Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders

Autor: Thibaud Dieudonné, Sara Abad Herrera, Michelle Juknaviciute Laursen, Maylis Lejeune, Charlott Stock, Kahina Slimani, Christine Jaxel, Joseph A Lyons, Cédric Montigny, Thomas Günther Pomorski, Poul Nissen, Guillaume Lenoir

Publikováno v: eLife, Vol 11 (2022)

P4-ATPases flip lipids from the exoplasmic to the cytosolic leaflet, thus maintaining lipid asymmetry in eukaryotic cell membranes. Mutations in several human P4-ATPase genes are associated with severe diseases, for example in ATP8B1 causing progress

Externí odkaz: https://doaj.org/article/3aef36513b5f4d23abe9a3bff757fc35

Purification and characterisation of the yeast plasma membrane ATP binding cassette transporter Pdr11p.

Autor: Katrine Rude Laub, Magdalena Marek, Lyubomir Dimitrov Stanchev, Sara Abad Herrera, Tamara Kanashova, Adèle Bourmaud, Gunnar Dittmar, Thomas Günther Pomorski

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0184236 (2017)

The ATP binding cassette (ABC) transporters Pdr11p and its paralog Aus1p are expressed under anaerobic growth conditions at the plasma membrane of the yeast Saccharomyces cerevisiae and are required for sterol uptake. However, the precise mechanism b

Externí odkaz: https://doaj.org/article/e5215dc6bf7040e284cf948303dcf867

Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders

Autor: Thibaud Dieudonné, Kahina Slimani, Poul Nissen, Charlott Stock, Michelle Juknaviciute Laursen, Cédric Montigny, Christine Jaxel, Thomas Günther Pomorski, Joseph A. Lyons, Sara Abad Herrera, Guillaume Lenoir, Maylis Lejeune

P-type ATPases from the P4 subfamily (P4-ATPases) are primary active transporters that maintain lipid asymmetry in eukaryotic cell membranes by flipping lipids from the exoplasmic to the cytosolic leaflet. Mutations in several human P4-ATPase genes a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01f0dba3aae680201131f68c05594c27
https://doi.org/10.1101/2021.11.03.467174

Purification and characterisation of the yeast plasma membrane ATP binding cassette transporter Pdr11p

Autor: Adèle Bourmaud, Magdalena Marek, Gunnar Dittmar, Katrine Rude Laub, Sara Abad Herrera, Thomas Günther Pomorski, Tamara Kanashova, Lyubomir Dimitrov Stanchev

Publikováno v: PLoS One, vol. 12, no. 9, pp. e0184236
Laub, K R, Marek, M, Stanchev, L D, Herrera, S A, Kanashova, T, Bourmaud, A, Dittmar, G & Pomorski, T G 2017, ' Purification and characterisation of the yeast plasma membrane ATP binding cassette transporter Pdr11p ', PLOS ONE, vol. 12, no. 9, e0184236 . https://doi.org/10.1371/journal.pone.0184236
PLoS ONE, Vol 12, Iss 9, p e0184236 (2017)
PLoS ONE

The ATP binding cassette (ABC) transporters Pdr11p and its paralog Aus1p are expressed under anaerobic growth conditions at the plasma membrane of the yeast \(\textit {Saccharomyces cerevisiae}\) and are required for sterol uptake. However, the preci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313d2408fd024c2fd96d1235208593af
https://hss-opus.ub.ruhr-uni-bochum.de/opus4/files/7366/PomorskiThomasGuenther.pdf