Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sara A. Litwak"'
Autor:
Pablo J. Enriori, Weiyi Chen, Maria C. Garcia-Rudaz, Bernadette E. Grayson, Anne E. Evans, Sarah M. Comstock, Ursel Gebhardt, Hermann L. Müller, Thomas Reinehr, Belinda A. Henry, Russell D. Brown, Clinton R. Bruce, Stephanie E. Simonds, Sara A. Litwak, Sean L. McGee, Serge Luquet, Sarah Martinez, Martin Jastroch, Matthias H. Tschöp, Matthew J. Watt, Iain J. Clarke, Christian L. Roth, Kevin L. Grove, Michael A. Cowley
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 807-822 (2016)
Objective: Central melanocortin pathways are well-established regulators of energy balance. However, scant data exist about the role of systemic melanocortin peptides. We set out to determine if peripheral α-melanocyte stimulating hormone (α-MSH) p
Externí odkaz:
https://doaj.org/article/6eebea40ad004d3084746b4f5118b1a3
Autor:
Sara A. Litwak, Jibran A. Wali, Evan G. Pappas, Hamdi Saadi, William J. Stanley, L. Chitra Varanasi, Thomas W. H. Kay, Helen E. Thomas, Esteban N. Gurzov
Publikováno v:
Journal of Diabetes Research, Vol 2015 (2015)
Pancreatic β-cell loss induced by saturated free fatty acids (FFAs) is believed to contribute to type 2 diabetes. Previous studies have shown induction of endoplasmic reticulum (ER) stress, increased ubiquitinated proteins, and deregulation of the B
Externí odkaz:
https://doaj.org/article/cc42862cb1e94bc789cf5a2f5e4bdf7c
Autor:
Esteban Nicolas Gurzov, William J Stanley, Maria Eriksson, Peter Thorn, Ulf Ahlgren, Yan Yun, Sara A Litwak
Publikováno v:
Molecular Pharmaceutics
Molecular pharmaceutics
Molecular pharmaceutics
Type 1 diabetes develops in childhood and adolescence, with peak incidence in the early teenage years. There is an urgent need for an accurate method to detect insulin-producing β-cells in patients that is not affected by alterations in β-cell func
Autor:
Lokman Pang, Decio L. Eizirik, Jean Valéry Turatsinze, Kim Loh, Mariana Igoillo-Esteve, Esteban Nicolas Gurzov, William J Stanley, Daniel J. Gough, Eric Trepo, Christophe Moreno, Sara A Litwak, Arpeeta Sharma, Sandra Galic, Helen E. Thomas, Judy B. de Haan
Publikováno v:
Diabetes. 66:2973-2986
The members of the BCL-2 family are crucial regulators of the mitochondrial pathway of apoptosis in normal physiology and disease. Besides their role in cell death, BCL-2 proteins have been implicated in the regulation of mitochondrial oxidative phos
Autor:
Feng Ding, Pengyu Chen, Praveen Nedumpully-Govindan, Emily H. Pilkington, William J Stanley, Esteban Nicolas Gurzov, Sara A Litwak, Pu Chun Ke, Thomas P. Davis
Publikováno v:
Physical Chemistry Chemical Physics. 18:94-100
Human islet amyloid polypeptide (hIAPP or amylin) aggregation is directly associated with pancreatic β-cell death and subsequent insulin deficiency in type 2 diabetes (T2D). Since no cure is currently available for T2D, it is of great benefit to dev
Autor:
Martin Jastroch, Pablo J. Enriori, Anne E Evans, Christian L. Roth, Russell D Brown, Sara A. Litwak, Belinda A. Henry, Stephanie E. Simonds, Sarah M. Comstock, Serge Luquet, Maria Cecilia Garcia-Rudaz, Bernadette E. Grayson, Ursel Gebhardt, Sean L. McGee, Matthew J. Watt, Kevin L. Grove, Clinton R. Bruce, Sarah Martinez, Iain J. Clarke, Matthias H. Tschöp, Michael A. Cowley, Thomas Reinehr, Hermann L. Müller, Weiyi Chen
