Výsledky vyhledávání - "Sara Anne Little"

Abstract P39: Pre-clinical evaluation of NEOS-223, an (S)-valine-thiazole derived peptidomimetic N-heterocycle, as an anticancer agent and P-glycoprotein inhibitor

Autor: Laxman Desai, Timothy Murphy, Sumathi Chittamuru, Roseanne Wexler, Andrew A. Taylor, Sara Anne Little

Publikováno v: Clinical Cancer Research. 27:P39-P39

The ability to control the proliferation and cell death by inhibiting specific target kinase offers the opportunity to apply targeted therapies in the treatment of cancer. It has been found that (S)-valine-thiazole-derived compounds such as NEOS-223

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e23dbf6ceb06c996a7c714f9dbb89bd
https://doi.org/10.1158/1557-3265.covid-19-21-p39

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In vitro characterization and in vivo efficacy of NEOS-518, a novel isoquinoline embedded amino oxazole, that demonstrates CDK-1,2, 3, and 9 inhibition

Autor: Roseanne Wexler, Sara Anne Little, Laxman Desai, Timothy Murphy, Sumathi Chittamuru

Publikováno v: Journal of Clinical Oncology. 36:e14509-e14509

e14509Background: Cyclin dependent kinases (CDK) play a vital role in cell cycling and proliferation. Altered expression of these kinases in malignant cells results in deregulation of cell cycle ac...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b25024ede990a779cbe3210a21d9866
https://doi.org/10.1200/jco.2018.36.15_suppl.e14509

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