-529
Previous work shows that Im9 folds in a two-state transition while its homologue Im7 folds in a three-state transition via an on-pathway kinetic intermediate state (KIS), with this difference being related to frustration in the structure of Im7. We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93d2d4be14c25aa643a0c04e49d6e00
https://doi.org/10.1016/j.jmb.2011.09.038
https://doi.org/10.1016/j.jmb.2011.09.038
Autor:
Maria J.P. van Dongen, Christian Ludwig, Paul J. A. Michiels, Ulrich L. Günther, Sara B.-M. Whittaker, Karen Atkins
Publikováno v:
Biomolecular NMR Assignments. 4:101-105
The orphan nuclear receptor Nurr1 has been implicated in a number of conditions including Parkinson's disease and Schizophrenia. As such, it is of interest to study its interactions with other proteins, possibly mediated by small molecules, consideri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f170eae22c59052951ca1b34f501d5
https://doi.org/10.1007/s12104-010-9210-4
https://doi.org/10.1007/s12104-010-9210-4
Publikováno v:
Biomolecular NMR Assignments. 3:215-218
The human AKAP13 protein contains DH and PH domains, which are responsible for its cell transforming activity. Despite its biomedical importance, the contribution of the PH domain to AKAP13 activity remains unclear and no three dimensional structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed613b42b6ff32187f15bf1c2497112e
https://doi.org/10.1007/s12104-009-9178-0
https://doi.org/10.1007/s12104-009-9178-0
Autor:
Christian Ludwig, Brian Schaffhausen, Tao Jiang, Sara B.-M. Whittaker, Konstantin Knoblich, Paul J. A. Michiels, Ulrich L. Günther
Publikováno v:
Biomolecular NMR Assignments. 3:119-123
Polyoma Large T antigen (PyLT) is a viral oncoprotein that targets cell proteins important for growth regulation. PyLT has two functional domains. Here we report (1)H, (15)N, (13)C backbone and (13)C beta assignments of 76% of the residues of the pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff8598f7bd743b41cc80f0502d28934
https://doi.org/10.1007/s12104-009-9155-7
https://doi.org/10.1007/s12104-009-9155-7