Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sara A. Mathie"'
Autor:
Raquel Granell, John A Curtin, Sadia Haider, Negusse Tadesse Kitaba, Sara A Mathie, Lisa G Gregory, Laura L Yates, Mauro Tutino, Jenny Hankinson, Mauro Perretti, Judith M Vonk, Hasan S Arshad, Paul Cullinan, Sara Fontanella, Graham C Roberts, Gerard H Koppelman, Angela Simpson, Steve W Turner, Clare S Murray, Clare M Lloyd, John W Holloway, Adnan Custovic, on behalf of UNICORN and Breathing Together investigators
Publikováno v:
eLife, Vol 12 (2023)
Background: Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of ‘doctor-diagnosed asthma’, thereby diluting genetic signals by not considering asth
Externí odkaz:
https://doaj.org/article/ef3714c583a24ddeb37692801c1faf88
Autor:
Annette Zehrer, Ashleigh Hemmings, Erinke van Grinsven, Sara A. Mathie, Tariq E. Khoyratty, Lihui Wang, Zhichao Ai, Nicola Willemsen, Irina A. Udalova, Iván Ballesteros, Andrés Hidalgo, Hayley L. Eames, Barbara Walzog, Valentin von Werz, Sandra Martín-Salamanca
Publikováno v:
Nature immunology. 22(9)
Neutrophils display distinct gene expression patters depending on their developmental stage, activation state and tissue microenvironment. To determine the transcription factor networks that shape these responses in a mouse model, we integrated trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a7397b425446972f81326c807dc32f
https://pubmed.ncbi.nlm.nih.gov/34363039
https://pubmed.ncbi.nlm.nih.gov/34363039
Autor:
Clare M. Lloyd, David Saliba, Sara A. Mathie, Miriam Weiss, Adam J. Byrne, Simone A. Walker, Irina A. Udalova, Hayley L. Eames
Publikováno v:
Mucosal immunology
Interferon regulatory factor 5 (IRF5) is a key transcription factor involved in the control of the expression of pro-inflammatory cytokine and responses to infection, however its role in regulating pulmonary immune responses to allergen is unknown. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487f5661524fc8b9eecbf6a7eedcbebe
http://europepmc.org/articles/PMC5266556
http://europepmc.org/articles/PMC5266556
Autor:
Malcolm J. W. Sim, Janet Stowell, Jiten Manji, Catherine J. Reynolds, Rosemary J. Boyton, Xiaoming Cheng, Kathryn J. Quigley, Katherine Choy, Sundas Tahir, Tracey Pollard, Sara A. Mathie, Simone A. Walker, Fiyyaz Ahmed-Jushuf, Daniel M. Altmann, Apurva Suresh, Khizr Nawab
IL-8-dependent inflammation is a hallmark of host lung innate immunity to bacterial pathogens, yet in many human lung diseases, including chronic obstructive pulmonary disease, bronchiectasis, and pulmonary fibrosis, there are progressive, irreversib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74400730cd459279dce3b6d255e40b9
http://hdl.handle.net/10044/1/60795
http://hdl.handle.net/10044/1/60795
Publikováno v:
Thorax. 70:1189-1196
Macrophages are the most numerous immune-cells present in the lung environment under homoeostatic conditions and are ideally positioned to dictate the innate defence of the airways. Pulmonary macrophage populations are heterogeneous and demonstrate r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11a8f3efb75d550c04204b836d30a01
https://doi.org/10.1136/thoraxjnl-2015-207020
https://doi.org/10.1136/thoraxjnl-2015-207020
Autor:
Clare M. Lloyd, Sara A. Mathie, Sophie Pegorier, Simone A. Walker, Carla P. Jones, Lisa G. Gregory
Publikováno v:
American journal of respiratory and critical care medicine. 182(2)
Airway hyperreactivity and remodeling are characteristic features of asthma. Interactions between the airway epithelium and environmental allergens are believed to be important in driving development of pathology, particularly because altered epithel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dabd6e1e716d2c3712aa3f183ec756f
https://pubmed.ncbi.nlm.nih.gov/20339149
https://pubmed.ncbi.nlm.nih.gov/20339149
Autor:
Sara A. Mathie, Clare M. Lloyd, Jenna R. Murdoch, Christopher P. Thomas, Benjamin Causton, Lisa G. Gregory, F. M. Priest, Valerie B. O'Donnell, Diana Quint
Background Inhaled house dust mite (HDM) results in T-helper (TH) 2 type pathology in unsensitized mice, in conjunction with airway hyperreactivity and airway remodelling. However, the pulmonary cytokine and chemokine profile has not been reported. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed5c110b76e723b32d8ca2facb2efe8
https://europepmc.org/articles/PMC3385347/
https://europepmc.org/articles/PMC3385347/
Publikováno v:
American journal of respiratory cell and molecular biology. 41(3)
Asthma frequently commences in early life during airway and immune development and exposure to new environmental challenges. Endobronchial biopsies from children with asthma are abnormal, and lung function is maximally reduced by 6 years of age. As l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed99615960527eaba3d91f9f75601ee0
https://pubmed.ncbi.nlm.nih.gov/19151316
https://pubmed.ncbi.nlm.nih.gov/19151316
Autor:
Sara A. Mathie, Hongwei Wang, Tracy Hussell, Clare M. Lloyd, Peter J. M. Openshaw, Lorna Edwards, Sophie Tourdot, Jürgen Schwarze
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 38(6)
Summary Background The mechanisms underlying exacerbation of asthma induced by respiratory syncytial virus (RSV) infection have been extensively studied in human and animal models. However, most of these studies focused on acute inflammation and litt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3039a4e6dea5c155087c1099a870da82
https://pubmed.ncbi.nlm.nih.gov/18498543
https://pubmed.ncbi.nlm.nih.gov/18498543
Autor:
Clare M. Lloyd, Timothy Oates, Sara A. Mathie, Cara Bossley, Stephen Lui, Simone A. Walker, Andrew Bush, Sejal Saglani, Laura Denney, Rebekah Sherburn, Nicola Ullmann, Gaynor A. Campbell
Publikováno v:
Journal of Allergy and Clinical Immunology. 132:676-685.e13
Background T H 2 cytokines are not responsible for the ongoing symptoms and pathology in children with severe therapy-resistant asthma (STRA). IL-33 induces airway hyperresponsiveness, but its role in airway remodeling and steroid resistance is unkno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bc0f0f9098eea2e71ded76f602b8b82
https://doi.org/10.1016/j.jaci.2013.04.012
https://doi.org/10.1016/j.jaci.2013.04.012