Výsledky vyhledávání - "Sara Abdelghany"

A computer-aided approach to identify novel Leishmania major protein disulfide isomerase inhibitors for treatment of leishmaniasis

Autor: Giuseppe Romeo, Noureddine Ben Khalaf, Ivy Hurwitz, Douglas J Perkins, Loredana Salerno, Peter Sedillo, Susie Pham, Jessica Gonzales, Dahmani M. Fathallah, Sebastiano Intagliata, Valeria Pittalà, Sara Abdelghany

Publikováno v: Journal of Computer-Aided Molecular Design. 35:297-314

Leishmaniasis is an infectious disease caused by parasites of the genus Leishmania and transmitted by the bite of a sand fly. To date, most available drugs for treatment are toxic and beyond the economic means of those affected by the disease. Protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5f9eacec83e410b0f86a963fe4b14f
https://doi.org/10.1007/s10822-021-00374-w

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Micellar formulations of Crizotinib and Dasatinib in the management of glioblastoma multiforme

Autor: Anfal Jasim, Khaled Greish, Sebastien Taurin, Hayley Nehoff, Sara Abdelghany, Neha N. Parayath, Ali Alkhateeb

Publikováno v: Journal of Drug Targeting. 26:692-708

Glioblastoma multiforme (GBM) defies the currently practiced management of radiotherapy, chemotherapy and surgery and hence, it is associated with a high fatality rate with a median survival of 14.6 months. In our previous work investigating differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f54fbd1921cdc2b349042300bc05a9b
https://doi.org/10.1080/1061186x.2017.1419357

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Sildenafil citrate improves the delivery and anticancer activity of doxorubicin formulations in a mouse model of breast cancer

Autor: Khaled Greish, Sara Abdelghany, Nanitha Rachel, Houman Alimoradi, Moiz Bakhiet, Ahmed Alsaie, Maryam Fateel

Publikováno v: Journal of Drug Targeting. 26:610-615

Sildenafil is an approved drug for the treatment of erectile dysfunction. The drug exerts its action through the relaxation of smooth muscles and the modulation of vascular endothelial permeability. In this work, we tested whether the aforementioned

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16970015e042ed4f69f37965b65a0257
https://doi.org/10.1080/1061186x.2017.1405427

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Current Update on the Role of Enhanced Permeability and Retention Effect in Cancer Nanomedicine

Autor: Khaled Greish, Anfal Jasim, Sara Abdelghany

In the 1980s Maeda and his colleagues discover a unique phenomenon called the enhanced permeability and retention (EPR) effect. This phenomenon describes the facilitated extravasation of macromolecular drugs more selectively at tumor tissues due to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af063c203314b7f3bc9fb2676bb45bc3
https://doi.org/10.1016/b978-0-12-809717-5.00002-6

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