Publikováno v:
Molecular Metabolism
Mol. Metab. 5, 807-822 (2016)
Molecular Metabolism, Vol 5, Iss 10, Pp 807-822 (2016)
Mol. Metab. 5, 807-822 (2016)
Molecular Metabolism, Vol 5, Iss 10, Pp 807-822 (2016)
Objective Central melanocortin pathways are well-established regulators of energy balance. However, scant data exist about the role of systemic melanocortin peptides. We set out to determine if peripheral α-melanocyte stimulating hormone (α-MSH) pl
Autor:
Thomas P. Davis, William J Stanley, Emily H. Pilkington, Aleksandr Kakinen, Pu Chun Ke, Esteban Nicolas Gurzov, Sara A Litwak
Publikováno v:
Scientific Reports
Scientific reports, 6
Scientific reports, 6
Aggregation of human islet amyloid polypeptide (hIAPP) into fibrils and plaques is associated with pancreatic β-cell loss in type 2 diabetes (T2D). However, due to the rapidness of hIAPP conversion in aqueous phase, exactly which hIAPP species is re
Autor:
Pablo J. Enriori, Cathrine Laustrup Møller, Kirsten Raun, Rasmus Kjøbsted, Thomas E. Jensen, Jørgen F. P. Wojtaszewski, Birgitte Schjellerup Wulff, Cecilia Garcia-Rudaz, Michael A. Cowley, Sara A. Litwak
Publikováno v:
PLoS ONE
Møller, C L, Kjøbsted, R, Enriori, P J, Jensen, T E, Garcia-Rudaz, C, Litwak, S A, Raun, K, Wojtaszewski, J, Wulff, B S & Cowley, M A 2016, ' α-MSH stimulates glucose uptake in mouse muscle and phosphorylates Rab-GTPase-activating protein TBC1D1 independently of AMPK ', P L o S One, vol. 11, no. 7, e0157027 . https://doi.org/10.1371/journal.pone.0157027, https://doi.org/10.1371/journal.pone.0161047
PLoS ONE, Vol 11, Iss 7, p e0157027 (2016)
Møller, C L, Kjøbsted, R, Enriori, P J, Jensen, T E, Garcia-Rudaz, C, Litwak, S A, Raun, K, Wojtaszewski, J, Wulff, B S & Cowley, M A 2016, ' α-MSH stimulates glucose uptake in mouse muscle and phosphorylates Rab-GTPase-activating protein TBC1D1 independently of AMPK ', P L o S One, vol. 11, no. 7, e0157027 . https://doi.org/10.1371/journal.pone.0157027, https://doi.org/10.1371/journal.pone.0161047
PLoS ONE, Vol 11, Iss 7, p e0157027 (2016)
The melanocortin system includes five G-protein coupled receptors (family A) defined as MC1R-MC5R, which are stimulated by endogenous agonists derived from proopiomelanocortin (POMC). The melanocortin system has been intensely studied for its central
Autor:
Sara A Litwak, Kim Loh, Andreas Strasser, Esteban Nicolas Gurzov, Helen E. Thomas, Jibran A Wali, Claudia Selck, William J Stanley, Evan G Pappas
Publikováno v:
Scientific Reports
Scientific reports, 6
Scientific reports, 6
BCL-2 proteins have been implicated in the control of glucose homeostasis and metabolism in different cell types. Thus, the aim of this study was to determine the role of the pro-apoptotic BH3-only protein, p53-upregulated-modulator-of-apoptosis (PUM
Autor:
Thomas P. Davis, William J Stanley, Pu Chun Ke, Eric Hanssen, Aleksandr Kakinen, Sara A Litwak, Esteban Nicolas Gurzov, Pengyu Chen, Emily H. Pilkington, Feng Ding, Bo Wang
Publikováno v:
Small (Weinheim an der Bergstrasse, Germany). 12(12)
Human islet amyloid polypeptide (hIAPP, or amylin) forms amyloid deposits in the islets of Langerhans, a phenomenon that is associated with type-2 diabetes impacting millions of people worldwide. Accordingly, strategies against hIAPP aggregation are