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pro vyhledávání: '"Sara A. Rafice"'
Autor:
Lila Ghamsari, Nishma Chauhan, Sara A. Rafice, Emma Lloyd Raven, Igor Efimov, Jaswir Basran, Myles R. Cheesman
Publikováno v:
Biochemistry. 47:4752-4760
The family of heme dioxygenases, as exemplified by indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase, catalyzes the oxidative cleavage of L-tryptophan to N-formylkynurenine. Here, we describe a bacterial expression system for human tryptopha
Autor:
Jaswir Basran, Nishma Chauhan, Sandeep Handa, Igor Efimov, Christopher G. Mowat, Sara A. Rafice, Peter C. E. Moody, Emma Lloyd Raven, Elizabeth S. Millett
Publikováno v:
The FEBS journal. 279(24)
Indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase catalyze the O(2) -dependent oxidation of l-tryptophan to N-formylkynurenine. Both are heme-containing enzymes, with a proximal histidine ligand, as found in the globins and peroxidases. From
Publikováno v:
Biochemical Society transactions. 37(Pt 2)
The family of haem dioxygenases catalyse the initial oxidative cleavage of L-tryptophan to N-formylkynurenine, which is the first, rate-limiting, step in the L-kynurenine pathway. In the present paper, we discuss and compare structure and function ac
Autor:
Nishma Chauhan, Michael R. F. Lee, Igor Efimov, Emma Lloyd Raven, Jaswir Basran, Sara A. Rafice, Stephen K Chapman, Graham Eaton, Paul R. Jenkins, Sarah J. Thackray, Christopher G. Mowat
Publikováno v:
Journal of the American Chemical Society. 131:4186-4187
Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are heme enzymes that catalyze the O(2)-dependent oxidation of L-tryptophan to N-formyl-kynurenine. Previous proposals for the mechanism of this reaction have suggested that depro
Autor:
Sara A. Rafice
Publikováno v:
Physics World. 21:18-18
In December the UK's Science and Technology Facilities Council (STFC) announced an £80m shortfall in research funding for physics and astrophysics over the next three years (January p7). This led to the closure of the European Incoherent Scatter (EI