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Autor:
Ryan T Davison, Xintong Hou, Vy M. Dong, Patrick D Parker, Sara A Augustine, Crystal P. Chung
Publikováno v:
Angew Chem Int Ed Engl
By using Rh-H catalysis, we couple α-nitroesters and alkynes to prepare α-amino acid precursors. This atom-economical strategy generates two contiguous stereocenters, with high enantio- and diastereocontrol. In this transformation, the alkyne under