Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sara Al-Sweidi"'
Autor:
Andrée-Anne Poirier, Mélissa Côté, Hend Jarras, Nadhir Litim, Jérôme Lamontagne-Proulx, Sara Al-Sweidi, Marc Morissette, Asmaa Lachhab, Martin Pelletier, Thérèse Di Paolo, Denis Soulet
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Gastrointestinal disorders in Parkinson’s disease (PD) have been associated with neuronal alteration in the plexus of the gut. We previously demonstrated the immunomodulatory effect of female hormones to treat enteric neurodegeneration in the 1-met
Externí odkaz:
https://doaj.org/article/c8da65148103495c9b9e6e7073e55f5d
Autor:
Edith Miville-Godbout, Mélanie Bourque, Marc Morissette, Sara Al-Sweidi, Tara Smith, Asuka Mochizuki, Vijitha Senanayake, Dushmanthi Jayasinghe, Li Wang, Dayan Goodenowe, Thérèse Di Paolo
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151020 (2016)
Plasmalogens are a class of glycerophospholipids shown to play critical roles in membrane structure and function. Decreased plasmalogens are reported in the brain and blood of Parkinson's disease (PD) patients. The present study investigated the hypo
Externí odkaz:
https://doaj.org/article/462831a4dc6d4259a98f5073c8401fad
Autor:
Shawn Ritchie, Dushmanthi Jayasinghe, Marc Morissette, Mélanie Bourque, Edith Miville-Godbout, Thérèse Di Paolo, Sara Al-Sweidi, Tara C. Smith
Publikováno v:
Brain Research. 1674:70-76
Ethanolamine plasmalogens (PlsEtn) are a class of glycerophospholipids characterized by a vinyl-ether bond at the sn-1 position that play an important role in the structure and function of membranes. Previous reports have suggested a link between red
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 161:84-91
Glutamate is the most important brain excitatory neurotransmitter and glutamate overactivity is well documented in Parkinson's disease (PD). Metabotropic glutamate (mGlu) receptors are reported to interact with membrane estrogen receptors (ERs) and m
Publikováno v:
Neuropharmacology. 97:86-94
Finasteride and Dutasteride are 5α-reductase inhibitors used in the clinic to treat endocrine conditions and were recently found to modulate brain dopamine (DA) neurotransmission and motor behavior. We investigated if Finasteride and Dutasteride hav
Autor:
Sara Al Sweidi, Roberto Cosimo Melcangi, Marc Morissette, Donatella Caruso, Thérèse Di Paolo, Mélanie Bourque
Publikováno v:
Neuroendocrinology. 103:300-314
Background: Numerous studies have reported on the neuroprotective activity of estradiol, whereas the effect of the other ovarian steroid, progesterone, is much less documented. Methods: This study sought to investigate neuroprotection with a low dose
Autor:
Thérèse Di Paolo, Vijitha Senanayake, Asuka Mochizuki, Dushmanthi Jayasinghe, Li Wang, Edith Miville-Godbout, Dayan B. Goodenowe, Mélanie Bourque, Tara C. Smith, Sara Al-Sweidi, Marc Morissette
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151020 (2016)
PLoS ONE
PLoS ONE
Plasmalogens are a class of glycerophospholipids shown to play critical roles in membrane structure and function. Decreased plasmalogens are reported in the brain and blood of Parkinson’s disease (PD) patients. The present study investigated the hy
Publikováno v:
Journal of Neuroendocrinology. 24:1375-1385
Parkinson's disease (PD) is characterised by the loss of nigrostriatal dopamine (DA) neurones and glutamate overactivity. There is substantial evidence to suggest that oestrogens prevent or delay the disease. 17β-oestradiol has neuroprotective effec
Publikováno v:
Neuropharmacology. 61:583-591
17β-estradiol is well known to have neuroprotective effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. We investigated the neuroprotective contribution of estrogen receptors (ERα and ERβ) against MPTP toxicity by
Publikováno v:
Molecular and cellular endocrinology. 290(1-2)
A higher prevalence and incidence of Parkinson disease (PD) is observed in men and beneficial motor effects of estrogens are observed in parkinsonian women. Lesion of the dopamine (DA) nigrostriatal pathway in animals with 1-methyl 4-phenyl-1,2,3,6 t