Zobrazeno 1 - 10
of 244
pro vyhledávání: '"Sara A. Lewis"'
Autor:
Sara A. Lewis, Andrew Ruttenberg, Tuğçe Iyiyol, Nahyun Kong, Sheng Chih Jin, Michael C. Kruer
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105229- (2024)
Summary: Cerebral palsy (CP) has historically been attributed to acquired insults, but emerging research suggests that genetic variations are also important causes of CP. While microarray and whole-exome sequencing based studies have been the primary
Externí odkaz:
https://doaj.org/article/6f7984c072f1402ab02a3da0e5627c09
Autor:
Alexandra Santana Almansa, Dustin L. Gable, Zoë Frazier, Abigail Sveden, Aisling Quinlan, Maya Chopra, Sara A. Lewis, Michael Kruer, Annapurna Poduri, Siddharth Srivastava
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 2, Pp 251-262 (2024)
Abstract Objective Evaluation of the clinical utility of a genetic diagnosis in CP remains limited. We aimed to characterize the clinical utility of a genetic diagnosis by exome sequencing (ES) in patients with CP and related motor disorders. Methods
Externí odkaz:
https://doaj.org/article/178ffed6ae024256808885642165fd18
Autor:
Sara A. Lewis, Sheetal Shetty, Sean Gamble, Jennifer Heim, Ningning Zhao, Gideon Stitt, Matthew Pankratz, Tara Mangum, Iris Marku, Robert B. Rosenberg, Angus A. Wilfong, Michael C. Fahey, Sukhan Kim, Scott J. Myers, Brian Appavu, Michael C. Kruer
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-5 (2023)
Abstract Background Mutations in the NMDA receptor are known to disrupt glutamatergic signaling crucial for early neurodevelopment, often leading to severe global developmental delay/intellectual disability, epileptic encephalopathy, and cerebral pal
Externí odkaz:
https://doaj.org/article/5f38822c243b44708b9a5294b17175e5
Autor:
Sara A. Lewis, Somayeh Bakhtiari, Jacob Forstrom, Allan Bayat, Frédéric Bilan, Gwenaël Le Guyader, Ebba Alkhunaizi, Hilary Vernon, Sergio R. Padilla-Lopez, Michael C. Kruer
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/b5bc83387ee645bd900fb0386a2ee975
Autor:
Sara A. Lewis, Sheetal Shetty, Bryce A. Wilson, Aris J. Huang, Sheng Chih Jin, Hayley Smithers-Sheedy, Michael C. Fahey, Michael C. Kruer
Publikováno v:
Frontiers in Neurology, Vol 11 (2021)
Cohort-based whole exome and whole genome sequencing and copy number variant (CNV) studies have identified genetic etiologies for a sizable proportion of patients with cerebral palsy (CP). These findings indicate that genetic mutations collectively c
Externí odkaz:
https://doaj.org/article/2e240e5387c94a3bbae0a2882004e53d
Autor:
Ponni V. Perumalswami, Brooke Wyatt, Chip A. Bowman, Krupa Patel, Anna Mageras, Sara C. Lewis, Andrea D. Branch
Publikováno v:
Cancer Medicine, Vol 11, Iss 9, Pp 1995-2005 (2022)
Abstract Background Hepatocellular carcinoma (HCC) incidence and mortality vary by race/ethnicity and both are higher in Black patients than in Whites. For HCC surveillance, all cirrhotic patients are advised to undergo lifelong twice‐annual abdomi
Externí odkaz:
https://doaj.org/article/0863558d68664f3a9dabb19d0848a245
Autor:
Avalon C. S. Owens, Sara M. Lewis
Publikováno v:
Royal Society Open Science, Vol 9, Iss 8 (2022)
Anthropogenic light pollution is a novel environmental disruption that affects the movement, foraging and mating behaviour of nocturnal animals. Most of these effects are sublethal, and their net impact on reproductive fitness and population persiste
Externí odkaz:
https://doaj.org/article/5fb7b7f89d9c4e73b0ce155ad0b3d07d
Autor:
Sara E. Lewis
Publikováno v:
Journal of Global Buddhism, Vol 22, Iss 1 (2021)
Externí odkaz:
https://doaj.org/article/9d317b5e152147c7bc86c2a35c5eb755
Autor:
Sibile Pardue, Gopi K. Kolluru, Xinggui Shen, Sara E. Lewis, Courtney B. Saffle, Eric E. Kelley, Christopher G. Kevil
Publikováno v:
Redox Biology, Vol 34, Iss , Pp 101447- (2020)
Cardiovascular disease is the leading cause of death and disability worldwide with increased oxidative stress and reduced NO bioavailability serving as key risk factors. For decades, elevation in protein abundance and enzymatic activity of xanthine o
Externí odkaz:
https://doaj.org/article/d18ee3c620724710a536a1646f126159
Autor:
Ashley E. Russell, Sujung Jun, Saumyendra Sarkar, Werner J. Geldenhuys, Sara E. Lewis, Stephanie L. Rellick, James W. Simpkins
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Extracellular vesicles (EVs) are small, membrane-bound nanoparticles released from most, if not all cells, and can carry functionally active cargo (proteins, nucleic acids) which can be taken up by neighboring cells and mediate physiologically releva
Externí odkaz:
https://doaj.org/article/feefca740ad84ee7944c4d360a3d027e