Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Sara Abdelfatah"'
Autor:
Ejlal A. Omer, Sara Abdelfatah, Max Riedl, Christian Meesters, Andreas Hildebrandt, Thomas Efferth
Publikováno v:
Molecules, Vol 28, Iss 3, p 988 (2023)
During the past three decades, humans have been confronted with different new coronavirus outbreaks. Since the end of the year 2019, COVID-19 threatens the world as a rapidly spreading infectious disease. For this work, we targeted the non-structural
Externí odkaz:
https://doaj.org/article/e1e457a67b0f4cd8981dd62f217541d6
Publikováno v:
Pharmaceuticals, Vol 15, Iss 11, p 1345 (2022)
Background: This study aimed to assess the effect of a fixed combination of Red Ginseng and Red Sage (RG–RS) on the gene expression of neuronal cells to evaluate the potential impacts on cellular functions and predict its relevance in the treatment
Externí odkaz:
https://doaj.org/article/c83e6da09c9c4b59b0b25bd537ea6756
Autor:
Sara Abdelfatah, Angela Berg, Qi Huang, Li Jun Yang, Sami Hamdoun, Anette Klinger, Henry J. Greten, Edmond Fleischer, Thorsten Berg, Vincent K.W. Wong, Thomas Efferth
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 1021-1034 (2019)
Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Po
Externí odkaz:
https://doaj.org/article/5d92f179f9394a6dad8794c0b9488b8b
Publikováno v:
Journal of Advanced Research, Vol 16, Iss , Pp 145-156 (2019)
Polo-like kinase 1 (PLK1), a member of the Polo-like kinase family, plays an important regulatory role in mitosis and cell cycle progression. PLK1 overexpression is correlated with tumourigenesis and poor prognosis in cancer patients. Therefore, the
Externí odkaz:
https://doaj.org/article/e992528721764425979602b0ba4ad0a3
Autor:
Alexandra Pohler, Sara Abdelfatah, Max Riedl, Christian Meesters, Andreas Hildebrandt, Thomas Efferth
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1046 (2022)
The nucleocapsid protein (NP) is one of the main proteins out of four structural proteins of coronaviruses including the severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, discovered in 2019. NP packages the viral RNA during virus assembly
Externí odkaz:
https://doaj.org/article/0f79e09133784608b02fb6931fb617bd
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 308 (2022)
The main protease (Mpro or 3CLpro) in coronaviruses represents a promising specific drug target as it is essential for the cleavage of the virus polypeptide and has a unique cleavage site that does not exist in human host proteases. In this study, we
Externí odkaz:
https://doaj.org/article/c419b2b0898e4a779c051d31eaeb3ec2
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 999 (2021)
Numerous in vitro studies on isolated cells have been conducted to uncover the molecular mechanisms of action of Panax ginseng Meyer root extracts and purified ginsenosides. However, the concentrations of ginsenosides and the extracts used in these s
Externí odkaz:
https://doaj.org/article/d8875e042bc14bad8f35f2b8e3423977
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 1010 (2021)
Panax ginseng C.A.Mey. is an adaptogenic plant traditionally used to enhance mental and physical capacities in cases of weakness, exhaustion, tiredness, or loss of concentration, and during recovery. According to ancient records, red ginseng root pre
Externí odkaz:
https://doaj.org/article/636cba1d7f35400ba29923f376f6d1a4
Autor:
Lisa Gruber, Sara Abdelfatah, Tony Fröhlich, Christoph Reiter, Volker Klein, Svetlana B. Tsogoeva, Thomas Efferth
Publikováno v:
Molecules, Vol 23, Iss 4, p 841 (2018)
Two major obstacles for successful cancer treatment are the toxicity of cytostatics and the development of drug resistance in cancer cells during chemotherapy. Acquired or intrinsic drug resistance is responsible for almost 90% of treatment failure.
Externí odkaz:
https://doaj.org/article/36f51b2e501b4048a2a54cbdead2d5c1
Publikováno v:
Medicines, Vol 3, Iss 4, p 30 (2016)
Background: Alzheimer’s disease is one of the most prevalent dementias in the elderly population with increasing numbers of patients. One pivotal hallmark of this disorder is the deposition of protein aggregates stemming from neurotoxic amyloid-bet
Externí odkaz:
https://doaj.org/article/9030a7f9e8764db699b2a8ce25133334